Mosaic properties of midget and parasol ganglion cells in the marmoset retina

Szmajda, Brett A.; Martin, Paul R.

doi:10.1017/s0952523805224021

Cited by 29 publications

(45 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such dendrites were found in midget ganglion cells of both phenotypes. Consistent with previous studies (Dacey, 1993;Yamada et al, 1996;Szmajda et al, 2005), the dendritic trees of neighboring midget ganglion cells show little or no overlap (see Fig. 4C).…”

Section: Midget Ganglion Cellssupporting

confidence: 79%

“…The size and shape of the dendritic trees of the ganglion cells in these images are comparable. The morphology of retrogradely labeled midget ganglion cells shown here agrees with previous descriptions Szmajda et al, 2005). Midget ganglion cells have a single thick primary dendrite and the soma is usually located near the edge of the dendritic tree.…”

Section: Midget Ganglion Cellssupporting

confidence: 79%

“…However, similarly shaped fields have been seen in the retina of dichromatic Cebus monkeys (Yamada et al, 1996). In both dichromatic and trichromatic marmosets, the dendritic field perimeter of midget ganglion cells is smooth but mildly elliptical Szmajda et al, 2005). A direct analysis of the connectivity of the two cell types in any of these primate species, however, is still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Retrogradely labeled ganglion cells were photofilled as described in detail previously Szmajda et al, 2005). Briefly, the eyes were enucleated, the cornea, lens, and vitreous were removed and the posterior eyecup was immersed in carboxygenated Ames medium (Sigma, St. Louis, MO).…”

Section: Retrograde Labeling Of Retinal Ganglion Cells In Marmosetsmentioning

confidence: 99%

“…Dye injections were performed as described previously (Szmajda et al, 2005;Jusuf et al, 2006). Briefly, animals were anesthetized with isofluorane (Forthane; Abbott, Sydney, Australia; ICI, 1-2%) and intramuscular ketamine (30 mg/kg) and xylazine hydrochloride (Rompun; Bayer Animal Health Australia, Pymble, New South Wales, Australia; 2-4 g/kg).…”

Section: Retrograde Labeling Of Retinal Ganglion Cells In Marmosetsmentioning

confidence: 99%

See 4 more Smart Citations

Random Wiring in the Midget Pathway of Primate Retina

Jusuf¹,

Martin²

2006

J. Neurosci.

View full text Add to dashboard Cite

The present study addresses the questions of how topographically organized neuronal populations are connected, and whether there is anatomical evidence for color-selective wiring in retinal pathways for red-green color vision. The connectivity of OFF midget bipolar and OFF midget ganglion cells was studied in the peripheral retina of dichromatic ("red-green color blind") and trichromatic ("color normal") marmosets (Callithrix jacchus). Midget bipolar cells were identified immunohistochemically. Midget ganglion cells were retrogradely labeled from the lateral geniculate nucleus and photofilled. Comparable results were obtained from all retinas studied. Between 3 and 16 bipolar terminals converge onto each ganglion cell. Nearly all bipolar terminals investigated show regions of colocalization (areas of presumed synaptic contacts) with ganglion cell dendrites. This contact area makes up ϳ14% of the axon surface area for a typical midget bipolar cell. The output from individual midget bipolar axons is often shared between midget ganglion cells so that, on average, Ͻ70% of the axon terminal area of a midget bipolar cell shows overlap with the dendritic field of a given midget ganglion cell. We conclude that there is no morphological evidence of red-green color selectivity in the connections between midget bipolar and midget ganglion cell mosaics. Furthermore, the results suggest that convergence is based on local interactions between axons and dendrites rather than cell-by-cell recognition between members of each mosaic.

