Moshen granule ameliorates membranous nephropathy by blocking intrarenal renin-angiotensin system signalling via the Wnt1/β-catenin pathway

Wang, Yanni; Miao, Hua; Hua, Meng-Ru; Yang, Junzheng; Pei, Ming; Yu, Hangxing; Wei, Lidong; Zou, Liang; Zhang, Yamei; Cao, Gang; Zhao, Ying-Yong

doi:10.1016/j.phymed.2023.154763

Cited by 16 publications

(6 citation statements)

References 21 publications

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“…Many publications have demonstrated that natural products have beneficial effects on renal fibrosis and that natural products are a promising source of new medicines ( Newman and Cragg, 2020 ; Wang et al, 2023a ). A growing body of evidence has revealed the molecular mechanisms of natural products, and numerous natural products suppress renal fibrosis though the NF-ƙB pathway ( Chen et al, 2018 ).…”

Section: Therapeutic Strategies Targeting the Nf-ƙb Signaling Pathway...mentioning

confidence: 99%

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis

Ren,

Wang,

Zou

et al. 2024

Front. Pharmacol.

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Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress and inflammation play central roles in progressive renal fibrosis. Oxidative stress and inflammation are closely linked and form a vicious cycle in which oxidative stress induces inflammation through various molecular mechanisms. Ample evidence has indicated that a hyperactive nuclear factor kappa B (NF-ƙB) signaling pathway plays a pivotal role in renal fibrosis. Hyperactive NF-ƙB causes the activation and recruitment of immune cells. Inflammation, in turn, triggers oxidative stress through the production of reactive oxygen species and nitrogen species by activating leukocytes and resident cells. These events mediate organ injury through apoptosis, necrosis, and fibrosis. Therefore, developing a strategy to target the NF-ƙB signaling pathway is important for the effective treatment of renal fibrosis. This Review summarizes the effect of the NF-ƙB signaling pathway on renal fibrosis in the context of AKI and CKD (immunoglobulin A nephropathy, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy, and kidney transplantation). Therapies targeting the NF-ƙB signaling pathway, including natural products, are also discussed. In addition, NF-ƙB-dependent non-coding RNAs are involved in renal inflammation and fibrosis and are crucial targets in the development of effective treatments for kidney disease. This Review provides a clear pathophysiological rationale and specific concept-driven therapeutic strategy for the treatment of renal fibrosis by targeting the NF-ƙB signaling pathway.

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Section: Therapeutic Strategies Targeting the Nf-ƙb Signaling Pathway...mentioning

confidence: 99%

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis

Ren,

Wang,

Zou

et al. 2024

Front. Pharmacol.

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“…Sixteen Sprague-Dawley male rats (RRID:RGD_70508) were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China), with an initial body weight of 180-220 g. Healthy rats were randomly divided into two groups (n = 8): controls and CBSA-induced MN. The MN model was established with CBSA as reported in our previous publication (Wang, Miao, et al, 2023). Moshen granule (MSG) is a renoprotective traditional Chinese medicine, and its composition has been reported in our previous publication (Wang, Miao, et al, 2023).…”

Section: Animal Experimental Designmentioning

confidence: 99%

“…The MN model was established with CBSA as reported in our previous publication (Wang, Miao, et al, 2023). Moshen granule (MSG) is a renoprotective traditional Chinese medicine, and its composition has been reported in our previous publication (Wang, Miao, et al, 2023). An additional MN group was administered MSG (3.70 gÁkg À1 , dissolved in water) by gastric irrigation for four continuous weeks.…”

Section: Animal Experimental Designmentioning

confidence: 99%

Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites

Miao,

Wang,

et al. 2023

British J Pharmacology

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Background and PurposeMembranous nephropathy (MN) is an immune‐mediated glomerular disease among adults. Antibodies and antigens bonding mechanisms have been largely clarified, but few subepithelium immune complex deposition‐mediated underlying downstream molecular mechanisms are currently known. Increasing evidence has suggested that gut microbiota contributed to MN pathogenesis.Experimental ApproachIn this study, we identified alteration of faecal gut microbiota and serum metabolites that mediated aryl hydrocarbon receptor (AhR) mechanism in cationic bovine serum albumin (CBSA)‐induced MN rats and patients with IMN.Key ResultsWe found that impaired renal function correlated with relative abundances of reduced faecal probiotics Lactobacillus and Bifidobacterium and serum levels of altered tryptophan‐produced indole derivatives (TPID) in MN rats. Further results showed that reduced relative abundances of five probiotics including Lactobacillus johnsonii, Lactobacillus murinus, Lactobacillus vaginalis, Lactobacillus reuteri and Bifidobacterium animalis positively correlated with levels of decreased indole‐3‐pyruvic acid, indole‐3‐aldehyde and tryptamine, and negatively correlated with levels of increased indole‐3‐lactic acid and indole‐3‐acetic acid in serum of MN rats. Altered five probiotics and five TPID were also observed in patients with IMN. Further studies showed that MN rats exhibited a significant increase in intrarenal mRNA expressions of AhR and its target genes CYP1A1, CYP1A2 and CYP1B1, which was accompanied by protein expressions of downregulated cytoplasm AhR while upregulated nuclei AhR in MN rats and IMN patients.Conclusion and Implicationsctivation of intrarenal AhR signaling pathway might be mediated by five TPID. These data suggest that gut microbiota could influence MN through TPID engaging host receptors.

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“…Animal studies have substantiated the efficacy of these formulations in ameliorating proteinuria and increasing serum albumin (ALB) [ 7 , 8 ]. TCM interventions potentially exert their influence on IMN through multifaceted mechanisms, including anti-inflammatory and immunosuppressive effects and improving podocyte injury [ 9 , 10 ]. Advancements in theoretical and clinical studies on the use of TCM for the treatment of IMN have demonstrated the efficacy of TCM.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine for idiopathic membranous nephropathy: A systematic review and meta-analysis

Shan,

Guan,

et al. 2024

Heliyon

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Moshen granule ameliorates membranous nephropathy by blocking intrarenal renin-angiotensin system signalling via the Wnt1/β-catenin pathway

Cited by 16 publications

References 21 publications

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis

The nuclear factor kappa B signaling pathway is a master regulator of renal fibrosis

Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites

Traditional Chinese medicine for idiopathic membranous nephropathy: A systematic review and meta-analysis

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