Mortality Risk Factor Stratification in a Retrospective Cohort of Hospitalized Patients with Community Acquired Pneumonia

Abstract

Purpose A retrospective cohort was used to investigate the conditions that affected mortality in hospitalized community-acquired pneumonia (CAP) patients.Methods 1223 patients were identified based on diagnostic codes. T-tests, chi-squared tests, and logistic regression models were used to evaluate the data.Results There were 613 (50%) patients on proton pump inhibitors (PPIs) with a mortality rate of 26.3% vs 13.4% in non-PPI users (P < 0.001). Variables that increased the risk of death included: each decade of age, odds ratio (OR) = 1.15 (95% confidence interval 1.07 to 1.23), congestive heart failure OR = 2.06 (1.46 to 2.91), cancer OR = 1.66 (1.20 to 2.23), cardiovascular disease OR = 2.04 (1.19 to 3.49), and stroke OR = 1.53 (1.05 to 2.23). Statin use was associated with improved mortality, OR = 0.28 (0.13 to 0.59).Conclusion Statin use may improve and PPIs may worsen mortality in CAP.