Mossy and climbing fibre organization on the anterior lobe of the cerebellum activated by forelimb and hindlimb areas of the sensorimotor cortex

Provini, L.; Redman, S. J.; Strata, Piergiorgio

doi:10.1007/bf00235125

Cited by 111 publications

(52 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, within the rostral dorsal accessory olive (the site of relay for climbing fiber paths terminating in the medial C1 zone), descending and ascending projections overlap heavily (Berkley and Worden, 1978;Bull et al, 1990). We found that complex spikes of single Purkinje cells could be evoked by both SR and CP stimulation, providing unequivocal evidence that descending and ascending paths can converge on the same olivary neurons supplying climbing fibers to the relevant region of cortex, as reported previously (Provini et al, 1968;Miller et al, 1969;Leicht et al, 1973;Allen et al, 1974).…”

Section: Methodological Considerationssupporting

confidence: 84%

“…Regardless of their origin, the COCP and SOCP climbing fiber responses share a common final pathway from the olive to the cerebellar cortex (Provini et al, 1968;Miller et al, 1969;Leicht et al, 1973;Rowe, 1977;Andersson and Nyquist, 1983). The pattern of innervation of olivary neurons by inhibitory and excitatory afferents is random, with no obvious preference for one type of terminal targeting intraglomerular or extraglomerular dendrites .…”

Section: Possible Sites Of Modulationmentioning

confidence: 99%

See 1 more Smart Citation

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Pardoe¹,

Edgley²,

Drew³

et al. 2004

J. Neurosci.

View full text Add to dashboard Cite

The inferior olive climbing fiber projection plays a central role in all major theories of cerebellar function. Therefore, mechanisms that control the ability of climbing fibers to forward information to the cerebellum are of considerable interest. We examined changes in transmission in cerebro-olivocerebellar pathways (COCPs) and spino-olivocerebellar pathways (SOCPs) during locomotion in awake cats (n ϭ 4) using low-intensity electrical stimuli delivered to the contralateral cerebral peduncle or the ipsilateral superficial radial nerve to set up volleys in COCPs and SOCPs, respectively. The responses were recorded as evoked extracellular climbing fiber field potentials within the C1 or C3 zones in the paravermal cerebellar cortex (lobule Va-Vc). At most C1 and C3 zone sites, the largest COCP responses occurred during the stance phase, and the smallest responses occurred during the swing phase of the ipsilateral forelimb step cycle. In marked contrast, SOCP responses recorded at the same sites were usually largest during the swing phase and smallest during the stance phase. Because substantial climbing fiber responses could be evoked in all phases of the step cycle, the results imply that olivary neurons remain excitable throughout, and that the differences between SOCPs and COCPs in their pattern of step-related modulation are unlikely to have arisen solely through inhibition at the level of the inferior olive (e.g., by activity in the inhibitory cerebellar nucleo-olivary pathway). The different patterns of modulation also suggest that climbing fiber signals conveyed by COCPs and SOCPs are likely to affect information processing within the cerebellar cortical C1 and C3 zones at different times during locomotion.

show abstract

Section: Methodological Considerationssupporting

confidence: 84%

Section: Possible Sites Of Modulationmentioning

confidence: 99%

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Pardoe¹,

Edgley²,

Drew³

et al. 2004

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…For stimulation a metal bipolar electrode was subcortically inserted into the first SM cerebral area [13] represents the MF inputs [3,11]. The second wave, with a larger amplitude (around 200-500 /xV), has a latency of about 8-12 msec; it represents the CF inputs [3,11].…”

Section: Pellet Changes In Cerebellar Responses 309mentioning

confidence: 99%

“…The second wave, with a larger amplitude (around 200-500 /xV), has a latency of about 8-12 msec; it represents the CF inputs [3,11]. Both waves have approximately the same threshold during wakefulness (W).…”

Section: Pellet Changes In Cerebellar Responses 309mentioning

confidence: 99%

See 1 more Smart Citation

Changes in Cerebellar Responses evoked by Primary Sensorimotor Cortex Stimulation during Sleep and Wakefulness

Pellet¹,

Dubrocard²,

Harlay³

et al.

Sleep 1972

View full text Add to dashboard Cite

show abstract

Cerebellar premotor output neurons collateralize to innervate the cerebellar cortex

Houck

Person

2015

J of Comparative Neurology

118

View full text Add to dashboard Cite

Motor commands computed by the cerebellum are hypothesized to use corollary discharge, or copies of outgoing commands, to accelerate motor corrections. Identifying sources of corollary discharge, therefore, is critical for testing this hypothesis. Here, we verified that the pathway from the cerebellar nuclei to the cerebellar cortex in mice includes collaterals of cerebellar premotor output neurons, mapped this collateral pathway, and identified its postsynaptic targets. Following bidirectional tracer injections into a distal target of the cerebellar nuclei, the ventrolateral thalamus, we observed retrogradely labeled somata in the cerebellar nuclei and mossy fiber terminals in the cerebellar granule layer, consistent with collateral branching. Corroborating these observations, bidirectional tracer injections into the cerebellar cortex retrogradely labeled somata in the cerebellar nuclei and boutons in the ventrolateral thalamus. To test whether nuclear output neurons projecting to the red nucleus also collateralize to the cerebellar cortex, we used a Cre-dependent viral approach, avoiding potential confounds of direct red nucleus-to-cerebellum projections. Injections of a Cre-dependent GFP-expressing virus into Ntsr1-Cre mice, which express Cre selectively in the cerebellar nuclei, retrogradely labeled somata in the interposed nucleus and putative collateral branches terminating as mossy fibers in the cerebellar cortex. Postsynaptic targets of all labeled mossy fiber terminals were identified using immunohistochemical Golgi cell markers and electron microscopic profiles of granule cells, indicating that the collaterals of nuclear output neurons contact both Golgi and granule cells. These results clarify the organization of a subset of nucleocortical projections which constitute an experimentally accessible corollary discharge pathway within the cerebellum.

show abstract

Mossy and climbing fibre organization on the anterior lobe of the cerebellum activated by forelimb and hindlimb areas of the sensorimotor cortex

Cited by 111 publications

References 18 publications

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Changes in Excitability of Ascending and Descending Inputs to Cerebellar Climbing Fibers during Locomotion

Changes in Cerebellar Responses evoked by Primary Sensorimotor Cortex Stimulation during Sleep and Wakefulness

Cerebellar premotor output neurons collateralize to innervate the cerebellar cortex

Contact Info

Product

Resources

About