Mother-to-child transmission prevention of human immunodeficiency virus, syphilis and hepatitis B virus

Wu, Yinglan; Gao, Jie; Qin, Jiabi; He, Jian; Wang, Aihua; Wang, Hua; Du, Qianqian; Fang, Junqun; Sheng, Xiaoqi; Wang, Ruoping; Wang, Zhanghua; Yang, Tubao

doi:10.1016/j.wombi.2018.11.004

Cited by 11 publications

(13 citation statements)

References 20 publications

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“…There is still huge gap from the goal of eliminating mother-to-infant syphilis transmission by 95% set up by Worth Health Organization in 2014 22 . After the implementation of national PMTCT in China for 8 years, many studies have been made to report the implementation effects of this project, including the process indexes (prenatal syphilis screening rates, gestational syphilis treatment rates) and effect indexes (congenital syphilis occurrence) 2 , 3 , 10 , 20 . However, there is no report about the determinants on standardized treatment of gestational syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…The PMTCT implementation plan in 2011 recommended the therapeutic drug of benzathine penicillin or procaine penicillin, the replacement with ceftriaxone in the unavailability of penicillin, and the use of erythromycin for penicillin-allergic patients. Along with the implementation of PMTCT in China, the prenatal syphilis detection rate and treatment rate among pregnant women were significantly improved from 67.4 to 94.1% and from 58.8 to 89.4% respectively from 2012 to 2016 10 . However, the standardized treatment rates of syphilis were only less than 60% 6 , 10 , 11 , which severely reduced the mother-to-child transmission blocking effect.…”

Section: Introductionmentioning

confidence: 99%

“…Along with the implementation of PMTCT in China, the prenatal syphilis detection rate and treatment rate among pregnant women were significantly improved from 67.4 to 94.1% and from 58.8 to 89.4% respectively from 2012 to 2016 10 . However, the standardized treatment rates of syphilis were only less than 60% 6 , 10 , 11 , which severely reduced the mother-to-child transmission blocking effect. Hunan province initiated PMTCT among 21 counties in 2011, then extended to 48 counties in 2014 and covered all 123 counties in 2015.…”

Section: Introductionmentioning

confidence: 99%

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Standardized treatment and determinants on 9,059 syphilis-infected pregnant women during 2015–2018 in Hunan, China

Tan

Luo

et al. 2020

Sci Rep

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this study was aimed to describe the standardized treatment rate of syphilis-infected pregnant women in Hunan province and to explore the determinants for standardized treatment. All syphilisinfected pregnant women registered in the Information System of Prevention of Mother-to-Child Transmission of Syphilis Management (IPMTCT) in Hunan between January 2015 and December 2018 were included in this study. Among 9,059 pregnant women with syphilis, 7,797 received syphilis treatment, with a treatment rate of 86.1%, and 4,963 underwent standardized syphilis treatment, with an average standardized treatment rate of 54.8%. The facilitators for the standardized treatment included abnormal reproductive histories (

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Standardized treatment and determinants on 9,059 syphilis-infected pregnant women during 2015–2018 in Hunan, China

Tan

Luo

et al. 2020

Sci Rep

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“…During 2011–2020, the National Health Commission issued 3 versions of the “Protocol for Prevention of MTCT of HIV, syphilis, and hepatitis B,” which contained the government’s response strategy, intervention measures, and requirements regarding organization and management. As for HIV, in every protocol, standardized intervention services for PMTCT of HIV covered the following: HIV testing for pregnant women, free antiretroviral therapy or prophylaxis for pregnant women, antiretroviral prophylaxis for 6 or 12 weeks for children, HIV testing for children, and other interventions ( 6 ).…”

Section: Methodsmentioning

confidence: 99%

Prevention of Mother-To-Child Transmission of HIV — China, 2011–2020

Wang¹,

Wang²,

Wang³

et al. 2021

China CDC Weekly

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Introduction Prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) is a global health focus in most parts of the world. The World Health Organization (WHO) launched the dual Elimination of Mother-to-Child Transmission (EMTCT) of HIV and syphilis initiative and released global guidance on criteria and processes for validation of the EMTCT in 2014. The purpose of this report was to analyze the key validation indicators of EMTCT of HIV in China from 2011 to 2020 and to provide relevant basis information for the implementation of EMTCT action in China. Methods The report described the coverage of maternal HIV screening and antiretroviral therapy usage for HIV infected pregnant women and their infants in China using the data from the national information systems of PMTCT of HIV, syphilis, and HBV management from 2011 to 2020. Results The rates of maternal HIV testing during pregnancy (predelivery and at labor) and predelivery increased from 92.9% (8,730,161/9,398,781) and 53.7% (5,050,569/9,398,781) to 99.9% (11,964,026/11,982,321) and 97.5% (11,679,924/11,982,321), respectively. The MTCT rate reduced from 7.4% to 3.6% between 2011 and 2020. Conclusions The data from the surveillance systems revealed that there was a marked increase in the coverage of HIV screening of pregnant women and antiretrovirals drugs use for HIV infected pregnant women and their infants in China from 2011 to 2020.

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“…The addition of a birth dose of hepatitis B immunoglobulin for infants born to HBsAg positive mothers, and oral antiviral therapy during the third trimester of pregnancy for women with high HBV DNA have further reduced the mother to child transmission (MTCT) rate of HBV to nearly zero [3] . The ongoing triple elimination program for the prevention of MTCT of HIV, syphilis, and HBV will further reduce the prevalence of HBsAg in the young age group [4] …”

mentioning

confidence: 99%