Motivational Non-directive Resonance Breathing as a Treatment for Chronic Widespread Pain

Paccione, Charles Ethan; Jacobsen, Henrik Børsting

doi:10.3389/fpsyg.2019.01207

Cited by 17 publications

(22 citation statements)

References 219 publications

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“…MNRB™ is a meditation-based deep breathing intervention developed by the lead author (CEP) [39] which is based on emergent ndings in integrative neuroscience and autonomic self-regulation in cardiopulmonology.…”

Section: Description Of Intervention Arms 1 Motivational Nondirectivmentioning

confidence: 99%

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Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Paccione¹,

Diep

Stubhaug

et al. 2020

Preprint

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BackgroundChronic widespread pain (CWP), including fibromyalgia (FM), affects one in every ten adults and is one of the leading causes of sick leave and emotional distress. Due to an unclear etiology and a complex pathophysiology, FM is a condition with few, if any, effective and safe treatments. However, current research within the field of vagal nerve innervation suggests psychophysiological and electrical means by which FM may be treated. This study will investigate the efficacy of two different non-invasive vagal nerve stimulation techniques for the treatment of FM.MethodsThe study will use a randomized, single blind, sham-controlled design to investigate the treatment efficacy of motivational nondirective resonance breathing (MNRBTM) and transcutaneous vagus nerve stimulation (Nemos® tVNS) on patients diagnosed with FM. Consenting FM patients (N=112) who are referred to the Department of Pain Management and Research at Oslo University Hospital, in Oslo, Norway, will be randomized into one of four independent groups. Half of these participants (N=56) will be randomized to either an experimental tVNS group or a sham tVNS group. The other half (N=56) will be randomized to either an experimental MNRB group or a sham MNRB group. Both active and sham treatment interventions will be delivered twice per day at home, 15 min/morning and 15 min/evening, for a total duration of 2 weeks (14 days). Participants are invited to the clinic twice, once for pre- and once for post-intervention data collection. The primary outcome is changes in photoplethysmography measured heart rate variability. Secondary outcomes include self-reported pain intensity on a numeric rating scale, changes in pain detection threshold, pain tolerance threshold, and pain-pressure limit determined by computerized pressure cuff algometry, blood pressure, and health related quality of life.DiscussionThe described randomized controlled trial aims to compare the efficacy of two vagal nerve innervation interventions, MNRB and tVNS, on heart rate variability and pain intensity in patients suffering from FM. This project tests a new and potentially effective means of treating a major public and global health concern where prevalence is high, disability is severe, and treatment options are limited.Trial registrationClinicalTrials.gov Identifier: NCT03180554; Date of Registration: 08/06/2017

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Section: Description Of Intervention Arms 1 Motivational Nondirectivmentioning

confidence: 99%

“…Attention is neither directed toward staying with the respiration sound guides nor directed toward observing the spontaneous ow of thoughts and sensations [44]. Sensations, such as pain, during MNRB™ are accepted without actively directing attention toward them or away from them [39].…”

Section: Description Of Intervention Arms 1 Motivational Nondirectivmentioning

confidence: 99%

Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Paccione¹,

Diep

Stubhaug

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Opioids fail to alleviate pain intensity and function [ 4 ] and cause a myriad of adverse side-effects [ 5 ] while complementary and alternative treatments have only weak to moderate effect sizes for treating CWP [ 6 ]. However, vagal nerve innervation may provide us with innovative and successful opportunities to target the complex psychophysiological framework of FM [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Preliminary intervention trials on humans [ 10 , 11 ] have shown that vagus nerve stimulation (VNS) can modulate multiple pathophysiological mechanisms inherent in various CWP conditions such as FM: VNS has shown to strongly reduce peripheral inflammatory cytokines [ 12 ] decrease sympathetic tone [ 13 ], decrease oxidative stress [ 14 ], and reverse pain-related brain activity patterns [ 7 , 15 ]. To date, VNS has been traditionally administered through invasive procedures, known as invasive VNS (iVNS), which typically involves the surgical implantation of electrodes around the vagus nerve [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, the positive analgesic effects deep breathing may have on some acute pain conditions has failed to be established for CP conditions such as CWP [ 8 ]. In particular, research on mindfulness-based meditation interventions show contradictory findings [ 20 ], differences in conceptualization and practice [ 21 ], positive report biases [ 22 ], and only small to moderate effect sizes for treating pain in clinical populations [ 7 , 23 , 24 ]. Experimental evidence elucidating the underlying psychophysiological mechanisms of how deep breathing may be used to treat CWP is lacking and often inconsistent [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Paccione

