Motilin stimulates pepsinogen secretion in Suncus murinus

Goswami, Chayon; Tanaka, Toru; Jogahara, Takamichi; Sakai, Takafumi; Sakata, Ichiro

doi:10.1016/j.bbrc.2015.04.129

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Motilin regulates the exocrine and endocrine functions, and stimulates the release of gastric acid, pepsinogen, insulin, somatostatin and pancreatic bicarbonate/protein ( 213 – 215 , 218 , 219 ). Motilin controls the cyclic release of insulin in fasted dogs.…”

Section: Functions Of Motilin In Peripheral Organs Other Than Gi Tract and Brainmentioning

confidence: 99%

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

Kitazawa

Kaiya

2021

Front. Endocrinol.

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Motilin, produced in endocrine cells in the mucosa of the upper intestine, is an important regulator of gastrointestinal (GI) motility and mediates the phase III of interdigestive migrating motor complex (MMC) in the stomach of humans, dogs and house musk shrews through the specific motilin receptor (MLN-R). Motilin-induced MMC contributes to the maintenance of normal GI functions and transmits a hunger signal from the stomach to the brain. Motilin has been identified in various mammals, but the physiological roles of motilin in regulating GI motility in these mammals are well not understood due to inconsistencies between studies conducted on different species using a range of experimental conditions. Motilin orthologs have been identified in non-mammalian vertebrates, and the sequence of avian motilin is relatively close to that of mammals, but reptile, amphibian and fish motilins show distinctive different sequences. The MLN-R has also been identified in mammals and non-mammalian vertebrates, and can be divided into two main groups: mammal/bird/reptile/amphibian clade and fish clade. Almost 50 years have passed since discovery of motilin, here we reviewed the structure, distribution, receptor and the GI motility regulatory function of motilin in vertebrates from fish to mammals.

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Section: Functions Of Motilin In Peripheral Organs Other Than Gi Tract and Brainmentioning

confidence: 99%

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

Kitazawa

Kaiya

2021

Front. Endocrinol.

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“…Secretin therefore exerts a number of similar roles to those of CCK. Motilin is mainly released from duodenal enteroendocrine cells (Goswami, Tanaka, Jogahara, Sakai, & Sakata, 2015). While secretin tends to reduce gastric emptying, motilin tends to increase pyloric sphincter relaxation to increase flow into the duodenum, with peak motilin concentrations occurring at the same time the gastric phase of digestion is being completed (Ozaki, Onoma, Muramatsu, Sudo, Yoshida, Shiokawa, et al, 2009).…”

Section: Dietary Fibres and The Commencement Of The Intestinal Phase mentioning

confidence: 99%

The impact of dietary fibres on the physiological processes governing small intestinal digestive processes

Chater

Wilcox

Pearson

et al. 2015

Bioactive Carbohydrates and Dietary Fibre

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“…But the mechanism of action is not fully investigated. Motilin is a gut peptide, produced in the upper intestinal mucosa that induces strong contraction in the small intestine which can prolong the time of gastric emptying [55]. Tack et al (2016) have confirmed that motilininduced gastric phase III contraction may be a starvation signal during the digestive interval, which explains the cause of hunger in humans to some extent.…”

Section: The Effect Of Bacillus Velezensis On Biochemical Indices In mentioning

confidence: 97%

Effect of Bacillus velezensis to substitute in-feed antibiotics on the production, blood biochemistry and egg quality indices of laying hens

et al. 2020

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Background The excessive use of antibiotics in the livestock feed industry caused inevitable side effects of microbial resistance. Besides this residual antibiotics in animal-derived foodstuff imposed serious health problems for humans. So this study aimed to investigate the potential use of Bacillus velezensis to substitute antibiotics for poultry production. A total of 468, 49-week-old Hy-Line Brown chickens, were randomly divided into four groups the control group (regular diet), experiment group I (0.1% B. veleznesis), experiment group II (0.2% B. veleznesis), and antibiotic group (50 mg/kg flavomycin), with three replicates per group and trial period consisted on 42 days. Results The results showed that, compared with the control group, the average egg production rate and daily feed intake of experimental groups I and II increased significantly (P < 0.05), while the average egg weight was increased in experimental group II as compared to (I) (P < 0.01). The feed conversion ratio was decreased (P > 0.05) in group (II) Egg quality parameters such as yolk weight of the experimental group II was increased, but that of the antibiotic group and experiment group I was decreased, neither significant (P > 0.05). Moreover, the eggshell strength, yolk color, albumen height, and Haugh unit were significantly increased (P < 0.05). Compared with the control group, probiotic groups can increase the progesterone and motilin (P > 0.05) but decrease the secretin and cholecystokinin in the blood plasma (P > 0.05). Conclusions This study suggested that B. velezensis can substitute in-feed-antibiotics and improved most of the study parameters significantly. Which suggested that B. velezensis has potential future application value to replace the feed antibiotics.

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Motilin stimulates pepsinogen secretion in Suncus murinus

Cited by 6 publications

References 28 publications

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility

The impact of dietary fibres on the physiological processes governing small intestinal digestive processes

Effect of Bacillus velezensis to substitute in-feed antibiotics on the production, blood biochemistry and egg quality indices of laying hens

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