Motilin and a synthetic enkephalin induce colonic motor complexes (CMC) in the conscious dog

Bickel, M.; Belz, Ulrich

doi:10.1016/0196-9781(88)90155-6

Cited by 19 publications

(8 citation statements)

References 17 publications

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“…Intravenous injection of 3pg/kg of motilin was reported to induce colonic motor complexes (Bickel and Belz 1988). This is not in conflict with our present results, because intravenous volus injection of 3 pg/kg of motilin must elicit a plasma motilin concentration to above the physiological peak value.…”

Section: Disucussioncontrasting

confidence: 57%

“…There have been few reports describing the effect of motilin on colonic motility; in an in vitro study, motilin elicited phasic contractions in the whole colon (Strum et al 1975). Bickel and Belz (1988) reported that motilin administered intravenously evoked colonic motor complexes in the right half of the colon. Furthermore, the mechanism of the excitatory effect of motilin on colonic motility has not yet been elucidated in conscious dogs.…”

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confidence: 99%

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Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs.

Shibata

Sasaki

Naitö

et al. 1995

Tohoku J. Exp. Med.

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and MATSUNO, S. Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs. Tohoku J. Exp. Med., 1995, 176 (1), [53][54][55][56][57][58][59][60] The aim of the present study was to investigate the effect of motilin at various doses on colonic motility in the interdigestive state. Colonic motility was investigated in five dogs equipped with strain gauge force transducers on the gastric antrum, and on the proximal, middle, and distal colon. Exogenously infused motilin (0.2, 0.5, 1.0 and 2.01ug/kg-hr) dose-dependently increased colonic motility, but the doses of motilin that significantly enhanced colonic motility were 1.0 and 2.0 ,u g/kg-hr in all areas of the colon. Motilin at 0.2 ,u g/kg-hr increased the plasma motilin concentration to almost equal . to the physiological peak values. The excitatory effect of motilin (2.0 ,u g/kg-hr) was abolished by atropine but was not affected by hexamethonium. These results indicate that exogenously infused motilin, which increased plasma motilin concenration to above the physiological peak level, stimulated colonic motility by affecting postsynaptic cholinergic neurons, cholinergic neurons; colonic motor complexes; motilin It is well known that plasma motilin concentrations in the interdigestive state fluctuate cyclically; their peak coinciding with the end of interdigestive phase III contractions in the stomach (Itoh et al. 1978;Lee et al. 1978). Exogenously infused motilin at a physiological dose level evokes interdigestive phase III contractions in the stomach (Itoh et al. 1975(Itoh et al. , 1977.However, relationship between plasma motilin concentrations and occurrence of colonic motor complexes in the interdigestive state remains obscure; it is not known whether or not the physiological increase in the plasma motilin concentration actually is a physiological stimulus inducing colonic motor complexes in the interdigestive state. Considering the fact that the cycle of fluctuation in the plasma motilin concentration (90-120 min) (Itoh et al. 1978) is longer than the intervals of the occurrence of the colonic motor complexes in the fasted state (25-

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Section: Disucussioncontrasting

confidence: 57%

mentioning

confidence: 99%

Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs.

Shibata

Sasaki

Naitö

et al. 1995

Tohoku J. Exp. Med.

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“…19,21 Although animal models document the presence of motilin receptors in the colon, it is not certain whether they are present in the human colon. 20,[22][23][24][25][26] In physiologic quantities motilin acts to stimulate the MMC, and not postprandial activity. 2,18,19,21 Pharmacologic doses do, however, stimulate postprandial motility.…”

Section: Erythromycinmentioning

confidence: 99%

Prokinetic Agents for the Treatment of Postoperative Ileus in Adults: A Review of the Literature

Bungard

Kale-Pradhan

1999

Pharmacotherapy

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Metoclopramide, cisapride, and erythromycin are commonly administered to reduce the duration of postoperative ileus (POI). As these agents are not without potential adverse effects, their efficacy in shortening the duration of POI should be evaluated. The etiology of POI is not well understood and therefore the precise treatment is unclear. Nasogastric suction is the mainstay of therapy, and management of fluid and electrolyte imbalances is crucial. The role of prokinetic agents is less understood. Available literature evaluating these drugs specifically for POI were reviewed, but results are confounded by issues such as sample size, variability in types of operations performed, and insensitive end points (flatus, bowel sounds). No literature supports reducing the duration of POI with metoclopramide, and limited data show benefit with cisapride. Data evaluating erythromycin are sparse, and the drug is believed to be ineffective. Domperidone, a prokinetic agent not available in the United States, has not been evaluated in POI. Due to these limitations, treatment remains largely supportive with a limited role for prokinetic agents.

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“…infusion of motilin in conscious dogs (Shibata et al, 1995). Bickel and Belz (1988) also demonstrated that i. v. injection of motilin induced the colonic GMC in the entire right colon in dogs. On the other hand, the upper gastrointestinal contractile activity was strongly induced by mitemcinal from the lowest dose (0.1 mg/kg) in the present study, although mitemcinal induced no obvious changes in the colonic contractile activity at any site in the lowest dose.…”

Section: Discussionmentioning

confidence: 91%

“…Namely, the Phase III contractions of the MMC regularly occurred at gastric antrum and the duodenum in the interdigestive state; they migrated to the jejunum. In the colon, clusters of small contractions, called the colonic motor complexes (CMC, Bickel and Belz (1988)), were occurring during all the time without any silent period independently from the MMC that occurred in the upper gastrointestinal tract. Mitemcinal at an oral dose of 0.1 mg/kg induced strong contractions at the upper gastrointestinal tracts, but there were no obvious changes in colonic motility at any site (Fig.…”

Section: Effect Of Mitemcinal On Gastrointestinal Contractile Activitmentioning

confidence: 99%

Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs

Ozaki¹,

Sudo²,

Muramatsu³

et al. 2007

Inflammopharmacol

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The prokinetic effects of mitemcinal, an orally active motilin receptor agonist, on the lower gastrointestinal tracts were investigated in conscious dogs. Oral administration of mitemcinal (0.1-1 mg/kg) stimulated colonic motility, which was measured by chronically implanted force-transducers, as well as gastric motility in a dose-dependent manner. The gastrointestinal contractile activities induced by mitemcinal were inhibited by the continuous intravenous infusion of GM-109, a selective motilin receptor antagonist. Oral administration of mitemcinal (0.3-3 mg/kg) also accelerated bowel movement after feeding without inducing diarrhea in dogs. The results demonstrate that mitemcinal stimulates colonic motility via motilin receptors and the effect of mitemcinal on colonic motility may reflect bowel movement after feeding. Thus, mitemcinal could be a promising agent for treatment of not only the upper but also the lower gastrointestinal motility disorders.

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Motilin and a synthetic enkephalin induce colonic motor complexes (CMC) in the conscious dog

Cited by 19 publications

References 17 publications

Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs.

Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs.

Prokinetic Agents for the Treatment of Postoperative Ileus in Adults: A Review of the Literature

Mitemcinal (GM-611), an orally active motilin receptor agonist, accelerates colonic motility and bowel movement in conscious dogs

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