Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome

Bishop, Colin E.; Boursot, Pierre; Baron, Bruno; Bonhomme, François; Hatat, D.

doi:10.1038/315070a0

Cited by 216 publications

(124 citation statements)

References 16 publications

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“…The aim of such comparative analysis is to identify conserved, functionally transcribed sequences such as protein-coding genes and non-coding RNA genes, and other functional sequences such as regulatory regions 4,5 , as well as other genomic features. Here, we have compared the entire human chromosome 21 with syntenic regions of the mouse genome, and have identified a large number of conserved blocks of unknown function.…”

Section: Determination Of Snp Low-and High-rate Regionsmentioning

confidence: 99%

“…As a result, we would expect to see in these strains recognizable contributions from several other subspecies such as M. m. musculus (and possibly M. m. castaneus through the hybrid M. m. molossinus). Indeed, most of these inbred laboratory strains carry a M. m. musculus Y chromosome 4 (previous work had shown that most carry M. m. domesticus mitochondrial DNA 5,6 ).…”

mentioning

confidence: 99%

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The mosaic structure of variation in the laboratory mouse genome

Wade

Kulbokas

Kirby

et al. 2002

Nature

431

376

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Most inbred laboratory mouse strains are known to have originated from a mixed but limited founder population in a few laboratories 1,2 . However, the effect of this breeding history on patterns of genetic variation among these strains and the implications for their use are not well understood. Here we present an analysis of the fine structure of variation in the mouse genome, using single nucleotide polymorphisms (SNPs). When the recently assembled genome sequence from the C57BL/6J strain 3 is aligned with sample sequence from other strains, we observe long segments of either extremely high (,40 SNPs per 10 kb) or extremely low (,0.5 SNPs per 10 kb) polymorphism rates. In all strain-to-strain comparisons examined, only one-third of the genome falls into long regions (averaging >1 Mb) of a high SNP rate, consistent with estimated divergence rates between Mus musculus domesticus and either M. m. musculus or M. m. castaneus. These data suggest that the genomes of these inbred strains are mosaics with the vast majority of segments derived from domesticus and musculus sources. These observations have important implications for the design and interpretation of positional cloning experiments.Patterns of genetic variation provide insight into the evolutionary history of a species and define the complexity of mapping phenotypes in that organism. The commonly used inbred laboratory strains of mice constitute the primary mammalian model system and are an integral component of medical genetic research. These inbred laboratory strains were predominantly derived in the early twentieth century from mouse breeders who originally bred 'fancy' mice (for unusual coat colours and behaviours) as a hobby. Many of the most commonly used strains trace their origins to W. Castle's laboratory at Harvard University and even more strains originate from his supplier A. Lathrop of Granby, Massachusetts. Although these mice are generally thought to reflect predominantly the M. m. domesticus subspecies, there are some historical contributions from 'fancy' mice bred in Japan and China 1,2 (Fig. 1a). As a result, we would expect to see in these strains recognizable contributions from several other subspecies such as M. m. musculus (and possibly M. m. castaneus through the hybrid M. m. molossinus). Indeed, most of these inbred laboratory strains carry a M. m. musculus Y chromosome 4 (previous work had shown that most carry M. m. domesticus mitochondrial DNA 5,6 ).

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Section: Determination Of Snp Low-and High-rate Regionsmentioning

confidence: 99%

mentioning

confidence: 99%

The mosaic structure of variation in the laboratory mouse genome

Wade

Kulbokas

Kirby

et al. 2002

Nature

431

376

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show abstract

“…Different molecular markers suggest that the main contributors are M. musculus musculus (Bishop et al 1985), M. musculus domesticus (Yonekawa et al 1982;Sakai et al 2005), and, to a lesser extent, M. musculus castaneus (Sakai et al 2005). One other subspecies that is usually considered to have contributed is M. musculus molossinus (Sakai et al 2005), although this itself is supposed to be a hybrid between M. m. musculus and M. m. castaneus (Lundrigan et al 2002;Wade et al 2002).…”

mentioning

confidence: 99%

mtDNA phylogeny and evolution of laboratory mouse strains

Goios¹,

Pereira²,

Bogue³

et al. 2007

Genome Res.

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Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different mouse subspecies. Although genealogies have been established, female inbred mouse phylogenies remain unexplored. By a phylogenetic analysis of newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common inbred strains descend from the same Mus musculus domesticus female wild ancestor, and suggest that they present a different mitochondrial evolutionary process than their wild relatives with a faster accumulation of replacement substitutions. Our data complement forthcoming results on resequencing of a group of priority strains, and they follow recent efforts of the Mouse Phenome Project to collect and make publicly available information on various strains.

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“…Such sporadic occurrences of foreign genes are most probably due to secondary imigration linked to human activity. Although the possibility that they result from the persistence of an ancestral polymorphism could be ruled out by a phylogenetic analysis in the case of mtDNA (Yonekawa et a!., 1988) this is not possible with our Y data as no intrasubspecies variation was detected, either in our Asian study or in extensive surveys of European populations (Bishop et a!., 1985, Vanlerberghe et al, 1986.…”

Section: Bgrmentioning

confidence: 58%

“…domesticus and M. in. musculus (Bishop et a!., 1985). Using this property, it was possible to show that there was a sharp transition from one Y-type to the other across the hybrid zone between these two subspecies.…”

Section: Introductionmentioning

confidence: 91%

Variations of a Y chromosome repeated sequence across subspecies of Mus musculus

et al. 1989

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The complex species Mus musculus is widespread in Eurasia and consists of four parapatric genetical entities (subspecies) that have recently radiated. Two of them (M. m. domesticus and M. m. musculus) are known to interact through a narrow zone of hybridisation across which autosomal and mitochondrial exchanges are very limited and Y chromosome exchange is absent. We extend here the study of this group by the genetical analysis of 22 Asian strains of various origins (China, Korea, Japan, Taiwan, Philippines and Indonesia). A survey of protein variation at ten polymorphic loci confirmed that these animals belong to either the subspecies M. m. musculus (northern type in Asia, ranging westwards to Eastern Europe) or to M. m. castaneus (southern Asian type) and revealed a certain degree of intergradation between the two taxa. V chromosome variations were assessed in these strains using a Y specific DNA probe representing part of a small multigene family and also in four M. m. domesticus (the Western European house mouse) strains of various origins and one M. m. bactrianus (from Pakistan). Musculus and castaneus were identically monomorphic for one type of organisation of this Y repeated family, while domesticus and bactrianus were very similar to each other, showing slightly different types of organisation. Introgression of a bactrianus V chromosome into the territory of castaneus was found in Indonesia. The present distribution of the V types among the four subspecies is not phylogenetically concordant with the known distributions of autosomal and mitochondrial variants. The possible role of reticulation to account for this is discussed. The repeated family is organised in a limited number of subfamilies that characterise each of our V types, indicating that a mechanism of concerted evolution underlies its recent evolution in Mus musculus.

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Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome

Cited by 216 publications

References 16 publications

The mosaic structure of variation in the laboratory mouse genome

The mosaic structure of variation in the laboratory mouse genome

mtDNA phylogeny and evolution of laboratory mouse strains

Variations of a Y chromosome repeated sequence across subspecies of Mus musculus

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