Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways

Xu, Pingkang; Chen, Qimin; Chen, Xiaoman; Qi, Hao; Yang, Yuyan; Li, Weiqi; Yang, Xin; Gunawan, Amelia; Chen, Shuoyu; Zhang, Huimin; Shen, Han‐Ming; Huang, Dejian; Kennedy, Brian K.; Xu, Li; Wu, Ziyun

doi:10.1007/s11357-022-00693-2

Cited by 9 publications

(12 citation statements)

References 37 publications

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“…[64,65] Caffeine-induced lifespan extension is abolished in daf-2, age-1, and daf-16 mutants, which are involved in the insulin/IGF-1-like pathway, and in akt-1 and akt-2 mutants, which are involved in the insulin/IGF-1-like and TOR pathways. [65][66][67][68] In addition, RNA interference (RNAi) of daf-16 and of cbp-1, which encodes an acetyltransferase that acetylates DAF-16 and inhibits nuclear translocation. [69] prevents lifespan extension by caffeine.…”

Section: Caffeinementioning

confidence: 99%

“…[68] The regulation of p70S6K1 phosphorylation and the induction of autophagy are involved in the regulation of aging. [68] 2.6. Gentirigeoside B Gentirigeoside B from Gentiana rigescens Franch increases RLS and CLS in S. cerevisiae.…”

Section: Morusin Mulberrin and Cudraflavone Bmentioning

confidence: 99%

“…[ 68 ] CLS extension by morusin and mulberrin in budding yeast was significantly reduced in calorie‐restricted medium (glucose concentration was reduced from 2% to 0.5%), suggesting that these CLS extensions are involved in inhibiting nutrient‐sensing pathways. [ 68 ] In addition, mulberrin‐induced CLS extension was not observed in strains with deletions of Tor1 kinase of TORC1 or several factors downstream of TORC1, including Sch9, suggesting that the mulberrin‐induced CLS extension is dependent on the TORC1 pathway. [ 68 ] udraflavone B, an analog of morusin and mulberrin, reportedly extends CLS of S. cerevisiae in a TORC1 pathway‐dependent manner.…”

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

“…[ 68 ] In addition, mulberrin‐induced CLS extension was not observed in strains with deletions of Tor1 kinase of TORC1 or several factors downstream of TORC1, including Sch9, suggesting that the mulberrin‐induced CLS extension is dependent on the TORC1 pathway. [ 68 ] udraflavone B, an analog of morusin and mulberrin, reportedly extends CLS of S. cerevisiae in a TORC1 pathway‐dependent manner. [ 68 ] However, because morusin extends CLS even in Δ sch9 cells, not all analogs of morusin, mulberrin, or cudraflavon B may cause CLS extension through the same mechanism.…”

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

“…[ 68 ] udraflavone B, an analog of morusin and mulberrin, reportedly extends CLS of S. cerevisiae in a TORC1 pathway‐dependent manner. [ 68 ] However, because morusin extends CLS even in Δ sch9 cells, not all analogs of morusin, mulberrin, or cudraflavon B may cause CLS extension through the same mechanism.…”

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

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Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Yeast is an excellent model organism for research for regulating aging and lifespan, and the studies have made many contributions to date, including identifying various factors and signaling pathways related to aging and lifespan. More than 20 years have passed since molecular biological perspectives are adopted in this research field, and intracellular factors and signal pathways that control aging and lifespan have evolutionarily conserved from yeast to mammals. Furthermore, these findings have been applied to control the aging and lifespan of various model organisms by adjustment of the nutritional environment, genetic manipulation, and drug treatment using low‐molecular weight compounds. Among these, drug treatment is easier than the other methods, and research into drugs that regulate aging and lifespan is consequently expected to become more active. Chronological lifespan, a definition of yeast lifespan, refers to the survival period of a cell population under nondividing conditions. Herein, low‐molecular weight compounds are summarized that extend the chronological lifespan of Saccharomyces cerevisiae and Schizosaccharomyces pombe, along with their intracellular functions. The low‐molecular weight compounds are also discussed that extend the lifespan of other model organisms. Compounds that have so far only been studied in yeast may soon extend lifespan in other organisms.

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Section: Caffeinementioning

confidence: 99%

Section: Morusin Mulberrin and Cudraflavone Bmentioning

confidence: 99%

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

Section: Low‐molecular Weight Compounds That Extend the Chronological...mentioning

confidence: 99%

See 3 more Smart Citations

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Ohtsuka,

Shimasaki,

Aiba

2024

Advanced Biology

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Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Liu,

Wang,

Jiang

et al. 2024

Advanced Science

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The senescence of aortic valve interstitial cells (VICs) plays a critical role in the progression of calcific aortic valve disease (CAVD). However, the precise mechanisms underlying the senescence of VICs remain unclear, demanding the identification of a novel target to mitigate this process. Previous studies have highlighted the anti‐aging potential of morusin. Thus, this study aimed to explore the therapeutic potential of morusin in CAVD. Cellular experiments reveal that morusin effectively suppresses cellular senescence and cause a shift toward osteogenic differentiation of VICs in vitro. Mechanistically, morusin activate the Nrf2‐mediated antiaging signaling pathway by downregulating CCND1 expression and aiding Keap1 degradation through Trim 25. This activation lead to the upregulated expression of antioxidant genes, thus reducing reactive oxygen species production and thereby preventing VIC osteogenic differentiation. In vivo experiments in ApoE−/− mice on a high‐fat Western diet demonstrate the positive effect of morusin in mitigating aortic valve calcification. These findings emphasize the antiaging properties of morusin and its potential as a therapeutic agent for CAVD.

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Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function

Gao,

Yu,

Zhang

et al. 2024

J of Applied Toxicology

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Mulberrin, a naturally occurring flavone found in mulberry and Romulus Mori, exhibits diverse biological functions. Here, we showed that mulberrin extended both the lifespan and healthspan in C. elegans. Moreover, mulberrin increased the worms' resistance to toxicants and activated the expression of detoxification genes. The longevity‐promoting effect of mulberrin was attenuated in nuclear hormone receptor (NHR) homologous nhr‐8 and daf‐12 mutants, indicating that the lifespan extending effects of mulberrin in C. elegans may depend on nuclear hormone receptors NHR‐8/DAF‐12. Further analyses revealed the potential associations between the longevity effects of mulberrin and the insulin/insulin‐like growth factor signaling (IIS) and adenosine 5′‐monophosphate‐activated protein kinase (AMPK) pathways. Together, our findings suggest that mulberrin may prolong lifespan and healthspan by activating detoxification functions mediated by nuclear receptors.

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Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways

Cited by 9 publications

References 37 publications

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function

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