Motion-corrected echo decorrelation imaging of in vivo focused and bulk ultrasound ablation in a rabbit liver cancer model

Fosnight, Tyler R.; Hooi, Fong Ming; Keil, Ryan; Subramanian, Shankar C.; Barthé, Peter G.; Wang, Yan; Ren, Xiaoping; Ahmad, Syed A.; Rao, Marepalli B.; Mast, T. Douglas

doi:10.1109/ultsym.2014.0538

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…However, an appropriate choice of echo decorrelation threshold can provide high prediction specificity, which is appropriate for ablation control using echo decorrelation imaging as discussed below. Prediction performance by echo decorrelation was generally better than prediction by IBS, with significantly higher AUC values for focused exposures and all exposures combined in liver tissue, consistent with previous observations (Fosnight et al 2014; Mast et al 2008; Subramanian et al 2014). AUC values for ablation prediction by IBS were not significantly higher than those for echo decorrelation in any of the cases examined.…”

Section: Discussionsupporting

confidence: 89%

Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation

Fosnight

Hooi

Keil

et al. 2017

Ultrasound in Medicine & Biology

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In open surgical procedures, image-ablate ultrasound arrays performed thermal ablation and imaging on rabbit liver lobes with implanted VX2 tumor. Treatments included unfocused (bulk ultrasound ablation, N = 10) and focused (high-intensity focused ultrasound ablation, N = 13) exposure conditions. Echo decorrelation and integrated backscatter images were formed from pulse-echo data recorded during rest periods after each therapy pulse. Echo decorrelation images were corrected for artifacts using decorrelation measured prior to ablation. Ablation prediction performance was assessed using receiver operating characteristic curves. Results revealed significantly increased echo decorrelation and integrated backscatter in both ablated liver and ablated tumor relative to unablated tissue, with larger differences observed in liver than in tumor. For receiver operating characteristic curves computed from all ablation exposures, both echo decorrelation and integrated backscatter predicted liver and tumor ablation with statistically significant success, and echo decorrelation was significantly better as a predictor of liver ablation. These results indicate echo decorrelation imaging is a successful predictor of local thermal ablation in both normal liver and tumor tissue, with potential for real-time therapy monitoring.

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Section: Discussionsupporting

confidence: 89%

Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation

Fosnight

Hooi

Keil

et al. 2017

Ultrasound in Medicine & Biology

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“…(1) is normalized by the inter-frame time τ to define the echo decorrelation map per millisecond (Fosnight et al, 2017) and by the average of β 2 ( y , z , t ) and β2¯ to reduce decorrelation artifacts in hypoechoic and hyperechoic regions respectively (Mast et al, 2008). More detailed derivation and analysis of echo decorrelation imaging is given elsewhere (Mast et al, 2008; Subramanian et al, 2014; Fosnight et al, 2014, 2017; Hooi et al, 2015).…”

Section: Methodsmentioning

confidence: 99%

“…For comparison, series of uncontrolled HIFU ablation trials (5.0 MHz, 24% duty cycle) were also performed. The maximum number of uncontrolled therapy cycles was selected to be 9, corresponding to the number previously found sufficient to ensure in vivo ablation of both rabbit liver and VX2 tumor (Fosnight et al, 2017, 2014). A total of 10 uncontrolled trials were performed using this maximum duration (total time 26.1 s for 9 cycles).…”

Section: Methodsmentioning

confidence: 99%

“…Echo decorrelation imaging (Mast et al, 2008; Matsuzawa et al, 2012; Subramanian et al, 2014; Sasaki et al, 2014; Fosnight et al, 2017) potentially overcomes these errors by utilizing heat-induced, millisecond-scale echo variations to spatially map thermal lesioning during HIFU thermal ablation. Echo decorrelation imaging has been successfully validated for prediction of in vivo HIFU thermal lesioning in normal and VX2 rabbit tumor liver tissue (Fosnight et al, 2017, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Abbass

Killin

Mahalingam

et al. 2018

Ultrasound in Medicine & Biology

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The ability to control high-intensity focused ultrasound (HIFU) thermal ablation using echo decorrelation imaging feedback was evaluated in ex vivo bovine liver. Sonications were automatically ceased when the minimum cumulative echo decorrelation within the region of interest exceeded an ablation control threshold, determined from preliminary experiments as -2.7 (log-scaled decorrelation per millisecond), corresponding to 90% specificity for local ablation prediction. Controlled HIFU thermal ablation experiments were compared with uncontrolled experiments employing two, five or nine sonication cycles. Means and standard errors of the lesion width, area and depth, as well as receiver operating characteristic curves testing ablation prediction performance, were computed for each group. Controlled trials exhibited significantly smaller average lesion area, width and treatment time than five-cycle or nine-cycle uncontrolled trials and also had significantly greater prediction capability than two-cycle uncontrolled trials. These results suggest echo decorrelation imaging is an effective approach to real-time HIFU ablation control.

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Investigation of Post-mortem Tissue Effects Using Long-time Decorrelation Ultrasound

Csány¹,

Gyöngy²

2015

Physics Procedia

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Motion-corrected echo decorrelation imaging of in vivo focused and bulk ultrasound ablation in a rabbit liver cancer model

Cited by 3 publications

References 16 publications

Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation

Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation

Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo Decorrelation Imaging in ex Vivo Bovine Liver

Investigation of Post-mortem Tissue Effects Using Long-time Decorrelation Ultrasound

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