Most used photobiomodulation dosimetry parameters to treat oral mucositis after preconditioning for hematopoietic stem cell transplantation: systematic review and meta-analysis

Silva, Bruna Machado Da; Prosdócimo, Maria Luiza; Gasparini, Larissa Rodrigues; Silva, Betânia Machado da; Araujo, Melissa Rodrigues de; Amenábar, José Miguel

doi:10.1007/s00520-022-06817-w

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…An intra-oral approach was employed more often than a combined intra and extra-oral approach. We found great variability in PBM protocols, as previously reported [1,13]. Most responders used wavelengths ∼650 nm (range 630-670 nm), also consistent with the literature [13].…”

Section: Discussionsupporting

confidence: 89%

“…PBM was used for both prevention and treatment of established OM, most protocols used wavelength of 645 nm and 660 nm, with an intra-oral approach. This aligns with the results of this survey for adults as well as with those reported in the literature for pediatric patients [1,13,15]. PBM therapy may be regarded as a patient-friendly treatment option for pediatric patients who may find it difficult to adhere to other therapeutic interventions.…”

Section: Discussionsupporting

confidence: 89%

“…We found great variability in PBM protocols, as previously reported [1,13]. Most responders used wavelengths ∼650 nm (range 630-670 nm), also consistent with the literature [13]. This may reflect the wavelengths that are emitted by the commercially available laser devices, and not necessarily the preferences of the clinician.…”

Section: Discussionsupporting

confidence: 88%

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Clinical Use of Photobiomodulation for the Prevention and Treatment of Oral Mucositis: The Real-life Experience of MASCC/ISOO Members

ABDALLA-ASLAN,

ZADIK,

INTRATOR

et al. 2023

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 89%

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Clinical Use of Photobiomodulation for the Prevention and Treatment of Oral Mucositis: The Real-life Experience of MASCC/ISOO Members

ABDALLA-ASLAN,

ZADIK,

INTRATOR

et al. 2023

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…By delivering the proper dosage, ideal therapeutic effects can be achieved while also maintaining maximum patient safety and care. PBM dosimetry has only been recently studied in more detail [12] and this study was completed to provide more information on the effects of optical properties on PBM dosimetry.…”

Section: Introductionmentioning

confidence: 99%

Red and near-infrared light dosimetry: a comprehensive analysis of tissue optical properties

Yang,

Sourvanos,

Johnson

et al. 2024

Mechanisms of Photobiomodulation Therapy XVIII

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Photobiomodulation (PBM) dosimetry incorporates various irradiation parameters such as wavelength, beam area/spot size, power, fluence, irradiance, time, treatment duration, and optical properties of tissue. Among all those parameters, the optical properties, such as absorption coefficients (μa) and scattering (μs) of tissue, are the key components of determining PBM dosimetry. The absorption coefficient is primarily determined by the concentration and spectral characteristics of chromophores within the tissue. Consequently, wavelengths strongly absorbed by chromophores like hemoglobin or water may not penetrate deeply into tissue, making them inefficient for treating deeper targets. The scattering coefficient provides insight into the degree of light scattering due to interactions with tissue or inhomogeneities in the medium. In cases of high tissue scattering, a higher input dose may be necessary to ensure adequate energy density at the target site. We have studied the optical properties of pig jaws in seven different locations using contact probe developed at the University of Pennsylvania. The pig jaw is an excellent model for the human jaw since it has similar size and optical properties. Understanding the optical properties of the human jaw is the critical step for more precise and effective treatment of PBM in dental applications. This research aims to advance the understanding of the critical relationships between tissue optical properties absorption (μa) and scattering (μs), and the optimal dosimetry parameters for PBM, to enhance clinical outcomes. This highlights the importance of the PBM irradiation parameter variables and their influence on therapeutic efficacy.

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“…Several systematic reviews have confirmed photobiomodulation therapy's effectiveness for preventing and treating oral mucositis [13][14][15][16]. However, the effects of PBM at the cellular level and the biochemical response, especially of the cytokines, still need to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of Photobiomodulation on Salivary Cytokines in Head and Neck Cancer Patients with Oral Mucositis: A Systematic Review

Khalil,

Hamadah,

Saifo

et al. 2024

JCM

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Background: Oral mucositis is a common and distressing side effect of head and neck oncology treatment. Photobiomodulation therapy can be utilized to prevent and treat oral mucositis. Its impact on salivary cytokines has yet to be thoroughly investigated. This is the first systematic review aiming to evaluate the effect of photobiomodulation on salivary cytokines in patients undergoing anticancer treatment. Methods: Numerous data resources, from the Web of Science, Embase, ScienceDirect, PubMed, Cochrane Library, and Scopus were sought. Articles published up until February 2024 were included if they met the following inclusion criteria: clinical trials reporting the effect on salivary cytokines in patients undergoing anticancer therapy. The methodological quality was assessed using several appraisal tools. Results: Four studies were deemed eligible for inclusion. All the studies were conducted in Brazil and used an InGaAlP diode laser with a wavelength of 660 nm. The included studies had a relatively low risk of bias. The head and neck cancer patients’ salivary cytokines that were assessed by the studies, along with photobiomodulation therapy, included IL-12p70, TNF-α, IL-6, IL-8, IL-10, CXCL8, and IL-1β. The results varied among the studies. Conclusions: Our results show that photobiomodulation demonstrated positive results for reducing the severity of OM in all the included studies. Among the examined salivary cytokines, IL-6 is the most relevant cytokine for oral mucositis development and severity. A variation in the cytokine levels between the studies was noted due to differences in the type of anticancer treatment and saliva sampling.

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Most used photobiomodulation dosimetry parameters to treat oral mucositis after preconditioning for hematopoietic stem cell transplantation: systematic review and meta-analysis

Cited by 7 publications

References 27 publications

Clinical Use of Photobiomodulation for the Prevention and Treatment of Oral Mucositis: The Real-life Experience of MASCC/ISOO Members

Clinical Use of Photobiomodulation for the Prevention and Treatment of Oral Mucositis: The Real-life Experience of MASCC/ISOO Members

Red and near-infrared light dosimetry: a comprehensive analysis of tissue optical properties

Effect of Photobiomodulation on Salivary Cytokines in Head and Neck Cancer Patients with Oral Mucositis: A Systematic Review

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