The purposes of the present study is twofold; firstly, it attempts to translate and adapt the "Motivation and Self-Regulation Scale" developed by Velayutham, Aldridge, and Fraser (2011) into Turkish. Motivation and Self-Regulation Scale is 32-item and four-dimensioned (learning goals, task value self-efficacy, and selfregulation) scale. Secondly, the relationship between students' motivation and selfregulatory skills in science learning was investigated. The study was a survey with a cross-sectional design. For validation and reliability process, 1128 eighth-grade students from 14 different schools participated in the study. In addition, for the motivation and self-regulatory skills relationship investigation the responses provided by the translated version of the scale of 1484 students from 14 different schools were used. Data were analyzed via exploratory and confirmatory factor analysis, Mann Whitney U test and multiple regression analysis. As a result, the 32-item original scale was translated and adapted into Turkish and through the validation and reliability process the translated version of the scale was decreased to 25 items considering cultural adaptation. The findings of this study revealed that both the dimensions of motivation, learning goals, task value and self-efficacy, and self-regulation skills, had a significant correlation with the student's success. Moreover, learning goals, task value, and self-efficacy, were found to be significantly correlated to the level of self-regulatory skills.