Motions of the human cardiac cell electrophysiology model

Abstract

One of the many processes in the human body on which our lives depend is the proper propagation of the electrical signal in the heart tissue. This propagation is dependent on the work of each heart cell, and even small variations in the synchronous work of these cells can lead to life-threatening conditions. A proper understanding of cardiac electrophysiology is therefore essential to understanding heart function and treating heart disease. In this work, cardiac electrophysiology is investigated using a mathematical model of a human ventricular cell (Bueno-Orovio-Cherry-Fenton model). This model is paced by regular stimulation impulses, and its responses to this stimulation are analyzed in terms of their dynamic properties, and the dependence of its dynamic parameters for the frequency and amplitude of stimulation. For this analysis, classical and modern tools from the field of dynamic systems theory (e.g. entropy measures, Fourier spectra, the 0-1 test for chaos) are used.