Motional heterogeneity and phase separation of functionalized polyester polyurethanes

Čulin, Jelena; Andreis, Mladen; Šmit, Ivan; Veksli, Zorica; Anžlovar, Alojz; Žigon, Majda

doi:10.1016/j.eurpolymj.2004.02.029

Cited by 27 publications

(29 citation statements)

References 25 publications

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“…Weight average molecular weights and polydispersity indexes are shown inTable 2. The synthesis protocol followed in this work leads to high molecular weights, even higher than reported in bibliography for similar systems [20]. As IPDI/(PCL + DMPA) molar ratio increases the M W value decreases.…”

Section: Properties Of Polyurethane Filmsmentioning

confidence: 71%

Relationship between reagents molar ratio and dispersion stability and film properties of waterborne polyurethanes

Santamaria‐Echart

Arbelaiz

Saralegi

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Properties Of Polyurethane Filmsmentioning

confidence: 71%

Relationship between reagents molar ratio and dispersion stability and film properties of waterborne polyurethanes

Santamaria‐Echart

Arbelaiz

Saralegi

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…However, this did not impede the production of high Mw polyurethane. The incorporation of ( 3 ) at 0.12 mmol.g −1 of PU‐NF 2 disrupted the noncovalent interactions in the macromolecule structure, compared to PU‐control as shown by the thermal and infrared analysis 29. It is not surprising to observe that the addition of low amounts of isoprenoid can influence phase segregation in polyurethane.…”

Section: Discussionmentioning

confidence: 95%

Farsenol‐modified biodegradable polyurethanes for cartilage tissue engineering

Eglin

Grad

Gogolewski

et al. 2009

J Biomedical Materials Res

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A bifunctionalized 3,7,11-trimethyl-2,6,10-dodecatrien-1-diaminobutane amide (isoprenoid) was obtained from 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol (farnesol) in a three-step synthesis. The bifunctionalized isoprenoid was characterized using infrared spectroscopy and (1)H and (13)C nuclear magnetic resonance spectroscopy and was covalently incorporated (0.12 mmol x g(-1)) into the biodegradable aliphatic polyurethane formed on the polycondensation reaction of poly(epsilon-caprolactone) diol, 1,4,3,6-dianhydro-D-sorbitol and 1,6-hexamethylene diisocyanate. Although the covalent incorporation of the isoprenoid molecule into the polyurethane chain modified the surface chemistry of the polymer, it did not affect the viability of attached chondrocytes. Porous 3D scaffolds were produced from the modified and unmodified biodegradable segmented polyurethanes by a salt leaching-phase-inverse technique. The scaffolds were seeded with bovine chondrocytes encapsulated in fibrin gel and cultured in vitro for 14 days. The incorporation of bifunctional isoprenoid into the polyurethane affected the morphology of the scaffolds produced, when compared with the morphology of the scaffolds produced using the same technique from the unmodified polyurethane. As a consequence, there was more uniform cell seeding and more homogeneous distribution of the synthesized extracellular matrix throughout the scaffold resulting in a reduced cell/tissue layer at the edges of the constructs. However, glycosaminoglycan (GAG), DNA content, and chondrocytes phenotype in the scaffolds produced from these two polyurethane formulations did not vary significantly. The findings suggest that the change of surface characteristics and the more open pore structure of the scaffolds produced from the isoprenoid-modified polyurethane are beneficial for the seeding efficiency and the homogeneity of the tissue engineered constructs.

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“…This suggests that PU hard segments are partitioned in two motionally different environments. It was concluded that motional heterogeneity increases with an increase of functional groups up to 0.35 mmol/g and above this concentration slow component decreases indicating higher degree of phase mixing and stronger effect of soft segments [57].…”

Section: Copolymersmentioning

confidence: 99%