Mother-child vitamin D deficiency: an international perspective

Dawodu, Adekunle; Wagner, Carol L.

doi:10.1136/adc.2007.122689

Cited by 158 publications

(148 citation statements)

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“…The lower levels of 25(OH)D concentrations may be as a result of increased fetal demand for this essential nutrient which is almost entirely dependent on vitamin D from the mother. 17,18 Widespread prevalence of hypovitaminosis D among adolescent girls and pregnant and post-natal women in Saudi Arabia and around the world has also been reported in several studies, which is in accordance with the result of present study. 19 In the human body, about 50-90% of vitamin D comes from the biosynthesis of vitamin D3 (cholecalciferol) in the skin from 7-dehydrocholesterol that requires sunlight (ultraviolet radiation), and the remainder comes from a limited number of foods (mainly fatty fish, eggs, and liver as well as foods fortified with vitamin D such as margarine, cereals, and milk products) and from dietary supplements.…”

Section: Discussionsupporting

confidence: 82%

Assessment of Vitamin D and its Correlation with Lipid Markers among Adult Female during the Course of Pregnancy in and Around Dhanbad, Jharkhand

Kumari¹,

Kumar²,

Sharan³

2018

IJCMR

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Introduction: Vitamin D deficiency is one of the common health issue and is widespread throughout the world. It's dietary supplementation is generally advised in the general population, including pregnant women. However, data about the relation between vitamin D status and the lipid profile in adult females during pregnancy is inconsistent. The present study was designed with the aim to assess the status of vitamin D and its relationship with the serum lipid profile in the females during pregnancy in and around Dhanbad Jharkhand.

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Section: Discussionsupporting

confidence: 82%

Assessment of Vitamin D and its Correlation with Lipid Markers among Adult Female during the Course of Pregnancy in and Around Dhanbad, Jharkhand

Kumari¹,

Kumar²,

Sharan³

2018

IJCMR

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“…The incidence of maternal vitamin D deficiency was reported to be between 18% and : chi-square test (P < 0.05), data are given as median (minimum-maximum), BMI: body mass index. 84% in studies from different countries that accepted a level of 25(OH)D of <10 ng/mL as vitamin D deficiency (16)(17)(18)(19). In the study by Andiran et al performed in 2002 in Ankara, the rate of vitamin D deficiency (<10 ng/ mL) was found to be 46% and 80% in mothers and their babies, respectively (20).…”

Section: Discussionmentioning

confidence: 99%

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

GÜR¹,

Abacı²,

KÖKSOY³

et al. 2014

Turk J Med Sci

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A greenhouse experiment was conducted to observe the effects of Bacillus megaterium strain TV-91C, Pantoea agglomerans strain RK-92, and B. subtilis strain TV-17C inoculation on the growth, nutrient, and hormone content of cabbage seedlings. The seeds of cabbage were incubated in flasks by shaking at 80 rpm for 2 h at 28 °C to coat the seeds with the rhizobacteria. Plant growth-promoting rhizobacteria (PGPR) treatments increased fresh and dry shoot and root weight, stem diameter, seedling height, chlorophyll reading values, and leaf area of cabbage seedlings compared with the control. Among the strains, B. megaterium TV-91C gave the greatest seedling nutrient content and growth parameters, although the maximum values for leaf area, gibberellic acid, salicylic acid, and indole acetic acid (IAA) contents of seedlings were obtained with the P. agglomerans RK-92 treatment. Seed inoculation with B. megaterium TV-91C increased fresh and dry shoot and root weight by 32.9%, 22.6%, 16.0%, and 35.69%, respectively. Inoculations also increased the stem diameter, seedling height, and SPAD chlorophyll values by 47.5%, 27.2%, and 5.8%, respectively. Furthermore, compared to the control, P. agglomerans RK-92 increased gibberellic acid, salicylic acid, IAA, and leaf area by 13.9%, 70.9%, 38.5%, and 27.3%, respectively. PGPR treatments may improve seedling growth and quality in cabbages.

