Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling

Chen, Cunrong; Wang, Jingjing; Chen, Jianfei; Zhou, Lili; Wang, Hui; Chen, Junnian; Xu, Zhihui; Zhu, Shuaijun; Liu, Wei; Yu, Ranjie; Lu, Junli; Luo, Haoteng; Chen, Min; Chen, Weiwen

doi:10.1042/bsr20190190

Cited by 23 publications

(13 citation statements)

References 21 publications

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“…(5) Morusin treatment protects against 2,4,6-trinitrobenzensulfonic acid (TNBS)-induced colitis in rats [ 28 ]. (6) Morusin treatment alleviates inflammatory signaling thereby controlling the outgrowth of mycoplasma pneumonia [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, morusin suppressed STAT1-mediated cytokine secretion in TNF-α- and IFN-γ-stimulated keratinocytes [ 24 ]. Indeed, many studies have already emphasized that the versatile effects of morusin may be associated with downregulation of the NF-κB pathway and its crosstalk with STAT1, STAT3 and Wnt/β-catenin signaling [ 24 , 25 , 26 , 29 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Given that activation of the NF-κB and STAT signaling pathways is one of the downstream events of EGF receptor signaling and since morusin directly binds to the catalytic domain of the EGF receptor for inactivation of EGFR [ 14 ], it is plausible that morusin-mediated blocking of EGFR signaling may contribute to the down-regulation of NF-κB-mediated iNOS induction and NO synthesis, as well as STAT1-mediated cytokine secretion, to result in anti-inflammatory effects.…”

Section: Resultsmentioning

confidence: 99%

“…One such strategy is to provoke cellular and systemic inflammatory responses. Morusin has been administered to a few models of infectious diseases, such as an in vivo mouse model of mycoplasma pneumonia infection, in which morusin treatment efficiently suppressed mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling [ 29 ]. Morusin also appears to exert anti-microbial and anti-viral activities on microorganisms per se ; Pang et al and We et al, demonstrated that morusin has the remarkable capacity to target Staphylococcus aureus and clinical methicillin-resistant Staphylococcus aureus (MRSA) in vitro and in vivo [ 75 , 76 ].…”

Section: Resultsmentioning

confidence: 99%

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The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus

Choi

Cho

Lee

et al. 2020

IJMS

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The root bark of Morus has long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as one of 7 different isoprene flavonoid derivatives in the root bark of Morus. However, the remarkable antioxidant capacity of morusin with the unexpected potential for health benefits over the other flavonoid derivatives has recently sparked scientific interest in the biochemical identification of target proteins and signaling pathways and further clinical relevance. In this review, we discuss recent advances in the understanding of the functional roles of morusin in multiple biological processes such as inflammation, apoptosis, metabolism and autophagy. We also highlight recent in vivo and in vitro evidence on the clinical potential of morusin treatment for multiple human pathologies including inflammatory diseases, neurological disorders, diabetes, cancer and the underlying mechanisms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus

Choi

Cho

Lee

et al. 2020

IJMS

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“…When SARS-CoV-2 invades the respiratory tract and the lung, the cell proliferative pathways of the lung epithelial cells are often activated due to the demand for tissue regeneration during the host immune defense response and inflammation. Under the infected and inflamed conditions, the mucin (MUC)-5B, transforming growth factor (TGF)-β, p38 MAPK, integrin signaling, and Wnt signaling pathways are activated [46] , [47] , [74] , [75] , [76] , [77] , [78] , [79] . SARS-CoV-2 also causes induction of reactive oxygen species (ROS), which turns on cell cycle regulatory genes, leading to lung fibroblast proliferation.…”

Section: Pathogenesis Of Covid-19 and The Treatment Mechanism Of Chmmentioning

confidence: 99%

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

et al. 2020

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The recent coronavirus disease 2019 (COVID-19) pandemic outbreak has caused a serious global health emergency. Supporting evidence shows that COVID-19 shares a genomic similarity with other coronaviruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), and that the pathogenesis and treatment strategies that were applied 17 years ago in combating SARS-CoV and other viral infections could be taken as references in today’s antiviral battle. According to the clinical pathological features of COVID-19 patients, patients can suffer from five steps of progression, starting with severe viral infection and suppression of the immune system and eventually progressing to cytokine storm, multi-organ damage, and lung fibrosis, which is the cause of mortality. Therefore, early prevention of disease progression is important. However, no specific effective drugs and vaccination are currently available, and the World Health Organization is urging the development of novel prevention and treatment strategies. Traditional Chinese medicine could be used as an alternative treatment option or in combination with Western medicine to treat COVID-19, due to its basis on historical experience and holistic pharmacological action. Here, we summarize the potential uses and therapeutic mechanisms of Chinese herbal formulas (CHFs) from the reported literature, along with patent drugs that have been recommended by institutions at the national and provincial levels in China, in order to verify their scientific foundations for treating COVID-19. In perspective, more basic and clinical studies with multiple high-tech and translational technologies are suggested to further confirm the therapeutic efficacies of CHFs.

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“…Research shows that morusin (the effective component of cortex mori ) treatment led to decreased levels of proinflammatory cytokines such as interleukin, IL-6, and IL-1 β , and TNF- α and increased level of anti-inflammatory IL-10 in mice lung tissue. Morusin relieves mycoplasma pneumonia via the inhibition of the activation of Wnt/ β -catenin and NF- κ B pathways [ 27 ]. Semen Descurainiae extract administration significantly reduced mucus production, inflammatory cell infiltration into airways, and eosinophil activation by reducing the expression of type 2 cytokines and inhibiting differentiation and activation of Th2 cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Study on Intervention Mechanism of Yiqi Huayu Jiedu Decoction on ARDS Based on Network Pharmacology

Luo

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Yiqi Huayu Jiedu (YQHYJD) is a traditional Chinese medicine decoction made up of eight traditional Chinese medicines. Although YQHYJD is effectively used to prevent and treat ARDS/acute lung injury (ALI) in rats, the molecular mechanisms supporting its clinical application remain elusive. The purpose of the current study was to understand its lung protective effects at the molecular level using network pharmacology approach. Methods. In an ARDS animal model, the beneficial pharmacological activities of YQHYJD were confirmed by reduced lung tissue damage levels observed on drug treated rats versus control group. We then proposed a network analysis to discover the key nodes based on drugs and disease network. Subsequently, we analyzed interaction networks and screened key targets. Using Western blot to detect the expression level of key targets, the intervention effect of changes in expression level of key targets on ARDS was evaluated. Results. Pathway enrichment analysis of highly ranked genes showed that ErbB pathways were highly related to ARDS. Finally, western blot results showed decreased level of the AKT1 and KRAS/NRAS/HRAS protein in the lung after treatment which confirmed the hypothesis. Conclusion. In conclusion, our results suggest that YQHYJD can exert lung tissue protective effect against the severe injury through multiple pathways, including the endothelial cells permeability improvement, inflammatory reaction inhibition, edema, and lung tissue hemorrhage reduction.

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Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling

Cited by 23 publications

References 21 publications

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Study on Intervention Mechanism of Yiqi Huayu Jiedu Decoction on ARDS Based on Network Pharmacology

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