show abstract

Section: Midget Ganglion Cellssupporting

confidence: 79%

Section: Midget Ganglion Cellssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Retrograde Labeling Of Retinal Ganglion Cells In Marmosetsmentioning

confidence: 99%

Section: Retrograde Labeling Of Retinal Ganglion Cells In Marmosetsmentioning

confidence: 99%

See 3 more Smart Citations

Random Wiring in the Midget Pathway of Primate Retina

Jusuf¹,

Martin²

2006

J. Neurosci.

View full text Add to dashboard Cite

show abstract

Synaptic connectivity in the midget‐parvocellular pathway of primate central retina

Jusuf

Martin

Grünert

2005

J of Comparative Neurology

Self Cite

View full text Add to dashboard Cite

The synaptic connectivity of OFF midget bipolar cells was investigated in the central retina of two primate species, the New World common marmoset monkey, Callithrix jacchus, and the Old World macaque monkey, Macaca fascicularis. In marmosets, dichromatic and trichromatic animals were compared. Bipolar output synapses were identified with antibodies against ribbon proteins (kinesin, C-terminal binding protein 2) or with an antiserum that recognizes postsynaptic glutamate receptor clusters (GluR4). The midget bipolar cells were identified immunocytochemically with antibodies to CD15 (marmoset) or an antiserum to recoverin (macaque). In marmosets, midget ganglion cells were retrogradely labeled from the parvocellular layers of the dorsal lateral geniculate nucleus. Consistent with previous studies of Old World primates, in marmoset, midget bipolar cells contacted midget ganglion cells at a ratio of 1:1. The number of output synapses made by OFF midget bipolar cells was quantified for 104 cells in two dichromatic marmosets, 108 cells in one trichromatic marmoset, and 118 cells in one macaque. The number of output synapses was comparable for all animals, ranging from 10-71 in the dichromatic marmoset (average 29.7 +/- 12.4 SD), 12-86 in the trichromatic marmoset (average 28.6 +/- 11.7 SD) and 9-48 in the macaque (average 26.5 +/- 9.3 SD) per axon terminal. In all animals the number of output synapses per axon terminal showed a unimodal distribution. Our results suggest that the midget circuitry is comparable in dichromatic and trichromatic animals.

show abstract

Retinal ganglion cell inputs to the koniocellular pathway

Szmajda

Grünert

Martin

2008

J of Comparative Neurology

Self Cite

133

View full text Add to dashboard Cite

To understand the transmission of sensory signals in visual pathways we studied the morphology and central projection of ganglion cell populations in marmoset monkeys. Retinal ganglion cells were labeled by photofilling following injections of retrograde tracer in the lateral geniculate nucleus (LGN), or by intracellular injection with neurobiotin. Ganglion cell morphology was analyzed using hierarchical cluster analysis. In addition to midget and parasol ganglion cells, this method distinguished three main clusters of wide-field cells that correspond to small bistratified, sparse, and broad thorny cells identified previously. The small bistratified and sparse cells occupy neighboring positions on the hierarchical (linkage distance) tree. These cell types are presumed to carry signals originating in short-wavelength sensitive (S or "blue") cones in the retina. The linkage distance from these putative S-cone pathway ganglion cells to other wide-field cells is similar to the linkage distance from midget cells to parasol cells, suggesting that S-cone cells form a distinct functional subgroup of ganglion cells. Small bistratified cells and large sparse cells were the most commonly labeled wide-field cells following LGN injections in koniocellular layer K3. This is consistent with physiological evidence that the role of this layer includes transmission of S-cone signals to the visual cortex. Other wide-field cell types were also labeled following injections including K3, and other koniocellular LGN layers; these cell types may correspond to "non-blue koniocellular" receptive fields recorded in physiological studies.

show abstract

Mosaic properties of midget and parasol ganglion cells in the marmoset retina

Cited by 29 publications

References 53 publications

Random Wiring in the Midget Pathway of Primate Retina

Random Wiring in the Midget Pathway of Primate Retina

Synaptic connectivity in the midget‐parvocellular pathway of primate central retina

Retinal ganglion cell inputs to the koniocellular pathway

Contact Info

Product

Resources

About