Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis

Gołębiewski, Marcin; Łoś-Rycharska, Ewa; Sikora, Marcin; Grzybowski, Tomasz; Gorzkiewicz, Marta; Krogulska, Aneta

doi:10.3390/nu13103600

Cited by 19 publications

(9 citation statements)

References 43 publications

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“…The reduction of bifidobacteria in the human body and the increase of other bacteria have a certain relationship with the increase of age, but the bacteria that appear in different locations have different pathogenic properties [ 55 ]. With increasing age and gradual changes in eating habits, the intestinal microbiota in the human body will also change accordingly [ 56 , 57 ]. The influence of various factors changes the changes in the microbiota in the human body, and the composition of intestinal microbes will also be changed if drugs are used for treatment [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and atopic dermatitis in children: a scoping review

Liu¹,

Zhai³

et al. 2022

BMC Pediatr

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Background Gut microbiota plays an important role in the development of atopic dermatitis (AD). We aimed to elucidate research trends in gut microbiota and AD in children, to provide evidence and insights to the clinical prevention and treatment of AD in children. Methods A scoping literature review on the studies of gut microbiota and AD were conducted. Two authors independently searched Pubmed et al. databases for studies focused on gut microbiota and AD in children up to January 15, 2022. The literatures were screened and analyzed by two reviewers. Results A total of 44 reports were finally included and analyzed. Current researches have indicated that abnormal human microecology is closely associated with AD, and the disturbance of intestinal microbiota plays an important role in the occurrence and development of AD. Probiotics can correct the microbiota disorder, have the functions of regulating immunity, antioxidant, and help to restore the microecological homeostasis. However, there is still a lack of high-quality research reports on the efficacy and safety of probiotics in the prevention and treatment of AD in children. Conclusions The changes of gut microbiota are essential to the development of AD in children, which may be an effective target for the prevention and treatment of AD. Future studies with larger sample size and rigorous design are needed to elucidate the effects and safety of probiotics in AD.

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Section: Discussionmentioning

confidence: 99%

Gut microbiota and atopic dermatitis in children: a scoping review

Liu¹,

Zhai³

et al. 2022

BMC Pediatr

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“…As one of the most important sources providing the initial bacterial community, human breast milk is the optimal food for infants, while the feeding guidelines vary in different regions 177–179. Previous studies have confirmed the benefits of breast feeding for both mothers and infants 11 178 180 181. Through breast feeding, a variety of nutrients that are important in early life are transferred to infants (figure 4B).…”

Section: Microbial Transmission During and After Deliverymentioning

confidence: 95%

Microbial transmission, colonisation and succession: from pregnancy to infancy

Xiao

Zhao

2023

Gut

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The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of the microbiome and the corresponding immune mechanism between mothers and their offspring during the perinatal period. We aim to present a comprehensive picture of microbial transmission and potential immune imprinting before and after delivery. In addition, we discuss the possibility of in utero microbial colonisation during pregnancy, which has been highly debated in recent studies, and highlight the importance of the microbiome in infant development during the first 3 years of life. This holistic view of the role of the microbial interplay between mothers and infants will refine our current understanding of pregnancy complications as well as diseases in early life and will greatly facilitate the microbiome-based prenatal diagnosis and treatment of mother-infant-related diseases.

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“…However, to our knowledge, no studies exist on the direct transfer of commensal skin bacteria to milk or breast tissue, and it remains unclear if microbial taxa can enter healthy nipple or areola tissue. On the other hand, human studies have shown that milk microbiomes are linked to variation in infant skin and gut microbiomes, which may be related to their incidence of allergy (Gołębiewski et al 2021).…”

Section: Milk Microbiome Formationmentioning

confidence: 99%

Microbiome: Mammalian milk microbiomes: sources of diversity, potential functions, and future research directions

Power,

Muletz-Wolz,

Bornbusch

2024

Reproduction and Fertility

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Milk is an ancient, fundamental mammalian adaptation providing nutrition and biochemical communication to offspring. Microbiomes have been detected in milks of all species studied to date. In this review, we discuss (a) routes by which microbes may enter milk, (b) evidence for proposed milk microbiome adaptive functions, (c) variation in milk microbiomes across mammals, and (d) future research directions, including suggestions for how to address outstanding questions on the viability and functionality of milk microbiomes. Milk microbes may be sourced from maternal gastrointestinal tract, oral, skin, and mammary gland microbiomes and from neonatal oral and skin microbiomes. Given the variety of microbial sources, stochastic processes strongly influence milk microbiome assembly, but milk microbiomes appear to be influenced by maternal evolutionary history, diet, environment, and milk nutrients. Milk microbes have been proposed to colonize the neonatal intestinal tract and produce gene and metabolic products that influence physiology, metabolism, and immune system development. Limited epidemiological data indicate that early-life exposure to milk microbes can result in positive, long-term health outcomes. Milk microbiomes can be modified by dietary changes including providing the mother with probiotics and prebiotics. Milk replacers (i.e., infant formula) may benefit from supplementation with probiotics and prebiotics, but data are lacking on probiotics usefulness and supplementation should be evidence-based. Overall, milk microbiome literature outside of human and model systems is scarce. We highlight the need for mechanistic studies in model species paired with comparative studies across mammals to further our understanding of mammalian milk microbiome evolution. Broader study of milk microbiomes has the potential to inform animal care with relevance to ex-situ endangered species.

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Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis

Cited by 19 publications

References 43 publications

Gut microbiota and atopic dermatitis in children: a scoping review

Gut microbiota and atopic dermatitis in children: a scoping review

Microbial transmission, colonisation and succession: from pregnancy to infancy

Microbiome: Mammalian milk microbiomes: sources of diversity, potential functions, and future research directions

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