Motility states in bidirectional cargo transport

Klein, Sarah; Appert-Rolland, Cécile; Santen, Ludger

doi:10.1209/0295-5075/111/68005

Cited by 14 publications

(10 citation statements)

References 18 publications

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“…The model assumes that motors of each type equally share the load per node. When the motors are crowded this is unlikely to be the case [39], but in our system even when N K = N D = 32 the motors should not be crowded on a filament due to the node spacing. For computational convenience, in the numerical algorithm we assume binding events on each node are independent of binding events on other nodes.…”

Section: Discussionmentioning

confidence: 77%

Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport

Dallon

Leduc

Etienne-Manneville

et al. 2019

Journal of Theoretical Biology

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Intermediate filaments are a key component of the cytoskeleton. Their transport along microtubules plays an essential role in the control of the shape and structural organization of cells. To identify the key parameters responsible for the control of intermediate filament transport, we generated a model of elastic filament transport by microtubule-associated dynein and kinesin. The model is also applicable to the transport of any elastically-coupled cargoes. We investigate the effect of filament properties such as number of motor binding sites, length, and elasticity on motion of filaments. Additionally, we consider the effect of motor properties, i.e. off rates, on filament transport. When one motor has a catch bond off rate it dictates the motion, whereas when motors have the same type of off rate filaments can alternate between retrograde and anterograde motions. The elasticity of filaments optimizes the filament transport and the coordination of motors along the length of the filament.

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Section: Discussionmentioning

confidence: 77%

Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport

Dallon

Leduc

Etienne-Manneville

et al. 2019

Journal of Theoretical Biology

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“…Indeed, when motor position is explicitely considered, it turns out that motors which are oppositely directed to the dominant motor species are not automatically disrupted from the MT. Thus the efficiency of the tug-of-war mechanism is drastically reduced, in the sense that the symmetric bimodal distributions observed in the mean field model do not exist anymore [195]. This is not necessarily a drawback, as these symmetric bimodal distributions have never been clearly evidenced experimentally.…”

Section: Tug-of-warmentioning

confidence: 95%

Intracellular transport driven by cytoskeletal motors: General mechanisms and defects

2015

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Cells are the elementary units of living organisms, which are able to carry out many vital functions. These functions rely on active processes on a microscopic scale. Therefore, they are strongly out-of-equilibrium systems, which are driven by continuous energy supply. The tasks that have to be performed in order to maintain the cell alive require transportation of various ingredients, some being small, others being large. Intracellular transport processes are able to induce concentration gradients and to carry objects to specific targets. These processes cannot be carried out only by diffusion, as cells may be crowded, and quite elongated on molecular scales. Therefore active transport has to be organized.The cytoskeleton, which is composed of three types of filaments (microtubules, actin and intermediate filaments), determines the shape of the cell, and plays a role in cell motion. It also serves as a road network for a special kind of vehicles, namely the cytoskeletal motors. These molecules can attach to a cytoskeletal filament, perform directed motion, possibly carrying along some cargo, and then detach.It is a central issue to understand how intracellular transport driven by molecular motors is regulated. The interest for this type of question was enhanced when it was discovered that intracellular transport breakdown is one of the signatures of some neuronal diseases like the Alzheimer.We give a survey of the current knowledge on microtubule based intracellular transport. Our review includes on the one hand an overview of biological facts, obtained from experiments, and on the other hand a presentation of some modeling attempts based on cellular automata. We present some background knowledge on the original and variants of the TASEP (Totally Asymmetric Simple Exclusion Process), before turning to more application oriented models. After addressing microtubule based transport in general, with a focus on in vitro experiments, and on cooperative effects in the transportation of large cargos by multiple motors, we concentrate on axonal transport, because of its relevance for neuronal diseases. Some important characteristics of axonal transport is that it takes place in a confined environment; Besides several types of motors are involved, that move in opposite directions. It is a challenge to understand how this bidirectional transport is organized. We review several features that could contribute to the efficiency of bidirectional transport in the axon, including in particular the role of motor-motor interactions and of the dynamics of the underlying microtubule network. Finally, we also discuss some open questions that may be relevant for future research in this field.

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“…7) [29][30][31]. The motors have a stochastic dynamics along the microtubule, and extend as a spring when they pull on the cargo that they carry.…”

Section: Tug-of-warmentioning

confidence: 99%

Proceedings of the Asia-Pacific Econophysics Conference 2016 — Big Data Analysis and Modeling toward Super Smart Society — (APEC-SSS2016)

2017

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Transport systems in physical space exhibit various phenomena which may have some counterparts in socio-or econo-systems. We review here several of them. In highway vehicular traffic, the introduction of a reaction time leads to metastability and hysteresis. Pattern formation occurs in pedestrian flows. At a microscopic scale, we can learn from molecular pedestrians that transporting an object by opposite teams can be more efficient in a crowded environment and allow for an easy control of the system. Besides, we will show that the interplay between transport and the dynamics of the underlying network can sometimes lead to positive effects in terms of efficiency of transport.

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Motility states in bidirectional cargo transport

Cited by 14 publications

References 18 publications

Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport

Stochastic modeling reveals how motor protein and filament properties affect intermediate filament transport

Intracellular transport driven by cytoskeletal motors: General mechanisms and defects

Proceedings of the Asia-Pacific Econophysics Conference 2016 — Big Data Analysis and Modeling toward Super Smart Society — (APEC-SSS2016)

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