Motility changes induced by intraluminal <scp><scp>FeSO4</scp></scp> in guinea pig jejunum

Wang, K; Senadheera, Sevvandi; Polglaze, Kate E.; Murphy, Timothy V.; Sandow, Shaun L.; Liu, L; Bornstein, Joel C.; Bertrand, Paul

doi:10.1111/nmo.12276

Cited by 1 publication

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References 62 publications

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“…In general, the mechanisms of emesis induced by cytotoxic drugs are assumed to be as follows: (1) cytotoxic drugs evoke 5-HT release from enterochromaffin cells in the intestinal mucosa; (2) the released 5-HT stimulates 5-HT receptors on the adjacent vagal afferent nerves; (3) the depolarization of the vagal afferent nerves stimulates the vomiting center in the brainstem and eventually induces a vomiting reflex; and (4) some of the released 5-HT from the enterochromaffin cells is transmitted from the chemoreceptor trigger zone to the vomiting center via the circulation. Ferrous sulfate is reported to increase the resting level of 5-HT release from segments of the guinea pig jejunum, as iron makes its way into enterochromaffin cells and either potentiates internal calcium release or acts on the calcium-dependent release machinery to increase the basal release of 5-HT [30]. Therefore, it is speculated that consecutive administration of SF not only causes hyperplasia of enterochromaffin cells but also potentiates the release of 5-HT from each enterochromaffin cell.…”

Section: Discussionmentioning

confidence: 99%

Ferric Citrate Hydrate Has Little Impact on Hyperplasia of Enterochromaffin Cells in the Rat Small Intestine Compared to Sodium Ferrous Citrate

et al. 2022

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Introduction: The most detrimental factor preventing the use of oral iron in the treatment of iron deficiency anemia is gastrointestinal side effects accompanied by nausea and vomiting. Anorexia is a known secondary effect of nausea and vomiting. The important gastrointestinal signaling molecule 5-hydroxytryptamine (5-HT) is critically involved in not only physiological function but also nausea and vomiting. The present study was designed to compare the effects of the administration of sodium ferrous citrate (SF) and ferric citrate hydrate (FC) to rats on anorexia and hyperplasia of enterochromaffin cells, which mainly synthesize and store 5-HT. Methods: Rats received either SF (3 or 30 mg/kg/day) or FC (30 mg/kg/day) orally for 4 days. Food and water intakes were measured every 24 h during the study. At 96 h after the first administration of the oral iron preparation, the duodenal and jejunal tissues were collected for analysis. Enterochromaffin cells were detected by immunohistochemical analysis. Results: Administration of 3 mg/kg SF had no effect on anorexia but led to increased hyperplasia of enterochromaffin cells in the duodenum (p < 0.1). Administration of 30 mg/kg SF significantly decreased food and water intakes and significantly increased hyperplasia of enterochromaffin cells in the duodenum and jejunum. Alternatively, administration of 30 mg/kg FC had no significant effect on food and water intakes or hyperplasia of enterochromaffin cells. Conclusion: The lower impact on the hyperplasia of enterochromaffin cells of FC compared to SF may contribute to the maintenance of rats’ physical condition.

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Section: Discussionmentioning

confidence: 99%