Mother-Infant Interactions in Rats Lacking CCKA Receptors.

Lavi-Avnon, Yael; Malkesman, Oz; Hurwitz, Itay; Weller, Aron

doi:10.1037/0735-7044.118.2.282

Cited by 14 publications

(11 citation statements)

References 76 publications

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“…Weller and colleagues (Lavi-Avnon et al 2004;Blumberg et al 2005) have examined aspects of the development of ingestive behaviours in OLETF rats. OLETF pups consumed more sweetened milk than LETO control pups in an independent ingestion test in which pups lick milk off a filter paper on the floor of the test chamber.…”

Section: Ingestion In Preweanling Oletf Pupsmentioning

confidence: 99%

Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors

Moran

2006

Phil. Trans. R. Soc. B

112

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The brain-gut peptide cholecystokinin (CCK) inhibits food intake following peripheral or site directed central administration. Peripheral exogenous CCK inhibits food intake by reducing the size and duration of a meal. Antagonist studies have demonstrated that the actions of the exogenous peptide mimic those of endogenous CCK. Antagonist administration results in increased meal size and meal duration. The feeding inhibitory actions of CCK are mediated through interactions with CCK-1 receptors. The recent identification of the Otsuka-Long-Evans-Tokushima Fatty (OLETF) rat as a spontaneous CCK-1 receptor knockout model has allowed a more comprehensive evaluation of the feeding actions of CCK. OLETF rats become obese and develop non-insulin dependent diabetes mellitus (NIDDM). Consistent with the absence of CCK-1 receptors, OLETF rats do not respond to exogenous CCK. OLETF rats are hyperphagic and their increased food intake is characterized by a large increase in meal size with a decrease in meal frequency that is not sufficient to compensate for the meal size increase. Deficits in meal size control are evident in OLETF rats as young as 2 days of age. OLETF obesity is secondary to the increased food intake. Pair feeding to amounts consumed by intact control rats normalizes body weight, body fat and elevated insulin and glucose levels. Hypothalamic arcuate nucleus peptide mRNA expression in OLETF rats is appropriate to their obesity and is normalized by pair feeding. In contrast, pair fed and young pre-obese OLETF rats have greatly elevated dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) mRNA expression. Elevated DMH NPY in OLETF rats appears to be a consequence of the absence of CCK-1 receptors. In intact rats NPY and CCK-1 receptors colocalize to neurons within the compact subregion of the DMH and local CCK administration reduces food intake and decreases DMH NPY mRNA expression. We have proposed that the absence of DMH CCK-1 receptors significantly contributes to the OLETF's inability to compensate for their meal size control deficit leading to their overall hyperphagia. Access to a running wheel and the resulting exercise normalizes food intake and body weight in OLETF rats. When given access to running wheels for 6 weeks shortly after weaning, OLETF rats do not gain weight to the same degree as sedentary OLETF rats and do not develop NIDDM. Exercise also prevents elevated levels of DMH NPY mRNA expression, suggesting that exercise exerts an alternative, non-CCK mediated, control on DMH NPY. The OLETF rat is a valuable model for characterizing actions of CCK in energy balance and has provided novel insights into interactions between exercise and food intake.

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Section: Ingestion In Preweanling Oletf Pupsmentioning

confidence: 99%

Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors

Moran

2006

Phil. Trans. R. Soc. B

112

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“…Recently, a few studies in our lab demonstrated differential body weight already from birth (Schroeder, Zagoory-Sharon, Lavi-Avnon, & Weller, 2005; Schroeder, Zagoory-Sharon, Lavi-Avnon, Moran, & Weller, 2006); different independent ingestion patterns already on postnatal days (PND) 2-4 and 9-11 (Blumberg, Haba, Schroeder, Smith, & Weller, 2006), different patterns of infant distress reactivity (Hurwitz et al, 2006) and of maternal and nursing behavior (Lavi-Avnon, Malkesman, Hurwitz, & Weller, 2004;Schroeder et al, 2005) compared to the control strain, Long Evans Tokushima Otsuka (LETO).…”

Section: Introductionmentioning

confidence: 97%

Diurnal and nocturnal nursing behavior in the OLETF rat

Schroêder

Lavi-Avnon

Dagan

et al. 2007

Developmental Psychobiology

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The Otsuka Long Evans Tokushima Fatty (OLETF) rat model of obesity has been recently found to develop hyperphagia and obesity early in life. Our goal was to investigate the dams' nursing behavior during the day and the night in order to elucidate their contribution to the pre-obesity of the pups. We examined nursing bout number, length, posture, initiative, nursing total time and frequency of other maternal behaviors over the three postpartum (PP) weeks. In the first week, OLETF dams nursed more during the day and presented more self-directed activities during the night. In the third PP week, OLETF dams displayed increased nursing time, bout number, nursing frequency, and supine postures at the beginning of the nursing episodes and less active self-directed behaviors, both day and night, while OLETF pups displayed more initiative in starting nursing bouts. The results suggest a circadian difference in nursing behavior and self-directed activities between the strains on PP week 1 and a strong influence of the OLETF pups on the nursing behavior of the dam on PP week 3, which contributes to their obese features.

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“…In addition to these differences between the pups, there is disparity in the behavior of OLETF and LETO dams that may contribute to the difference in the rate of weight gain of the offspring. OLETF dams spend more time nursing (Schroeder et al, 2007a) and behave differently than LETO dams when interacting with one pup (Lavi-Avnon, Malkesman, Hurwitz, & Weller, 2004). …”

Section: Introductionmentioning

confidence: 99%

Examining maternal influence on OLETF rats' early overweight: Insights from a cross‐fostering study

Schroêder

Schechter

Fride

et al. 2009

Developmental Psychobiology

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Obese female Otsuka Long Evans Tokushima Fatty (OLETF) rats display increased nursing time and frequency compared to lean LETO controls, suggesting a maternal contribution to pup preobesity. In previous studies, OLETF pups presented high adiposity, showed greater suckling efficiency, initiative and weight gain from nursing than controls throughout lactation. To further elucidate maternal-infant interactions contributing to pup preobesity, we cross-fostered pups a day after birth and examined maternal behavior. Nursing frequency decreased in OLETF dams raising LETO pups (OdLp) in the third postnatal week, while LETO dams raising OLETF pups showed no significant changes. Fat % was greater in the milk of OLETF versus LETO dams. OdLp pups showed long-term body weight (BW) increase, suggesting that maternal environment can induce BW increases even in the absence of a genetic tendency. Additionally, interaction between OLETF dams and pups produces high nursing frequency, exposing the pups to abundant high-fat milk, thus strengthening their preobese phenotype. ß 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 358-366, 2009.

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Mother-Infant Interactions in Rats Lacking CCKA Receptors.

Cited by 14 publications

References 76 publications

Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors

Hyperphagia and obesity in OLETF rats lacking CCK-1 receptors

Diurnal and nocturnal nursing behavior in the OLETF rat

Examining maternal influence on OLETF rats' early overweight: Insights from a cross‐fostering study

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