Mössbauer study of exogenous iron redistribution between the brain and the liver after administration of 57Fe3O4 ferrofluid in the ventricle of the rat brain

Polikarpov, Dmitry; Gabbasov, R. R.; Черепанов, В. М.; Loginova, N. A.; Loseva, E. V.; Nikitin, Maxim P.; Yurenia, Anton; Panchenko, V. Ya.

doi:10.1016/j.jmmm.2014.10.084

Cited by 10 publications

(2 citation statements)

References 33 publications

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“…It is well-known that the changes caused by biotransformation of iron oxide MNPs are reflected as a transformation of the hyperfine structure. A sign of MNPs biotransformation is the simultaneous appearance of a doublet component in the spectrum, which corresponds to the formation of paramagnetic forms of iron, and a change in the parameters of the sextet components of the spectrum, which corresponds to the degradation of the MNPs crystal lattice [ 26 ]. However, the hyperfine structure of synthesized Co 57 Fe 2 O 4 MNPs spectra remains virtually unchanged even after 6 days of incubation with macrophage cells.…”

Section: Resultsmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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Magnetic nanoparticles (MNPs) are widely considered for cancer treatment, in particular for magnetic hyperthermia (MHT). Thereby, MNPs are still being optimized for lowest possible toxicity on organisms while the magnetic properties are matched for best heating capabilities. In this study, the biocompatibility of 12 nm cobalt ferrite MNPs, functionalized with citrate ions, in different dosages on mice and rats of both sexes was investigated for 30 days after intraperitoneal injection. The animals’ weight, behavior, and blood cells changes, as well as blood biochemical parameters are correlated to histological examination of organs revealing that cobalt ferrite MNPs do not have toxic effects at concentrations close to those used previously for efficient MHT. Moreover, these MNPs demonstrated high specific loss power (SLP) of about 400 W g−1. Importantly the MNPs retained their magnetic properties inside tumor tissue after intratumoral administration for several MHT cycles within three days. Thus, cobalt ferrite MNPs represent a perspective platform for tumor therapy by MHT due to their ability to provide effective heating without exerting a toxic effect on the organism. This opens up new avenues for smaller MNPs sizes while their heating efficiency is maintained.

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Section: Resultsmentioning

confidence: 99%

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

et al. 2021

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“…Точный анализ мёссбауэровских спектров (МС) очень затруднен, если размеры частиц менее 10 nm потому, что при таких размерах НЧ-эффект суперпарамагнитной релаксации приводит к уширению и перекрытию зеемановских линий в МС, что делает сверхтонкую структуру спектров неразрешенной и количественный анализ МС чрезвычайно сложным [46]. Однако при размерах НЧ более 10 nm, когда отсутствуют релаксационные эффекты, уникальная чувствительность эффекта Мёссбауэра к локальному окружению атомов Fe в кристаллической решетке, позволяет мёссбауэровской спектроскопии уверенно различить фазы оксидов и гидроксидов железа [47,48], что недоступно другим методикам.…”

Section: Introductionunclassified

Мёссбауэровские исследования состава и магнитной структуры нанокомпозитов Fe-=SUB=-3-=/SUB=-O-=SUB=-4-=/SUB=-/γFe-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=- типа ядро--оболочка при температура 300 и 80 K (Часть I)

Kamzin¹,

Obaidat

Валлиулин³

et al. 2020

Физика Твердого Тела

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The results of Mössbauer studies of the magnetic structure and composition of Fe3O4 / γ-Fe2O3 nanoparticles at temperatures of 300 and 80 K are presented. It was found that particles Fe3O4 /γ-Fe2O3 is a core / shell nanocomposite (NC) in which magnetite (Fe3O4) is a coated by shell of maghemite (γ-Fe2O3). It was shown that the thickness of the maghemite (γ-Fe2O3) shell depends on the synthesis technology. It was found that, in the Fe3O4 /γ-Fe2O3 NC, on the surface of the maghemite (γ-Fe2O3) shell, a layer whose magnetic structure differs from the structure of the inner part of the shell (γ-Fe2O3). An intermediate layer is formed between the core and the shell in a spin-glass state. The obtained data on the structure of core / shell nanocomposites open up prospects for explaining the properties of such particles, which are of great interest for applications in various fields, including biomedicine.

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Mössbauer and X-ray study of biodegradation of 57Fe3 O 4 magnetic nanoparticles in rat brain

et al. 2016

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Mössbauer study of exogenous iron redistribution between the brain and the liver after administration of 57Fe3O4 ferrofluid in the ventricle of the rat brain

Cited by 10 publications

References 33 publications

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Cobalt Ferrite Nanoparticles for Tumor Therapy: Effective Heating versus Possible Toxicity

Mössbauer and X-ray study of biodegradation of 57Fe3 O 4 magnetic nanoparticles in rat brain

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