Motion Perimetry Identifies Nerve Fiber Bundlelike Defects in Ocular Hypertension

Retinal ganglion cell death in experimental glaucoma

“…Tests that focus on magnocellular function can detect early damage in glaucoma and ocular hypertension36 but do not test whether that damage is selective for the magnocellular pathway. Psychophysical studies in which the two pathways were distinguished using flickering or stationary sinusoidal gratings, have suggested selective damage to the magnocellular pathway 37.…”

Effects of retinal image degradation on pre‐attentive visual search (PAVS) efficiency for flicker, movement and orientation stimuli

“…Many attempts have been made to devise new psychophysical tests to evaluate the functional integrity of the optic nerve, and detect glaucomatous damage at the earliest possible stage of the neuropathy (e.g. Fitzke et al, 1987;Wall and Ketoff, 1995;Johnson and Samuels, 1997;Wall et al, 1997). Conventional tonometric, ophthalmoscopic and perimetric techniques are all flawed to the extent that currently glaucoma cannot be diagnosed until a substantial proportion of optic nerve fibres have been significantly damaged and even destroyed (Quigley et al, 1988).…”

Detecting Functional Changes in the Patient’s Vision: Visual Field Analysis

“…[104][105][106][107][108][109][110][111][112][113][114][115][116][117] There are two basic methods of conducting motion detection thresholds. One method evaluates the minimum spatial displacement of a target on a uniform background [104][105][106] and the other uses a variable size random cluster of small dots that either move in the same direction while other dots are stationary (size thresholds) [107][108][109] or a proportion of dots move coherently in the same direction while other dots are moving randomly (coherence thresholds). [110][111][112][113][114][115][116] Each of these procedures have been reported to be effective in detecting early glaucomatous visual field loss.…”