Motion Correction in Dual Gated Cardiac PET Using Mass-Preserving Image Registration

Gigengack, Fabian; Ruthotto, Lars; Burger, Martin; Wolters, Carsten H.; Jiang, Xiaoyi; Schäfers, Klaus P.

doi:10.1109/tmi.2011.2175402

Cited by 132 publications

(145 citation statements)

References 48 publications

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“…Several methods have been proposed to obtain motion information directly from 18 F-FDG PET scans (7,8,(11)(12)(13). Nevertheless, the accuracy of the estimated motion depends, especially for nonrigid cardiac motion, on sufficient PET uptake in the ventricle.…”

Section: Discussionmentioning

confidence: 99%

“…Motion correction is achieved either by combining transformed images after image reconstruction (6), as a preprocessing step before image reconstruction (7,8) or during an iterative reconstruction scheme (i.e., motion-corrected image reconstruction [MCIR]) (9). Several techniques derive motion information directly from PET data (7,8,(10)(11)(12). Nevertheless, this requires sufficient tracer uptake in the region of interest for all subdivided motion states.…”

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confidence: 99%

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Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

et al. 2017

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Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study was to investigate a new cardiac PET/MR approach providing respiratory and cardiac motion-compensated MR and PET images in less than 5 min. Methods: Free-breathing 3-dimensional MR data were acquired and retrospectively binned into multiple respiratory and cardiac motion states. Three-dimensional cardiac and respiratory motion fields were obtained with a nonrigid registration algorithm and used in motion-compensated MR and PET reconstructions to improve image quality. The improvement in image quality and diagnostic accuracy of the technique was assessed in simultaneous 18 F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a human subject. Results: MR motion fields were successfully used to compensate for in vivo cardiac motion, leading to improvements in full width at half maximum of the canine myocardium of 13% 6 5%, similar to cardiac gating but with a 90% 6 57% higher contrast-to-noise ratio between myocardium and blood. Motion correction led to an improvement in MR image quality in all subjects, with an increase in sharpness of the canine coronary arteries of 85% 6 72%. A functional assessment showed good agreement with standard MR cine scans with a difference in ejection fraction of 22% 6 3%. MR-based respiratory and cardiac motion information was used to improve the PET image quality of a human in vivo scan. Conclusion: The MR technique presented here provides both diagnostic and motion information that can be used to improve MR and PET image quality. Reliable respiratory and cardiac motion correction could make cardiac PET results more reproducible.

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Section: Discussionmentioning

confidence: 99%

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Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

et al. 2017

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“…Dual gating (cardiac/respiratory) (15,16) and dual correction have been reported by several groups (5,6,17,18). However, all of these methods depend on uptake in anatomic organs (in the case of cardiac imaging, the myocardium) and therefore are not applicable to coronary PET.…”

Section: Discussionmentioning

confidence: 99%

“…The implication is a greater risk of misclassification when this technique is applied to real-world, unselected populations. Unfortunately, recent general-purpose motion correction methods proposed for PET (5,6) are not applicable because of lack of clear anatomic landmarks in the heart region on the 18 F-NaF scan. To partially address the problem of motion, only a single cardiac phase (representing about 25% of the PET data) was used in the initial study (2), at the expense of a significant increase in noise.…”

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Motion Correction of ¹⁸F-NaF PET for Imaging Coronary Atherosclerotic Plaques

et al. 2015

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Ruptured coronary atherosclerotic plaques commonly cause acute myocardial infarction. It has recently been shown that active microcalcification in the coronary arteries, one of the features that characterizes vulnerable plaques at risk of rupture, can be imaged using 18 F-NaF PET. We aimed to determine whether a motion correction technique applied to gated 18 F-NaF PET images could enhance image quality and improve uptake estimates. Methods: Seventeen patients with myocardial infarction (n 5 7) or stable angina (n 5 10) underwent 18 F-NaF PET and prospective coronary CT angiography. PET data were reconstructed in 4 different ways: the first was 1 gated bin (end-diastolic phase with 25% of the counts), the second was 4 gated bins (consecutive 25% segments), the third was 10 gated bins (consecutive 10% segments), and the fourth was ungated. Subsequently, with data from either 4 or 10 bins, gated PET images were registered using a local, nonlinear motion correction method guided by the extracted coronary arteries from CT angiography. Global noise levels and target-to-background ratios (TBR) defined on manually delineated coronary plaque lesions were compared to assess image quality and uptake estimates. Results: Compared with the reference standard of using only 1 bin of PET data, motion correction using 10 bins of PET data reduced image noise by 46% (P , 0.0001). TBR in positive lesions for 10-bin motion-corrected data was 11% higher than for 1-bin data (1.98 [interquartile range, 1.70-2.37] vs. 1.78 [1.58-2.16], P 5 0.0027) and 33% higher than for ungated data (1.98 [1.70-2.37] vs. 1.49 [1.39-1.88], P , 0.0001). Conclusion: Motion correction of gated 18 F-NaF PET/coronary CT angiography is feasible, reduces image noise, and increases TBR. This improvement may allow more reliable identification of vulnerable coronary artery plaques using 18 F-NaF PET.

