Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome

Weisman, Omri; Feldman, Ruth; Burg-Malki, Merav; Keren, Miri; Geva, Ronny; Diesendruck, Gil; Gothelf, Doron

doi:10.1007/s10803-015-2425-6

Cited by 25 publications

(17 citation statements)

References 58 publications

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“…The CIB has shown construct and predictive validity, test–retest reliability and sensitivity to cultural contexts, interacting partner, and multiple psychopathological conditions (for a review see Feldman, 2012b). Consistent with prior research, we used three CIB constructs; Reciprocity, Empathy and Withdrawal (Feldman et al , 2013b, 2014; Schneiderman et al , 2014; Weisman et al , 2015; Apter-Levi et al , 2016), each computed by averaging several CIB codes. The Reciprocity composite included the following codes: recognition, elaboration, affect synchrony, containment, constancy, warmth and support.…”

Section: Methodsmentioning

confidence: 99%

Perception of social synchrony induces mother–child gamma coupling in the social brain

Lévy

Goldstein

Feldman

2017

Social Cognitive and Affective Neuroscience

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The recent call to move from focus on one brain’s functioning to two-brain communication initiated a search for mechanisms that enable two humans to coordinate brain response during social interactions. Here, we utilized the mother–child context as a developmentally salient setting to study two-brain coupling. Mothers and their 9-year-old children were videotaped at home in positive and conflictual interactions. Positive interactions were microcoded for social synchrony and conflicts for overall dialogical style. Following, mother and child underwent magnetoencephalography while observing the positive vignettes. Episodes of behavioral synchrony, compared to non-synchrony, increased gamma-band power in the superior temporal sulcus (STS), hub of social cognition, mirroring and mentalizing. This neural pattern was coupled between mother and child. Brain-to-brain coordination was anchored in behavioral synchrony; only during episodes of behavioral synchrony, but not during non-synchronous moments, mother’s and child's STS gamma power was coupled. Importantly, neural synchrony was not found during observation of unfamiliar mother-child interaction Maternal empathic/dialogical conflict style predicted mothers’ STS activations whereas child withdrawal predicted attenuated STS response in both partners. Results define a novel neural marker for brain-to-brain synchrony, highlight the role of rapid bottom-up oscillatory mechanisms for neural coupling and indicate that behavior-based processes may drive synchrony between two brains during social interactions.

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Section: Methodsmentioning

confidence: 99%

Perception of social synchrony induces mother–child gamma coupling in the social brain

Lévy

Goldstein

Feldman

2017

Social Cognitive and Affective Neuroscience

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“…Interestingly, children at risk or with ASD show reduced preference for infantdirected speech (Watson et al, 2012), this impacting negatively on language skills at later ages (Nadig et al, 2007;Paul et al, 2007;Watson et al, 2010). Evidence about WS children is not available, but compared to children with 22q11.2 Deletion syndrome, who commonly exhibit autistic features (Ousley et al, 2017), they express more positive emotions towards their mothers in a conflict interaction, higher levels of child's engagement, and enhanced reciprocity (Weisman et al, 2015).…”

Section: Ws Domestication and Language Evolutionmentioning

confidence: 99%

Williams syndrome, human self-domestication, and language evolution

Niego¹,

Benítez‐Burraco²

2018

Preprint

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Language evolution resulted from changes in our biology, behavior, and culture. One source of these changes might be human self-domestication. Williams syndrome (WS) is a clinical condition with a clearly defined genetic basis and resulting in a distinctive behavioral and cognitive profile, including enhanced sociability. In this paper we show evidence that the WS phenotype can be satisfactorily construed as a hyper-domesticated human phenotype, plausibly resulting from the effect of the WS hemydeletion on several candidates for domestication and neural crest function. We also discuss the consequences of this link between domestication and WS for our current understanding of language evolution.

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“…Both syndromes have overlapping phenotypic manifestations, including cardiovascular anomalies, calcium dysregulation, cognitive deficits and high rates of psychiatric comorbidities (Campbell et al, 2009). As a group, individuals with neurodevelopmental disabilities (e.g., 22q11DS, WS, fragile X, or Turner syndrome) have higher rates of neuropsychiatric, cognitive and social-behavioral deficits including nonverbal learning disorder, visuospatial deficits, attention deficit/hyperactivity disorder (ADHD), anxiety disorders and affective disorders, compared to typically developing (TD) individuals (Schneider et al, 2014; Siegel and Smith, 2011; Weisman et al, 2015; Zarchi et al, 2014). Additionally, individuals with 22q11.2DS have a 30-fold increased risk of developing psychosis compared to TD individuals and individuals with other neurodevelopmental disabilities (10-fold) (Schneider et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Negative subthreshold psychotic symptoms distinguish 22q11.2 deletion syndrome from other neurodevelopmental disorders: A two-site study

Mekori‐Domachevsky

Guri

et al. 2017

Schizophrenia Research

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About one-third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop schizophrenia. Notably, a full-blown psychotic disorder is usually preceded by subthreshold symptoms. Therefore, it is important to identify early signs of psychosis in this population, a task that is complicated by the intellectual disabilities typically seen in 22q11.2DS. We aimed to identify subthreshold psychotic symptoms that distinguish 22q11.2DS from other neurodevelopmental disorders. The study included two independent cohorts from Tel Aviv and Philadelphia. 22q11.2DS (N=171) and typically developing (TD; N=832) individuals were enrolled at both sites and further compared to two groups with intellectual disabilities: Williams syndrome (WS; N=21) in the Tel Aviv cohort and idiopathic developmental disabilities (IDD; N=129) in the Philadelphia cohort. Participants and their primary caregivers were interviewed with the Structured Interview for Prodromal Symptoms (SIPS) and psychopathologies were assessed using standardized tools; general cognitive abilities were assessed with the Computerized Neurocognitive Battery. Negative/disorganized subthreshold syndrome was significantly more common in the 22q11.2DS group than in the WS (OR=3.90, 95% CI=1.34–11.34) or IDD (OR=5.05, 95% CI=3.01–10.08) groups. The 22q11.2DS group had higher scores than the two intellectual disabilities groups on several SIPS negative items, including avolition and decreased expression of emotion. Overall, there were few significant correlations between level of cognitive deficits and severity of negative symptoms in 22q11.2DS and only in the Tel Aviv cohort. Our findings suggest that 22q11.2DS individuals at the age of risk for developing psychosis should be closely monitored for negative symptoms.

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Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome

Cited by 25 publications

References 58 publications

Perception of social synchrony induces mother–child gamma coupling in the social brain

Perception of social synchrony induces mother–child gamma coupling in the social brain

Williams syndrome, human self-domestication, and language evolution

Negative subthreshold psychotic symptoms distinguish 22q11.2 deletion syndrome from other neurodevelopmental disorders: A two-site study

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