Mortality Risk Factors in Hospitalised Late Adolescent and Adult Sickle Cell Disease Patients

Mohanty, P.; Meher, Srinibas

doi:10.18410/jebmh/2018/30

Cited by 1 publication

(1 citation statement)

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“…Indian SCA patients have been symptomatic, despite having a higher level of HbF; the most common complication is VOC, which needs immediate medical care or else this may lead to the death of the patients 19 , 20 . In the present study, among male and female patients with SCA in both patient and control groups, numbers of male patients were more, which could be due to differential care seeking in this population.…”

Section: Discussionmentioning

confidence: 99%

Impact of hydroxyurea on hospital stay & analgesic utilization in sickle cell anaemia with vaso-occlusive crises

et al. 2022

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Background & objectives: Hydroxyurea (HU) has been useful in preventing sickle cell vaso-occlusive crises (VOC). A few studies also suggest utility of HU, during acute VOC. Sickle cell anaemia (SCA) is of high prevalence in western districts of Odisha State, India, and VOC is a common presentation, despite being mostly of Arab-Indian haplotype. This study was undertaken to evaluate the impact of HU on hospital stay and analgesic utilization in acute painful VOC of SCA. Methods: Homozygous sickle cell disease (HbSS) patients were categorized as cases who were receiving low-dose HU (10 mg/kg/day) and patients who were not on HU were considered as control. Days of hospital stay, analgesic utilization and visual analogue scale (VAS) score in patients were compared with that of control. Analgesics used to control pain were tramadol hydrochloride, ketorolac and diclofenac. Results: A total of 359 homozygous sickle cell disease (SCD) patients with VOC were studied (187 patients and 172 controls). The patient group had lesser mean days of hospital stay (1.4 days less than controls, P <0.001) and required lesser days of analgesic utilization than controls (1.18 days less than controls, P <0.001). Significant differences were observed between patients and controls concerning VAS score and amount of tramadol hydrochloride, ketorolac and diclofenac utilization ( P <0.05). Interpretation & conclusions: In this study, HU was found to have beneficial effects in acute VOC of homozygous SCD, which includes shortening the duration of hospital stay and reducing the net amount of analgesic utilization during hospitalization.

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Section: Discussionmentioning

confidence: 99%