Mortality risk after herpes zoster infection in end-stage renal disease patients

Ahn, John H; Waller, Jennifer L.; Baer, Stephanie L.; Colombo, Rhonda E; Kheda, Mufaddal; Nahman, N. S.; Turrentine, Jake E.

doi:10.1093/ckj/sfy058

Cited by 10 publications

(10 citation statements)

References 15 publications

(19 reference statements)

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“…HZ infection in CKD is associated with increased complication rate when compared to the general population (44) and a faster progression to ESKD (45). In ESKD HZ infections is associated with a high complication of 35% in those infected and a mortality of 15-50% (46,47). It is notable that while most guidelines recommend HZV in patients ≥ 60-65 years of age, patients with CKD patients have a higher risk of HZ at a younger age compared to the general population (48).…”

Section: Sensitivity Analysismentioning

confidence: 99%

Systematic Review and Meta-analysis of Herpes Zoster Vaccine in Patients With CKD

Hamad

Allam

Sulaiman

et al. 2021

Kidney International Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Sensitivity Analysismentioning

confidence: 99%

Systematic Review and Meta-analysis of Herpes Zoster Vaccine in Patients With CKD

Hamad

Allam

Sulaiman

et al. 2021

Kidney International Reports

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“…20 Despite disease severity, herpes zoster is also of particular concern in the elderly. 21,22 The mean age of subjects in this study was around 60 years old. Given the advancing age, we did NOT nd signi cantly increased disease severity in HZ patients compared with control group.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Herpes Zoster Infection in Patients With Chronic Kidney Disease: A Case-control Study

Wang

Liu

et al. 2021

Preprint

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Background: Chronic kidney disease (CKD) increases the susceptibility to the infection of herpes zoster (HZ). Less is known about the risk factors of HZ in CKD patients.Methods and Participants: This is a case-control study. CKD patients diagnosed with HZ infection between January 2015 and October 2020 in a tertiary hospital were identified. One age- and gender- matched control was paired for each case, matched to the date of initial HZ diagnose. The uni- and multivariate analysis were used to evaluate the risk factors for development of HZ in CKD patients.Results: Forty-six HZ patients and controls were identified. In general, about 80% (72 out of 92) patients were classified at end-stage renal disease (ESRD, CKD Ⅳ to Ⅴ). Multivariate analyses revealed that immunosuppressive agents (odds ratio: 12.50, 95% CI: 1.53-102.26, P=0.021) and dialysis (odds ratio: 3.33, 95% CI: 1.13-9.78, P=0.029) were independent risk factors of HZ in patient with CKD. Conclusion: Immunosuppressive medication and dialysis were associated with HZ infection in CKD. Further guideline may highlight the necessity of zoster vaccine for patients with CKD, who undertake immunosuppressive or dialysis treatment.

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“…The present study has several limitations common to queries of large administrative datasets as we have described. 31 In brief, all diagnoses and procedures were inferred from billing codes or extracted from forms and were not identified using actual medical documentation. However, the size of the dataset may, in part, offset these limitations.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Implantable Cardioverter-defibrillators for Secondary Prevention of Sudden Cardiac Death in Patients with End-stage Renal Disease

Payne¹,

Waller²,

Kheda³

et al. 2020

J Innov Cardiac Rhythm Manage.

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End-stage renal disease (ESRD) constitutes a major burden on the health-care system in the United States, with more than 300,000 patients nationwide being treated with renal replacement therapy. Very few studies to date have evaluated the benefit of implantable cardioverter-defibrillator (ICD) implantation for secondary prevention in patients with ESRD. In this study, we evaluated the efficacy of secondary-prevention ICDs in reducing all-cause mortality in patients on dialysis using the United States Renal Data System (USRDS) database. We queried the USRDS for relevant data between 2004 and 2010. Patients with diagnoses of ventricular fibrillation (VF), ventricular tachycardia (VT), or sudden cardiac arrest (SCA) were included in the study. Patients were excluded from the analysis if they were younger than 18 years; had missing age, sex, or race/ethnicity information; had experienced myocardial infarction; or had an ICD in situ at the time of VF, VT, or SCA diagnosis. The primary endpoint of this study was to determine the efficacy of secondary-prevention ICDs in reducing all-cause mortality in patients on dialysis. A total of 1,442 patients (3.4%) with ESRD had ICD insertion. Patients who received an ICD were predominantly younger, white males with lower Charlson Comorbidity Index and with fewer cardiovascular events. Survival at two years was 53% among those with an ICD relative to 27% among those without an ICD. In this study, we observed a substantial decrease in mortality in patients receiving an ICD for secondary prevention when compared with a cohort of similar patients with a history of VF, VT, or SCA.

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Mortality risk after herpes zoster infection in end-stage renal disease patients

Cited by 10 publications

References 15 publications

Systematic Review and Meta-analysis of Herpes Zoster Vaccine in Patients With CKD

Systematic Review and Meta-analysis of Herpes Zoster Vaccine in Patients With CKD

Risk Factors for Herpes Zoster Infection in Patients With Chronic Kidney Disease: A Case-control Study

Efficacy of Implantable Cardioverter-defibrillators for Secondary Prevention of Sudden Cardiac Death in Patients with End-stage Renal Disease

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