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“…The resulting consequences to the fetus and the newborn include low cord blood (CB) vitamin D and high alkaline phosphatase (ALP), neonatal hypocalcaemia and poor fetal growth, among others (2,3) . Thus, pharmacological supplementation may be necessary, especially in such vulnerable groups.Although several studies are available on vitamin D supplementation during pregnancy, its appropriate dose is not clear (4) . In a study by Datta et al (5) , 160 pregnant Asian women in the UK were supplemented with a dose of 20 mg/d, which was later increased to 40 mg/d.…”

mentioning

confidence: 99%

Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant

et al. 2012

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Hypovitaminosis D is common in India. In the present prospective partially randomised study of vitamin D (D 3 ) supplementation during pregnancy, subjects were randomised in the second trimester to receive either one oral dose of 1500 mg vitamin D 3 (group 1, n 48) or two doses of 3000 mg vitamin D 3 each in the second and third trimesters (group 2, n 49). Maternal 25-hydroxyvitamin D (25(OH)D) at term, cord blood (CB) alkaline phosphatase (ALP), neonatal serum Ca and anthropometry were measured in these subjects and in forty-three non-supplemented mother -infant pairs (usual care). Median maternal 25(OH)D at term was higher in group 2 (58·7, interquartile range (IQR) 38·4 -89·4 nmol/l) v. group 1 (26·2, IQR 17·7-57·7 nmol/l) and usual-care group (39·2, IQR 21·2 -73·4 nmol/l) (P¼ 0·000). CB ALP was increased ( . 8.02 mkat/l or .480 IU/l) in 66·7 % of the usual-care group v. 41·9 % of group 1 and 38·9 % of group 2 (P¼0·03). Neonatal Ca and CB 25(OH)D did not differ significantly in the three groups. Birth weight, length and head circumference were greater and the anterior fontanelle was smaller in groups 1 and 2 (3·08 and 3·03 kg, 50·3 and 50·1 cm, 34·5 and 34·4 cm, 2·6 and 2·5 cm, respectively) v. usual care (2·77 kg, 49·4, 33·6, 3·3 cm; P¼0·000 for length, head circumference and fontanelle and P¼ 0·003 for weight). These differences were still evident at 9 months. We conclude that both 1500 mg and two doses of 3000 mg vitamin D 3 had a beneficial effect on infant anthropometry, the larger dose also improving CB ALP and maternal 25(OH)D.Key words: Vitamin D supplementation: Pregnancy: Infant anthropometry: Neonatal calcium Vitamin D deficiency has been reported to be frequent among adolescent girls and pregnant women in India, with approximately 80 % of both urban and rural subjects having serum 25-hydroxyvitamin D (25(OH)D) ,50 nmol/l (1,2) . Exposure to the abundant sunlight in India is poor in women because of the traditional modest style of dressing. The resulting consequences to the fetus and the newborn include low cord blood (CB) vitamin D and high alkaline phosphatase (ALP), neonatal hypocalcaemia and poor fetal growth, among others (2,3) . Thus, pharmacological supplementation may be necessary, especially in such vulnerable groups.Although several studies are available on vitamin D supplementation during pregnancy, its appropriate dose is not clear (4) . In a study by Datta et al. (5) , 160 pregnant Asian women in the UK were supplemented with a dose of 20 mg/d, which was later increased to 40 mg/d. However, the rise in maternal serum 25(OH)D was from 14·98 nmol/l to only 27·5 nmol/l. Similar results have been found in other studies that administered small daily doses of similar magnitude (6,7) , though one study (3) found significantly improved CB 25(OH)D in subjects receiving 25 mg/d when compared with controls. Studies that used larger (stoss) doses have done so only in the third trimester, whereas Ca transfer to the fetus has been shown to occur in the second trimester (8) . Marya et al. (...

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Mother-child vitamin D deficiency: an international perspective

Cited by 158 publications

References 73 publications

Assessment of Vitamin D and its Correlation with Lipid Markers among Adult Female during the Course of Pregnancy in and Around Dhanbad, Jharkhand

Assessment of Vitamin D and its Correlation with Lipid Markers among Adult Female during the Course of Pregnancy in and Around Dhanbad, Jharkhand

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant

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