Mothers’ experiences of wellbeing and coping while living with rheumatoid arthritis: a qualitative study

Parton, Chloe; Ussher, Jane M.; Perz, Janette

doi:10.1186/s12905-022-01767-1

Cited by 5 publications

(1 citation statement)

References 47 publications

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“…In terms of the limits of this study, the authors understand that information about specific trivial infections carried during the year, and the number and duration of these infections, is subjective. However, a significant number of publications are based on the results of analysis of data obtained by quantitative interviews (175 publications in PubMed when searching for the keywords "rheumatoid arthritis" and "quantitative interviews"), some of which are based on online or phone surveys and information self-reported by patients [101][102][103][104][105]. In our study, information about annual infections was collected face-toface from year to year (up to 15 or more years of monitoring) by a qualified rheumatologist with extensive experience as a general practitioner and included the active use of information from medical records (about 30-40% of annual acute infections, 100% of exacerbation of chronic infections other than HSV, and 100% of pneumonia, TB, and contraction of sexual infections ever in life).…”

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confidence: 99%

At Early Rheumatoid Arthritis Stage, the Infectious Spectrum Is Driven by Non-Familial Factors and Anti-CCP Immunization

Arleevskaya,

Novikov,

Valeeva

et al. 2024

JCM

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Background/Objectives: Patients with rheumatoid arthritis (RA) are prone to develop infections. Methods: Accordingly, 195 untreated early (e)RA patients and 398 healthy controls were selected from women in Tatarstan’s cohort to study infectious history in the anamnesis (four criteria) and in the previous year (16 criteria). Information about annual infections was collected face-to-face from year to year by a qualified rheumatologist/ general practitioner and included the active use of information from medical records. Results: In the anamnesis, tuberculosis, and pneumonia, and in the previous year, respiratory tract infections, skin infections, and herpes simplex virus reactivation incidence were reported to be increased in eRA patients, as well as the event number and duration of acute and chronic tonsillitis. Moreover, more bacterial-suspected upper respiratory infections and urinary tract infections were retrieved in sporadic eRA patients as compared to familial eRA patients. An elevated immunization against CCP prevented respiratory tract infection in those with HSV exacerbation. Finally, associations were retrieved between infection (event number/delay) and RA indices: (i) chronic tonsillitis exacerbations with disease activity and health assessment (HAQ) in familial eRA; (ii) bacterial-suspected upper respiratory infections with the number of swollen and tender joints in sporadic eRA; and (iii) HSV exacerbation with inflammation in eRA patients with negative/low response against CCP. Here, we demonstrate the complex nature of the interplay of RA with specific infections. Conclusions: For the first time, differences in the patterns of annual trivial infections and their links with RA indices were found in cohorts of familial and sporadic cases of the disease. Additionally, for the first time, we identified a remarkable relationship between early RA and exacerbations of chronic tonsillitis, as well as tuberculosis in the patient’s history. Altogether, this study supports the existence of a complex interplay between infections and RA at onset driven by familial status and the presence of anti-CCP Ab at elevated levels.

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confidence: 99%