Mosquito larvae control by photodynamic inactivation of their intestinal flora – a proof of principal study on Chaoborus sp.†

Preuß, Annegret; Pfitzner, Michael; Röder, Beate

doi:10.1039/c9pp00156e

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…When the PSI curcumin is ingested by Ae. aegypti larvae, for example, it accumulates throughout the gut and permeates into the hemocoel, 39 but when the PSIs TPPS, TMPyP and mTHPC (porphyrin derivatives) are ingested by Chaoborus crystallinus larvae, they all remain confined to the larval gut 24 . Here, we observed that MB – which is similar in size to curcumin – accumulates in the gut, gastric caeca and hemocoel of both Ae.…”

Section: Discussionmentioning

confidence: 59%

“…The rapid photodegradation of PSIs is an ecological advantage for these broad‐spectrum insecticides. Due to their photoactivation mechanism, PSIs are toxic to small, translucent aquatic insects 20–26 . However, PSIs are non‐toxic to translucent zebrafish even after light irradiation 27 .…”

Section: Introductionmentioning

confidence: 99%

“…Under laboratory conditions, the PSIs curcumin, RB, hematoporphyrin and eosin‐MB are toxic to Aedes aegypti larvae, and RB is toxic against Anopheles gambiae and Culex quinquefasciatus 20–23 . PSIs are also toxic to Chaoboridae, which is a dipteran family closely related to mosquitoes 24–26 . However, significant differences in the experimental design of these studies make it difficult to determine which PSIs are most efficient, or how PSI toxicity varies between species.…”

Section: Introductionmentioning

confidence: 99%

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Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

Meier,

Hillyer

2023

Pest Management Science

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BACKGROUNDInsecticides are critical for controlling mosquito populations and mitigating the spread of vector–borne disease, but their overuse has selected for resistant populations. A promising alternative to classical chemical insecticides is photosensitive molecules—here called photosensitive insecticides or PSIs—that when ingested and activated by light, generate broadly toxic reactive oxygen species. This mechanism of indiscriminate oxidative damage decreases the likelihood that target site modification‐based resistance evolves. Here, we tested whether the PSIs, methylene blue (MB) and rose bengal (RB), are viable insecticides across the mosquito lineage.RESULTSMB and RB are phototoxic to both Ae. aegypti and An. gambiae at micromolar concentrations, with greatest toxicity when larvae are incubated in the dark with the PSIs for 2 hr prior to photoactivation. MB is ten times more toxic than RB, and microscopy‐based imaging suggests that this is because ingested MB escapes the larval gut and disperses throughout the hemocoel whereas RB remains confined to the gut. Adding food to the PSI‐containing water has a bidirectional, concentration‐dependent effect on PSI toxicity; toxicity increases at high concentrations but decreases at low concentrations. Finally, adding sand to the water increases the phototoxicity of RB to Aedes aegypti.CONCLUSIONMB and RB are larvicidal via a light activated mechanism, and therefore, should be further investigated as an option for mosquito control.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

Meier,

Hillyer

2023

Pest Management Science

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“…A study by Preuß et al . (587) investigated the use of temoporfin, a cationic and anionic photosensitizer for Mosquito larvae control. Using Chaoborus sp.…”

Section: Other Applicationsmentioning

confidence: 99%

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade^†^‡

Wiehe

Senge

2022

Photochem & Photobiology

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This review follows the research, development and clinical applications of the photosensitizer 5,10,15,20-tetra(mhydroxyphenyl)chlorin (mTHPC, temoporfin) in photodynamic (cancer) therapy (PDT) and other medical applications. Temoporfin is the active substance in the medicinal product Foscanâ authorized in the EU for the palliative treatment of head and neck cancer. Chemistry, biochemistry and pharmacology, as well as clinical and other applications of temoporfin are addressed, including the extensive work that has been done on formulation development including liposomal formulations. The literature has been covered from 2009 to early 2022, thereby connecting it to the previous extensive review on this photosensitizer published in this journal [Senge, M. O. and J. C. Brandt (2011) Photochem. Photobiol. 87, 1240-1296] which followed its way from initial development to approval and clinical application.

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“…To test for biological function, i.e., photochemical defense, a photoinsecticidal assay utilizing Chaoboridae larvae (Chaoborus crystallinus) was performed according to Preuß and colleagues [39]. In brief, ten larvae were treated with a methanolic extract of C. sanguineus var.…”

Section: Photolarvicidal Activitymentioning

confidence: 99%

Photochemical defense as trait of fungi from Cortinarius subgenus Dermocybe

Hannecker

Huymann

Hammerle

et al. 2022

Photochem Photobiol Sci

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The photobiological activity of ten colorful species belonging to subgenus Dermocybe of the basidiomycete genus Cortinarius was investigated. Extracts of all species produced singlet oxygen and are thus photoactive. Pigment analysis was performed and showed similarities of the anthraquinone pigments across the species in dependency to their respective pigmentation types. Detailed content analysis of the pigments in the whole agaricoid fruiting body compared to the three different tissue types (pileus, stipe, and lamellae) revealed that the pigments emodin, dermocybin, and dermorubin, as well as their respective glycosides, are enhanced in the gills. In an independent experiment, the gills were shown to be the most photoactive tissues of the fruiting body. Photobiological experiments with invertebrates (i.e., glassworm Chaoborus crystallinus) proved a phototoxic effect of the methanolic extract of the red blood webcap (Cortinarius sanguineus var. aurantiovaginatus). This work adds further evidence to a common photobiological trait in Cortinarius subgenus Dermocybe and underpins the possibility of a photochemical defense mechanism in fungi. Graphical abstract

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Mosquito larvae control by photodynamic inactivation of their intestinal flora – a proof of principal study on Chaoborus sp.†

Abstract: The aim of this study is to investigate the potential of photodynamic agents to combat mosquito larvae, the carriers of dangerous pathogens around the world. All photosensitizers tested were observed in the digestive tract of the larvae.

Cited by 10 publications

References 41 publications

Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade^†^‡

Photochemical defense as trait of fungi from Cortinarius subgenus Dermocybe

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Mosquito larvae control by photodynamic inactivation of their intestinal flora – a proof of principal study on Chaoborus sp.†

Abstract: The aim of this study is to investigate the potential of photodynamic agents to combat mosquito larvae, the carriers of dangerous pathogens around the world. All photosensitizers tested were observed in the digestive tract of the larvae.

Cited by 10 publications

References 41 publications

Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

Larvicidal activity of the photosensitive insecticides, methylene blue and rose bengal, in Aedes aegypti and Anopheles gambiae mosquitoes

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade†‡

Photochemical defense as trait of fungi from Cortinarius subgenus Dermocybe

Contact Info

Product

Resources

About

The Photosensitizer Temoporfin (mTHPC) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade^†^‡