Diep²,

Stubhaug

et al. 2020

Trials

Self Cite

View full text Add to dashboard Cite

Background Chronic widespread pain (CWP), including fibromyalgia (FM), affects one in every ten adults and is one of the leading causes of sick leave and emotional distress. Due to an unclear etiology and a complex pathophysiology, FM is a condition with few, if any, effective and safe treatments. However, current research within the field of vagal nerve innervation suggests psychophysiological and electrical means by which FM may be treated. This study will investigate the efficacy of two different noninvasive vagal nerve stimulation techniques for the treatment of FM. Methods The study will use a randomized, single-blind, sham-controlled design to investigate the treatment efficacy of motivational nondirective resonance breathing (MNRB™) and transcutaneous vagus nerve stimulation (Nemos® tVNS) on patients diagnosed with FM. Consenting FM patients (N = 112) who are referred to the Department of Pain Management and Research at Oslo University Hospital, in Oslo, Norway, will be randomized into one of four independent groups. Half of these participants (N = 56) will be randomized to either an experimental tVNS group or a sham tVNS group. The other half (N = 56) will be randomized to either an experimental MNRB group or a sham MNRB group. Both active and sham treatment interventions will be delivered twice per day at home, 15 min/morning and 15 min/evening, for a total duration of 2 weeks (14 days). Participants are invited to the clinic twice, once for pre- and once for post-intervention data collection. The primary outcome is changes in photoplethysmography-measured heart rate variability. Secondary outcomes include self-reported pain intensity on a numeric rating scale, changes in pain detection threshold, pain tolerance threshold, and pressure pain limit determined by computerized pressure cuff algometry, blood pressure, and health-related quality of life. Discussion The described randomized controlled trial aims to compare the efficacy of two vagal nerve innervation interventions, MNRB and tVNS, on heart rate variability and pain intensity in patients suffering from FM. This project tests a new and potentially effective means of treating a major public and global health concern where prevalence is high, disability is severe, and treatment options are limited. Trial registration ClinicalTrials.govNCT03180554. Registered on August 06, 2017.

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Treatment Interventions I: Working with the Body

Kozlowska

Scher

Helgeland

2020

Functional Somatic Symptoms in Children and Adolescents

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From the perspective of the stress-system model, the treatment of functional somatic symptoms involves a system-level approach. The factors that contribute to stress-system dysregulation and the emergence of functional somatic symptoms operate, both proximally and over longer periods, on different system levels: body, mind, attachment and family relationships, academic expectations, and interactions and relationships at school with other children, teachers, and even health professionals. The treatment program will therefore require a multi-levelled, systems approach that is designed to meet the specific, but diverse, needs of each particular child and the family. In this way, the mental health clinician or, more usually, the clinicians that make up the multidisciplinary team work with the child to implement interventions on the body and mind system levels; with the family to 14 Treatment Interventions I: Working with the Body

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Motivational Non-directive Resonance Breathing as a Treatment for Chronic Widespread Pain

Cited by 17 publications

References 219 publications

Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Motivational nondirective resonance breathing versus transcutaneous vagus nerve stimulation in the treatment of fibromyalgia: study protocol for a randomized controlled trial

Treatment Interventions I: Working with the Body

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