Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up

Arnold, Donald M.; Julian, Jim A.; Walker, Irwin

doi:10.1182/blood-2005-11-4407

Cited by 72 publications

(78 citation statements)

References 25 publications

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“…Of them, 6242 were positive for HIV and 10508 were negative for HIV. Fourteen studies assessed the histological cirrhosis [9,18,19,21,[27][28][29][30][31][32]38,39,41,42] , 7 studies assessed the death [17,22,23,[34][35][36]40] , 3 studies assessed the decompensated liver disease [15,26,37] , 2 studies assessed the outcome of decompensated liver disease and death [16][17][18][19][20][21][22][23][24][25] , 1 study assessed the outcome of histological cirrhosis, hepatocellular carcinoma and death [20] , 1 study assessed the outcome of histological cirrhosis and death [24] , and 1 study assessed the outcome of hepatocellular carcinoma and death [33] , respectively. Most studies did not provide a racial distribution.…”

Section: Deng Lp Et Al Impact Of Hiv Infection On Hcv Infectionmentioning

confidence: 99%

Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis

Deng¹,

Gui²,

Zhang³

et al. 2009

WJG

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AIM:To analyze the influence of human immunodeficiency virus (HIV) infection on the course of hepatitis C virus (HCV) infection. METHODS:We performed a meta-analysis to quantify the effect of HIV co-infection on progressive liver disease in patients with HCV infection. Published studies in the English or Chinese-language medical literature involving cohorts of HIV-negative and -positive patients coinfected with HCV were obtained by searching the PUBMED, EMBASE and CBM. Data were extracted independently from relevant studies by 2 investigators and used in a fixed-effect meta analysis to determine the difference in the course of HCV infection in the 2 groups. RESULTS:Twenty-nine trails involving 16 750 patients were identified including the outcome of histological fibrosis or cirrhosis or de-compensated liver disease or hepatocellular carcinoma or death. These studies yielded a combined adjusted odds ratio (OR) of 3.40 [95% confidence interval (CI) = 2.45 and 4.73]. Of note, studies that examined histological fibrosis/ cirrhosis, decompensated liver disease, hepatocellular carcinoma or death had a pooled OR of 1.47 (95% CI = 1.27 and 1.70), 5.45 (95% CI = 2.54 and 11.71), 0.76 (95% CI = 0.50 and 1.14), and 3.60 (95% CI = 3.12 and 4.15), respectively. CONCLUSION:Without highly active antiretroviral therapies (HAART), HIV accelerates HCV disease progression, including death, histological fibrosis/ cirrhosis and decompensated liver disease. However, the rate of hepatocellular carcinoma is similar in persons who had HCV infection and were positive for HIV or negative for HIV.

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Section: Deng Lp Et Al Impact Of Hiv Infection On Hcv Infectionmentioning

confidence: 99%

Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis

Deng¹,

Gui²,

Zhang³

et al. 2009

WJG

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“…Co-infection s associated with a higher mortality than mono infection with either virus alone [46]. This liver-related mortality decreased following introduction of HAART (highly active antiretroviral therapy) [47].…”

Section: Route Of Transmissionmentioning

confidence: 99%

HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis

BU¹

2013

J AIDS Clin Res

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“…[13][14][15] Younger age at the time of HIV seroconversion has been associated with improved survival. 14,16 Most HIV-infected hemophilia patients are coinfected; among 458 HIV-positive hemophilia A and B patients in Canada, 96.5% were hepatitis C (HCV) positive. 14 Both cumulative incidence of end-stage liver disease and fatality due to liver failure have been reported to be significantly increased in the dually infected hemophiliac compared with the HCV-monoinfected hemophiliac.…”

Section: Viral Diseasementioning

confidence: 99%

The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues

Philipp

2010

Hematology

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Improvements in hemophilia care and antiviral treatments have resulted in increases in median life expectancy for persons with congenital hemophilia A and B. Currently, 2% of hemophilia A and B patients surveyed in US comprehensive hemophilia treatment centers are 65 years of age or older and 15% are 45 years or older. Many of the complications of hemophilia, including intracranial hemorrhage, joint disease, and inhibitor development, increase with increasing age. Hepatocellular carcinoma and end-stage liver disease are increasing in the older hemophilia population due to infection with hepatitis C (HCV) and HCV/HIV coinfection. Older hemophilia patients also now face the same medical conditions associated with aging in the general population, including cardiovascular disease and cancer. Complex hemostatic management, sometimes in conjunction with antithrombotic management, with extensive cross-specialty clinical and laboratory coordination may be required for the care of the older hemophilia patient. Because elderly hemophilia patients currently represent a small portion of the overall hemophilia population, there is little in the way of clinical data to guide recommendations. Registry databases and cooperative group studies are needed for the development of evidence-based guidelines for the older hemophilia population, which is anticipated to expand in the future.

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Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up

Cited by 72 publications

References 25 publications

Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis

Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis

HIV Co-Infection with Hepatotropic Viruses and Mycobacterial Tuberculosis

The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues

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