Motivating K-12 students to study pharmaceutical engineering using guided hands-on visits

Mateo-Ortiz, Daniel; Mota-Aguilar, David A.; Florian-Algarin, Miguel; Avilés-Barreto, Sonia L.; Méndez, Rafael; Velázquez, Carlos; Cardona-Martı́nez, Nelson

doi:10.1016/j.ece.2012.09.002

Cited by 4 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent regulations by US Food and Drug Administration (US FDA) replace the traditional empiricism with advanced Process Analytical Technology (PAT) and quality by design (QbD) (Mateo-Ortíz et al 2012). The acceptance of QbD in pharmaceutical circles is largely endorsed to the latest initiatives provided by the International Conference on Standardization (ICH), Food and Drug Administration (FDA) and European Medical Agency (EMEA) through their respective federal guidance.…”

Section: Introductionmentioning

confidence: 99%

Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design

George

Singh

Verma

2015

Journal of Pharmaceutical Investigation

View full text Add to dashboard Cite

The present study aimed to develop an ideal nanostructured delivery (propylene glycol monocaprylatepolycaprolactone core-shell nanostructures) for a poorly soluble drug by quality-by-design (QbD) approach. Carvedilol (CVD) loaded polymeric nanocapsules were formulated by 3 2 factorial designs and established the functional relationships between the operating independent variables. An increase in polycaprolactone (PCL) content led to a rise in mean particle size, while the effect of Lutrol F127 was found statistically insignificant. Furthermore, it was observed that as the level of Lutrol F127 increases zeta potential decreases. However different levels of PCL did not significantly affected the zeta potential. The in vitro release of carvedilol from nanocapsule is contributed by the coupling of diffusion and erosion mechanism. Scanning electron microscopy, transmission electron microscopy (TEM) and atomic force microscopy (AFM) images showed the spherical nature of prepared optimized formulations OF1-OF3. TEM images illustrated spherical nanocapsules with a clearly distinctive oil core and PCL coating. The thickness of the core varied from 14.78 to 54.21 nm. The smooth surface of nanocapsules observed under AFM studies indicated no surface crystallization of CVD or other excipients used in preparing optimized formulations. The root mean square roughness and the average volume of optimized nanocapsules (OF1-OF3) ranged between 14.42-23.26 nm and 24.41-49.91 lm 3 , respectively. This study revealed the effectiveness of QbD for the preparation of optimized nanocapsules of CVD having desired attributes in the shortest possible time.

show abstract

Section: Introductionmentioning

confidence: 99%

Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design

George

Singh

Verma

2015

Journal of Pharmaceutical Investigation

View full text Add to dashboard Cite

show abstract

“…10,12,[22][23][24][25][26][27][28][29] In an effort to help increase K-12 students' exposure to engineering, many universities and professional societies have initiated a variety of outreach programs and summer camps. [30][31][32][33][34][35][36][37][38][39][40][41][42] Although many of these efforts are very effective at exposing K-12 students to engineering, they are not always equally effective for all populations at inspiring these students to consider engineering as a possible career path. 38 Outreach activities that promote negative stereotypes regarding engineers or the profession can be counterproductive to encouraging females to pursue engineering.…”

Section: -16mentioning

confidence: 99%

Assessing the Efficacy of K-12 Engineering Outreach "Pick Up and Go" Kits

Pinnell¹,

Hart²,

Bistrek³

et al.

2016 ASEE Annual Conference &Amp; Exposition Proceedings

View full text Add to dashboard Cite

With the growing emphasis of Science, Technology, Engineering and Mathematics (STEM) education at the K-12 level, many schools are reaching out to colleges and universities to have engineering faculty and students visit their classrooms. However, engineering faculty and students may be reluctant to engage in this outreach because they do not have the time or resources to develop an appropriate activity. To address this issue "pick up and go" engineering activity outreach modules were developed, piloted and assessed in K-12 classrooms and afterschool programs. These activity modules were developed to incorporate research based best practices and principles that have been found to be successful in attracting girls to engineering and all activities were mapped to the Ohio Academic Content Standards. The modules focused on engineering design and innovation, such that the activities encouraged team work, creativity and problem solving. Scenarios were provided as part of the activities to demonstrate the social relevance of engineering. The kits contained all materials needed to facilitate the activities, a memory stick with an introductory power point presentation, complete instructions aimed at both the college student facilitator and a separate document for the K-12 teacher, evaluation forms and pre-and post-test forms. Through this project, nine kits were fully developed, piloted and assessed. These kits were facilitated to over 1200 K-12 students, primarily in grades 3 through 6. Facilitator feedback showed that the kits were easy to use and the instructions were both complete and easy to follow. The teachers felt that their students learned a great deal about engineering from these activities. The mean gain in pre-to post-test scores was found to be significantly greater than zero for all students, however the main gain for the female students was found to be higher than that of the male students. These results show that the outreach activities were effective at increasing the K-12 students' attitudes, interest and awareness towards STEM, but they were more effective for the females.

show abstract

“…The role of hands-on experiments in the K-12 education has also been discussed 5 . In this research, the results of an educational initiative have been presented where graduate and undergraduate students guide K-12 students through a series of hands-on modules in a pharmaceutical operations laboratory.…”

Section: Introductionmentioning

confidence: 99%

Effective use of an Undergraduate Research Fellowship for Design and Manufacture of Tools to Assist in Teaching Strength of Materials

Finley¹,

Ghorashi

2013 ASEE Annual Conference &Amp; Exposition Proceedings

View full text Add to dashboard Cite

Jacob Finley came to the University of Southern Maine in spring 2010. He is majoring in Mechanical Engineering. Finley became fascinated with mechanical properties of materials after taking a class with Dr. Ghorashi and observing the applications of the subject. He then teamed up with this professor and developed a way of demonstrating complex concepts in solid mechanics with easy to understand hands-on test set ups. Finley has always thoroughly enjoyed working on hands-on projects built from conception to execution. The main issue he addresses in his current research is developing ways to demonstrate mechanical behavior of structures and to measure the mechanical properties of materials to students in a way that is easy to understand.

show abstract

Motivating K-12 students to study pharmaceutical engineering using guided hands-on visits

Cited by 4 publications

References 21 publications

Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design

Morphological and in vitro investigation of core–shell nanostructures of carvedilol using quality by design

Assessing the Efficacy of K-12 Engineering Outreach "Pick Up and Go" Kits

Effective use of an Undergraduate Research Fellowship for Design and Manufacture of Tools to Assist in Teaching Strength of Materials

Contact Info

Product

Resources

About