Mortality rates and prognostic factors in patients with malignant salivary tumors

Israel, Yair; Rachmiel, Adi; Gourevich, Konstantin; Nagler, Rafael M.

doi:10.1007/s12032-019-1284-y

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…Univariate analysis suggested that cT4 stage, cN+ stage, stage IV disease, and facial nerve invasion were prognostic factors for parotid carcinoma. In terms of histological grade, in the first half of this study, the 5-year DSS rates for low-/intermediate-grade patients and high-grade patients were 94.4% and 34.3%, respectively, which were significantly different ( p = 0.026), similar to those in other reports [ 23 , 33 ]. Although postoperative radiotherapy is effective in preventing local and cervical lymph node recurrences in patients with a poor prognosis, distant metastasis may ultimately determine the prognosis.…”

Section: Discussionsupporting

confidence: 89%

“…Some reports have suggested that prophylactic neck dissection should be considered in high-grade and T4 cases because of the high rate of occult lymph node metastasis [ 22 ]. Other studies have indicated that prophylactic neck dissection in cN0 cases does not improve survival and that the benefit of prophylactic neck dissection is limited in terms of prolonging survival [ 23 , 24 , 25 ]. In this study, only 1 of 5 cN0 patients had occult cervical lymph node metastasis in Group A, and 3 of the 36 cN0 patients showed late-onset cervical lymph node metastases in Group B, which were successfully managed by salvage neck dissection.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Changing Surgical Strategies on Clinical Outcomes in Patients with Parotid Carcinoma: A 53-Year Single-Institution Experience

et al. 2021

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Background and Objectives: We investigated the clinical outcomes of patients who underwent surgery for parotid carcinoma in a single institution during a 53-year period. This study aimed to estimate the impact of changing the surgical approach to parotid carcinoma on clinical outcomes including the incidence rate of the facial nerve palsy. Materials and Methods: Sixty-seven patients with parotid carcinoma who underwent surgery between 1966 and 2018 were retrospectively reviewed. Group A consisted of 29 patients who underwent surgery from 1966 to 2002, and Group B consisted of 38 patients from 2002 to 2018. Treatment outcomes were estimated. Additionally, candidate prognostic factors of Group B, the current surgical approach group, were evaluated. Results: Partial parotidectomy and total parotidectomy were performed in 35 and 32 patients, respectively. Partial parotidectomy was performed in 4 patients in Group A and 31 patients in Group B, with a predominant increase in Group B. The facial nerve was preserved in 43 patients, among whom 8 in Group A (8/17; 47.1%) and 7 in Group B (7/26; 26.9%) had temporary postoperative facial nerve palsy. Postoperative radiotherapy was performed on 35 patients. The 5-year OS, DSS, and DFS rates for Group A were 77.1%, 79.9%, and 71.5%, respectively. The 5-year OS, DSS, and DFS rates for Group B were 77.1%, 77.1%, and 72.4%, respectively. Clinical T4 stage, clinical N+ stage, stage IV disease, and tumor invasion of the facial nerve were independent prognostic factors in Group B. Conclusions: The incidence of facial nerve palsy in the current surgical approach group decreased compared with that in the previous surgical approach group. The current surgical management and treatment policies for parotid carcinoma have led to improved outcomes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Impact of Changing Surgical Strategies on Clinical Outcomes in Patients with Parotid Carcinoma: A 53-Year Single-Institution Experience

et al. 2021

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“…The choice of appropriate treatment has a direct impact on patient prognosis, but it is not the only prognostic factor. Findings indicate clinical factors such as histopathological type and grade of lesion, advanced tumor stage, facial nerve involvement, vascular invasion, lymph node metastasis, and distant metastasis, negatively affect prognosis [ 14 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. In addition, demographic factors such as gender or age are also factors that affect prognosis [ 14 , 26 , 31 , 34 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

Žůrek

Jasak

Jaros

et al. 2022

IJERPH

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(1) Background: Malignant tumours of the salivary glands have different clinical and histopathological characteristics. They most commonly involve the parotid gland. Histopathologically, the most common are mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (AdCC), acinic cell carcinoma (AcCC), adenocarcinoma, carcinoma in pleomorphic adenoma (CPA), and squamous cell carcinoma (SCC). (2) Methods: We analysed 2318 patients with malignant parotid gland tumours reported to the National Cancer Registry (NCR) in Poland over 20 years (1999–2018). The demographic characteristics of patients, clinical factors, and overall survival (OS) were analysed. (3) Results: The average age was 61.33 ± 16.1 years. The majority were males (55%) and urban citizens (64%). High percentage of carcinomas was diagnosed in locoregional (33.7%) and systemic (10.4%) stadium. The most prevalent diagnoses were SCC (33.3%) and adenocarcinoma (19.6%). Surgical resection with adjuvant RT (42.1%) was the most common treatment. The OS analysis showed a median survival time of 5.6 years. The most favorable median OS was found in patients with AcCC (18.30 years), the worst for SCC (1.58 years). (4) Conclusion: AcCC has the best prognosis and SCC the worst. Tumour stadium, treatment, and demographic factors affect prognosis. Improvements in diagnosis and re-evaluation of treatment standards are necessary to enhance the outcome of patients with parotid gland cancers in Poland.

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Mortality rates and prognostic factors in patients with malignant salivary tumors

Cited by 2 publications

References 32 publications

Impact of Changing Surgical Strategies on Clinical Outcomes in Patients with Parotid Carcinoma: A 53-Year Single-Institution Experience

Impact of Changing Surgical Strategies on Clinical Outcomes in Patients with Parotid Carcinoma: A 53-Year Single-Institution Experience

Clinico-Epidemiological Analysis of Most Prevalent Parotid Gland Carcinomas in Poland over a 20-Year Period

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