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“…This is the first attempt to optimize the reconstruction of myocardial perfusion Flurpiridaz F 18 images with respect to cardiac and respiratory motion. Dual-gating (cardiac/respiratory) (23)(24)(25)(26) and preliminary methods for dual motion correction for phantom data and 18 F-FDG have been reported (27)(28)(29) but have not yet been applied to myocardial perfusion imaging and did not use the advanced reconstruction with resolution recovery. Clinical implementation of the dual-gating technique will likely lead to the improved clinical utility of the Flurpiridaz F 18 images but nevertheless adds additional technical complexity.…”

Section: Tablementioning

confidence: 99%

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

et al. 2015

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A novel PET radiotracer, Flurpiridaz F 18, has undergone phase II clinical trial evaluation as a high-resolution PET cardiac perfusion imaging agent. In a subgroup of patients imaged with this agent, we assessed the feasibility and benefit of simultaneous correction of respiratory and cardiac motion. Methods: In 16 patients, PET imaging was performed on a 4-ring scanner in dual cardiac and respiratory gating mode. Four sets of data were reconstructed with high-definition reconstruction (HD•PET): ungated and 8-bin electrocardiographygated images using 5-min acquisition, optimal respiratory gating (ORG)-as developed for oncologic imaging-using a narrow range of breathing amplitude around end-expiration level with 35% of the counts in a 7-min acquisition, and 4-bin respiration-gated and 8-bin electrocardiography-gated images (32 bins in total) using the 7-min acquisition (dual-gating, using all data). Motion-frozen (MF) registration algorithms were applied to electrocardiography-gated and dual-gated data, creating cardiac-MF and dual-MF images. We computed wall thickness, wall/cavity contrast, and contrast-to-noise ratio for standard, ORG, cardiac-MF, and dual-MF images to assess image quality. Results: The wall/cavity contrast was similar for ungated (9.3 ± 2.9) and ORG (9.5 ± 3.2) images and improved for cardiac-MF (10.8 ± 3.6) and dual-MF images (14.8 ± 8.0) (P , 0.05). The contrast-to-noise ratio was 22.2 ± 9.1 with ungated, 24.7 ± 12.2 with ORG, 35.5 ± 12.8 with cardiac-MF, and 42.1 ± 13.2 with dual-MF images (all P , 0.05). The wall thickness was significantly decreased (P , 0.05) with dual-MF (11.6 ± 1.9 mm) compared with ungated (13.9 ± 2.8 mm), ORG (13.1 ± 2.9 mm), and cardiac-MF images (12.1 ± 2.7 mm). Conclusion: Dual (respiratory/cardiac)-gated perfusion imaging with Flurpiridaz F 18 is feasible and improves image resolution, contrast, and contrastto-noise ratio when MF registration methods are applied. (2) and better image quality, interpretative certainty, and diagnostic performance than SPECT in a phase 2 clinical trial (3). In particular, imaging with this 18 F-based radiotracer generated higher-resolution cardiac images (4).However, the high image resolution associated with an 18 F-based tracer can be degraded by cardiac and respiratory motion during PET acquisition, leading to image blurring. If such motion is not corrected, the full-potential imaging resolution of Flurpiridaz F 18 may not be realized. We have previously developed a motion-frozen (MF) technique for myocardial perfusion imaging, which recovers resolution lost due to cardiac motion, improving contrast and quantitative diagnostic accuracy (5,6). This technique was also successfully used for automatic coregistration of SPECT with CT angiography (CTA) (7,8) and for contrast improvement in cardiac PET (9).The aim of this study was to investigate the feasibility of myocardial perfusion imaging by Flurpiridaz F 18 PET with correction of both cardiac and respiratory motion. We hypothesized that the myocardial perfusion image quality for F...

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Motion Correction in Dual Gated Cardiac PET Using Mass-Preserving Image Registration

Cited by 132 publications

References 48 publications

Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

Motion Correction of ¹⁸F-NaF PET for Imaging Coronary Atherosclerotic Plaques

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

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Motion Correction in Dual Gated Cardiac PET Using Mass-Preserving Image Registration

Cited by 132 publications

References 48 publications

Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

Cardiac and Respiratory Motion Correction for Simultaneous Cardiac PET/MR

Motion Correction of 18F-NaF PET for Imaging Coronary Atherosclerotic Plaques

Dual-Gated Motion-Frozen Cardiac PET with Flurpiridaz F 18

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Motion Correction of ¹⁸F-NaF PET for Imaging Coronary Atherosclerotic Plaques