Mortality trends for tuberculosis in European Union countries, 2000–2010

Al-Rahamneh, Moad J.; Al-Rahamneh, Anas; Guillén-Grima, Francisco; Arnedo-Pena, Alberto; Aguinaga-Ontoso, Inés

doi:10.1016/j.eimc.2017.05.009

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…TB mortality rates have declined globally with an annualised rate of change of −4.1% from 2005 to 2015. Within the European Union, mortality rates declined even faster with an estimated annual percentage change of −8.1% for females and −7% for males between 2000 and 2010 [2]. However, to achieve the milestone for reduction in TB deaths set in the WHO's End TB Strategy, the global case fatality rate (CFR) needs to fall to 10% by 2020 and 6% by 2025 [1].…”

Section: Introductionmentioning

confidence: 99%

“…The UK, like many other European countries, has seen a remarkable decline in TB notifications and mortality over the last 100 years [7]. However, in recent years the decline in mortality has been slower compared with the average TB mortality decline in the European Region between 2000 and 2010 (−4.6% in the UK versus −7% in the European Union) [2]. A possible explanation may be the concentration of the TB epidemic in major cities, among foreign-born residents, recent immigrants and certain groups of socially marginalised citizens [8].…”

Section: Introductionmentioning

confidence: 99%

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Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data

et al. 2019

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IntroductionIn the UK, several hundred patients notified with tuberculosis (TB) die every year. The aim of this article is to describe trends in deaths among notified TB patients, explore risk factors associated with death and compare all-cause mortality in TB patients with age-specific mortality rates in the general UK population.MethodsWe used 2001–2014 data from UK national TB surveillance to explore trends and risk factors for death, and population mortality data to compare age-specific death rates among notified TB patients with annual death rates in the UK general population.ResultsThe proportion of TB patients in the UK who died each year declined steadily from 7.1% in 2002 to 5.5% in 2014. One in five patients (21.3%) was diagnosed with TB post-mortem. Where information was available, almost half of the deaths occurred within 2 months of starting treatment. Risk factors for death included demographic, disease-specific and social risk factors. Age had by far the largest effect, with patients aged ≥80 years having a 70 times increased risk of death compared with those aged <15 years. In contrast, excess mortality determined by incidence ratios comparing all-cause mortality among TB patients with that of the general population was highest among children and the working-age population (15–64 years old).ConclusionsEfforts to control TB and improve diagnosis and treatment outcomes in the UK need to be sustained. Control efforts need to focus on socially deprived and vulnerable groups. There is a need for further in-depth analysis of deaths of TB patients in the UK to identify potentially preventable factors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data

et al. 2019

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“…Regarding mortality, it had decreased across the world in people without HIV infection ( 34 ) , and has the following associated factors: male sex; lower economic power; lower Human Development Index (HDI); higher immigration rate; black ethnicity and higher coinfection coefficients for HIV ( 10 , 13 , 35 - 36 ) ; vulnerable (immunosuppressed) populations, people with circulatory problems and neoplasia; and people with delayed diagnosis and inefficient follow-up ( 37 ) . The decrease in mortality observed in this study may derive from public policies that prioritize the monitoring of the patient, free treatment in the appropriate time, and social protection measures with money transfer ( 38 ) .…”

Section: Discussionmentioning

confidence: 99%

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Sousa

Garcês

Pereira

et al. 2019

Rev. Latino-Am. Enfermagem

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Objective:to analyze the temporal pattern of tuberculosis cure, mortality, treatment abandonment in Brazilian capitals.Method:this is an ecological study whose data source was the Information System of Notifiable Diseases for Tuberculosis (Sistema de Informação de Agravos de Notificação para Tuberculose). For analysis of temporal evolution, regressions by join points were performed considering the annual percentage variation and the significance of the trend change with 95% confidence interval.Results:542,656 cases of tuberculosis were found, with emphasis on a 3% decrease per year in the cure rate for Campo Grande (interval: −5.0 - −0.9) and a 3.5% increase for Rio de Janeiro (interval: 1.9 - 4.7). Regarding abandonment, it decreased 10.9% per year in Rio Branco (interval: −15.8 - −5.7) and increased 12.8% per year in Fortaleza (interval: 7.6 - 18.3). For mortality, a decreasing or stationary tendency was identified, with a greater decrease (7.8%) for Porto Velho (interval:−11.0 - −5.0) and a lower one (2.5%) in Porto Alegre (interval:−4.5 - −0.6).Conclusion:the rates of cure and abandonment are far from the ones recommended by the World Health Organization, showing that Brazilian capitals need interventions aimed at changing this pattern.

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Tuberculosis case fatality is higher in male than female patients in Europe: a systematic review and meta-analysis

Pape,

Karki,

Heinsohn

et al. 2024

Infection

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Purpose Epidemiological TB data indicate differences in infection prevalence, progression rates, and clinical disease incidence between sexes. In contrast, evidence on sex-specific differential (post) TB case fatality in Europe has not been synthesized systematically. Methods We searched electronic databases and grey literature up to December 2020 for studies reporting sex-stratified TB death data for Europe. The JBI critical appraisal tools served for bias risk assessment and subgroup analyses for studying heterogeneity. Random-effects models meta-analyses enabled estimating pooled relative risks of sex-associated TB fatality. Considering associations of comorbidities and risk factors on fatality differences, we applied relative risk meta-regression. Results Based on 17,400 records screened, 117 studies entered quantitative analyses. Seventy-five studies providing absolute participant data with moderate quality and limited sex stratification reported 33 to 235,000 TB cases and 7 to 27,108 deaths. The pooled male-to-female TB fatality risk ratio was 1.4 [1.3–1.5]. Heterogeneity was high between studies and subgroups. Study time, concurrent comorbidities (e.g., HIV, diabetes, cancers), and mean participant ages showed no effect modification. We identified higher male TB fatality in studies with higher homelessness (coefficient 3.18, 95% CI [-0.59 to 6.94], p-value 0.10) and lower migrants proportion (coefficient − 0.24, 95% CI [− 0.5 to 0.04], p-value 0.09). Conclusion We found 30–50% higher TB case fatality for males in Europe. Except for homelessness, migration, and a trend for some comorbidities, assessing effect modification could not reduce our meta-analysis’ high heterogeneity. Public health authorities should take heed of this higher risk of dying in male patients’ treatment services.

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Mortality trends for tuberculosis in European Union countries, 2000–2010

Cited by 4 publications

References 28 publications

Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data

Trends and risk factors for death and excess all-cause mortality among notified tuberculosis patients in the UK: an analysis of surveillance data

Temporal pattern of tuberculosis cure, mortality, and treatment abandonment in Brazilian capitals

Tuberculosis case fatality is higher in male than female patients in Europe: a systematic review and meta-analysis

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