MOSFET dosimetry mission inside the ISS as part of the Matroshka-R experiment

Hallil, A; Brown, Michael E.; Akatov, Yu.A.; Arkhangelsky, V.; Chernykh, I. V.; Mitrikas, V. G.; Petrov, V. M.; Shurshakov, Vyacheslav; Tomi, Leena; Kartsev, Ivan; Lyagushin, V. I.

doi:10.1093/rpd/ncp265

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…Experiments and simulations have been conducted to explore the space radiation hazards that astronauts are exposed to. Experiments have been performed to measure the radiation doses received by humanlike phantoms including a phantom head (1989)(1990)), [1] a spherical phantom ), [2] the phantom torso 'Fred' (1998,2001), [3][4][5] and the MATROSHKA series of mannequins (MATROSHKA-R 2004-2005, [6][7][8] MATROSHKA-1 2004-2005, [9] MATROSHKA-2A 2005, [10] MATROSHKA-2B 2007, [10] and MATROSHKA-KIBO 2010-2011 [11] ) on board spacecraft. These human-like phantoms were well instrumented with radiation detectors in their vital organs so as to measure the biological radiation parameters, including the dose, the equivalent dose, the effective dose, etc.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo calculation of the exposure of Chinese female astronauts to earth’s trapped radiation on board the Chinese Space Station

Guo¹,

Yan

Fang

et al. 2023

Chinese Phys. B

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With the development of China's crewed space mission, the space radiation risk for astronauts is increasingly prominent. The aim of this paper is to simulate the radiation doses in a Chinese female voxel phantom onboard the China Space Station (CSS) by Monte Carlo N Particle (MCNP) simulation. The absorbed dose, equivalent dose, and effective dose in voxel phantom and in its’ critical organs with different shielding of Tianhe core module are discussed. Then, the risk of space-radiation exposure is assessed by comparing the doses with the current risk limits at China (skin dose limit at short term low-earth-orbit missions) and NASA (NCRP Report No. 98) for female astronaut. The results obtained can be used to guide and optimize the radiation protection in the manned space missions.

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Section: Introductionmentioning

confidence: 99%

Monte Carlo calculation of the exposure of Chinese female astronauts to earth’s trapped radiation on board the Chinese Space Station

Guo¹,

Yan

Fang

et al. 2023

Chinese Phys. B

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“…Data obtained from these animals were compared with that obtained from control animals, which were raised in 1 g conditions on Earth. Although the results of these experiments can be informative, other factors in the space environment than microgravity could affect the results, such as lack of convection, microbial environment [ 7 , 8 ], cosmic radiation [ 9 , 10 ], stressful conditions induced by launch and landing, and maybe some other factors likely still not suspected.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments

et al. 2015

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To elucidate the pure impact of microgravity on small mammals despite uncontrolled factors that exist in the International Space Station, it is necessary to construct a 1 g environment in space. The Japan Aerospace Exploration Agency has developed a novel mouse habitat cage unit that can be installed in the Cell Biology Experiment Facility in the Kibo module of the International Space Station. The Cell Biology Experiment Facility has a short-arm centrifuge to produce artificial 1 g gravity in space for mouse experiments. However, the gravitational gradient formed inside the rearing cage is larger when the radius of gyration is shorter; this may have some impact on mice. Accordingly, biological responses to hypergravity induced by a short-arm centrifuge were examined and compared with those induced by a long-arm centrifuge. Hypergravity induced a significant Fos expression in the central nervous system, a suppression of body mass growth, an acute and transient reduction in food intake, and impaired vestibulomotor coordination. There was no difference in these responses between mice raised in a short-arm centrifuge and those in a long-arm centrifuge. These results demonstrate the feasibility of using a short-arm centrifuge for mouse experiments.

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Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice

et al. 2017

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The Japan Aerospace Exploration Agency recently performed a mouse experiment in the International Space Station in which mice were raised for 35 days, retrieved using the Dragon spacecraft, and then harvested for analysis 2 days after splashdown. However, the impact of the retrieval procedure, which exposed mice to 5-10 g for 2 min during atmospheric reentry and splashdown, was unknown. Therefore, the purpose of this study was to examine the impact of a 10 g load for 2 min (using a gondola-type centrifuge with a 1.5-m arm installed at Gifu University) on conscious mice. Plasma corticosterone increased at 30 min after load application and recovered at 90 min. Significant Fos expression was observed in the vestibular nuclei (VeN), paraventricular hypothalamic nucleus (PVN), and central nucleus of the amygdala (CeA). Rearing behavior and food intake were suppressed. Mice with vestibular lesions demonstrated increased corticosterone and Fos expression in the PVN, but neither suppression of food intake and rearing behavior nor increased Fos expression in the VeN and CeA. These results suggest that the simulated gravity load induced a transient stress response, hypoactivity, and a vestibular-mediated suppression of food intake.

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MOSFET dosimetry mission inside the ISS as part of the Matroshka-R experiment

Cited by 12 publications

References 13 publications

Monte Carlo calculation of the exposure of Chinese female astronauts to earth’s trapped radiation on board the Chinese Space Station

Monte Carlo calculation of the exposure of Chinese female astronauts to earth’s trapped radiation on board the Chinese Space Station

Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments

Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice

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