MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

Bräuer-Krisch, Elke; Bravin, A.; Lerch, Michael L. F; Rosenfeld, Anatoly B.; Stĕpánek, J.; Michiel, Marco Di; Laissue, Jean A.

doi:10.1118/1.1562169

Cited by 96 publications

(79 citation statements)

References 22 publications

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“…MOSFETs are reported to have been used in the context of standard external beam radiation therapy, 1 intensity modulated radiation therapy, 2 in vivo dosimetry, [3][4][5] image guided radiotherapy, 6 microbeam radiotherapy, 7 and diagnostic radiology. 8 Such measurements are either carried out at energies well above 300 keV ͑where the response remains fairly constant͒ or under nonvarying photon spectrum conditions.…”

Section: Introductionmentioning

confidence: 99%

Absolute depth-dose-rate measurements for an Ir192 HDR brachytherapy source in water using MOSFET detectors

et al. 2006

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This article was originally published as Zilio. VO, Joneja, OP, Popowski, Y et al, Absolute depth-dose-rate measurements for an 192Ir HDR brachytherapy source in water using MOSFET detectors, Medical Physics, 33(6) Reported MOSFET measurements concern mostly external radiotherapy and in vivo dosimetry. In this paper, we apply the technique for absolute dosimetry in the context of HDR brachytherapy using an 192 Ir source. Measured radial dose rate distributions in water for different planes perpendicular to the source axis are presented and special attention is paid to the calibration of the R and K type detectors, and to the determination of appropriate correction factors for the sensitivity variation with the increase of the threshold voltage and the energy dependence. The experimental results are compared with Monte Carlo simulated dose rate distributions. The experimental results show a good agreement with the Monte Carlo simulations: the discrepancy between experimental and Monte Carlo results being within 5% for 82% of the points and within 10% for 95% of the points. Moreover, all points except two are found to lie within the experimental uncertainties, confirming thereby the quality of the results obtained.

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Section: Introductionmentioning

confidence: 99%

Absolute depth-dose-rate measurements for an Ir192 HDR brachytherapy source in water using MOSFET detectors

et al. 2006

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“…The interpretation of the effects of MRT on biological tissue is complicated by difficulties in accurately measuring the absorbed dose deposited in tissue by MRT. Physical dosimetry associated with MRT is more complex than that for conventional broad-beam (BB) radiotherapy because there are different components to an MRT dose profile [9][10][11][12]. These components include the in-beam or \peak" dose, the valley dose (between adjacent microbeams) and the integrated dose.…”

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confidence: 99%

Biodosimetric quantification of short-term synchrotron microbeam versus broad-beam radiation damage to mouse skin using a dermatopathological scoring system

Priyadarshika

Crosbie²,

Kumar³

et al. 2011

BJR

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Objectives: Microbeam radiotherapy (MRT) with wafers of microscopically narrow, synchrotron generated X-rays is being used for pre-clinical cancer trials in animal models. It has been shown that high dose MRT can be effective at destroying tumours in animal models, while causing unexpectedly little damage to normal tissue. The aim of this study was to use a dermatopathological scoring system to quantify and compare the acute biological response of normal mouse skin with microplanar and broad-beam (BB) radiation as a basis for biological dosimetry. Method: The skin flaps of three groups of mice were irradiated with high entrance doses (200 Gy, 400 Gy and 800 Gy) of MRT and BB and low dose BB (11 Gy, 22 Gy and 44 Gy). The mice were culled at different time-points post-irradiation. Skin sections were evaluated histologically using the following parameters: epidermal cell death, nuclear enlargement, spongiosis, hair follicle damage and dermal inflammation. The fields of irradiation were identified by cH2AX-positive immunostaining. Results: The acute radiation damage in skin from high dose MRT was significantly lower than from high dose BB and, importantly, similar to low dose BB. Conclusion: The integrated MRT dose was more relevant than the peak or valley dose when comparing with BB fields. In MRT-treated skin, the apoptotic cells of epidermis and hair follicles were not confined to the microbeam paths.

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“…The Centre has obtained extensive experience with MOSFET dosimetry applications in a range of different radiation oncology modalities including medical LINACs [51][52][53][54][55], brachytherapy [56,57], microbeam radiation therapy [46,[58][59][60][61] and neutron therapy [62][63][64]. A summary of the advantages and challenges of MOSFET dosimetry in a range of radiation therapy modalities has been presented in [2].…”

Section: Mosfet Dosimetrymentioning

confidence: 99%

Advanced Semiconductor Dosimetry in Radiation Therapy

Rosenfeld

2011

AIP Conference Proceedings

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Modern radiation therapy is very conformal, resulting in a complexity of delivery that leads to many small radiation fields with steep dose gradients, increasing error probability. Quality assurance in delivery of such radiation fields is paramount and requires real time and high spatial resolution dosimetry. Semiconductor radiation detectors due to their small size, ability to operate in passive and active modes and easy real time multichannel readout satisfy many aspects of in vivo and in a phantom quality assurance in modern radiation therapy. Update on the recent developments and improvements in semiconductor radiation detectors and their application for quality assurance in radiation therapy, based mostly on the developments at the Centre for Medical Radiation Physics (CMRP), University of Wollongong, is presented. Abstract. Modern radiation therapy is very conformal, resulting in a complexity of delivery that leads to many small radiation fields with steep dose gradients, increasing error probability. Quality assurance in delivery of such radiation fields is paramount and requires real time and high spatial resolution dosimetry. Semiconductor radiation detectors due to their small size, ability to operate in passive and active modes and easy real time multichannel readout satisfy many aspects of in vivo and in a phantom quality assurance in modern radiation therapy. Update on the recent developments and improvements in semiconductor radiation detectors and their application for quality assurance in radiation therapy, based mostly on the developments at the Centre for Medical Radiation Physics (CMRP), University of Wollongong, is presented.

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MOSFET dosimetry for microbeam radiation therapy at the European Synchrotron Radiation Facility

Cited by 96 publications

References 22 publications

Absolute depth-dose-rate measurements for an Ir192 HDR brachytherapy source in water using MOSFET detectors

Absolute depth-dose-rate measurements for an Ir192 HDR brachytherapy source in water using MOSFET detectors

Biodosimetric quantification of short-term synchrotron microbeam versus broad-beam radiation damage to mouse skin using a dermatopathological scoring system

Advanced Semiconductor Dosimetry in Radiation Therapy

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