Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data

Cheng, Xuyang; Nayyar, Saleem; Wang, Mei; Li, Xuemei; Sun, Yi; Huang, Wen; Zhang, Ling; Wu, Hua; Jia, Qiang; Liu, Wenhu; Sun, Xuefeng; Li, Jijun; Lun, Lide; Zhou, Chunhua; Cui, Taigen; Zhang, Aihua; Wang, Kai; Wang, Shixiang; Sun, Weiming; Zuo, Li

doi:10.1093/ndt/gfs326

Cited by 51 publications

(55 citation statements)

References 3 publications

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“…However, a 35% reduction in HR was identified in patients with serum Ca level over 2.5 mmol/L at baseline. The mortality rate was 14.6%, similar to that (13.9%) reported by Cheng et al in 2013[8]. Ageing (≥50 yrs),diabetes and hypertension which were presented as primary causes of ESRD, all remained as strong predictors of mortality.…”

Section: Discussionsupporting

confidence: 83%

“…First of all, this is a retrospective observational study rather than a randomized controlled study. Secondly, as stated in a previous study [8], the Beijing hemodialysis dataset only referred to city but not national. Some primary causes of ESRD were uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…One of the major missions of BJHDQCIC was to do end-stage renal disease (ESRD) registration [7, 8]. From 2007, BJHDQCIC started to collect patient-level data from 120 HD facilities in Beijing and an annual data report (ADR) has been issued thereafter.…”

Section: Methodsmentioning

confidence: 99%

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Association of CKD-MBD Markers with All-Cause Mortality in Prevalent Hemodialysis Patients: A Cohort Study in Beijing

Zhang

Zuo

et al. 2017

PLoS ONE

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The relationships between all-cause mortality and serum intact parathyroid hormone (iPTH), calcium, and phosphate are fairly diverse in patients on maintenance hemodialysis according to prior studies. This study evaluated the association of chronic kidney disease-mineral and bone disorder (CKD-MBD) markers with all-cause mortality in prevalent hemodialysis patients from 2007 to 2012 in Beijing, China. A cohort, involving 8530 prevalent hemodialysis patients who had undergone a 6–70 months follow-up program (with median as 40 months) was formed. Related data was recorded from the database in 120 hemodialysis centers of Beijing Health Bureau (2007 to 2012). Information regarding baseline demographics, blood CKD-MBD markers and all-cause mortality was retrospectively reviewed. By using multivariate Cox regression model analysis, patients with a low iPTH level at baseline were found to have greater risk of mortality (<75pg/ml, HR = 1.36, 95% confidence interval (CI) 1.16–1.60) than those with a baseline iPTH level within 150–300 pg/ml. Similarly, death risk showed an increase when the baseline serum calcium presented a low level (<2.1mmol/L, HR = 1.54; 95% CI 1.37–1.74). Levels of baseline serum phosphorus were not associated with the risk of death. Similar results appeared through the baseline competing risks regression analysis. Patients with a lower level of serum iPTH or calcium are at a higher risk of all-cause mortality compared with those within the range recommended by Kidney Disease Outcome Quality Initiative (KDOQI) guidelines.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Association of CKD-MBD Markers with All-Cause Mortality in Prevalent Hemodialysis Patients: A Cohort Study in Beijing

Zhang

Zuo

et al. 2017

PLoS ONE

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“…The proportion of ICED levels 0-1, was 75% in this study, compared to that of the HEMO study, 35.1% [9]. The better survival rate may also be explained by the racial difference, all Asian in this study, compare to the racial diversity of the US, 54% patients being white, 38.3% black, and 3.7% Asian [16,17]. …”

Section: Discussionmentioning

confidence: 61%

Dialysis Dose and Risk Factors for Death Among ESRD Patients Treated with Twice-Weekly Hemodialysis: A Prospective Cohort Study

et al. 2014

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Background/Aims: We aimed to define the dosing and risk factors for death in patients undergoing twice-weekly hemodialysis. Methods: A prospective multi-center cohort study was conducted with one-year observation. Patients treated with twice- or thrice-weekly hemodialysis were identified. Death and first admission were the outcomes. spKt/V was a factor of interest. Results: We enrolled 504 twice-weekly and 169 thrice-weekly hemodialysis patients. The mean weekly values of spKt/V in the two groups were 3.4 and 5.1. The one-year survival rate and times to hospitalization were similar in both groups. The hazard ratios for death in higher spKt/V quartile was not associated with lower mortality, p = 0.70. The four significant predictors for death were serum albumin, HR = 2.6, current smoking, HR = 19.3, age, HR = 1.1, and the Index of Coexistent Disease [ICED], HR = 1.9. Conclusion: The effect of spKt/V on short-term mortality was not obvious in twice-weekly dialysis patients. Attention should be paid to patients who smoke, have hypoalbuminemia, are elderly, or have a high ICED.

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“…Furthermore, in addition to having a high prevalence of traditional CVD risk factors such as diabetes and hypertension, dialysis patients also have a number of risk factors related to their kidney dysfunction. Some of these risk factors are angiosteosis, vascular stiffness, accumulation of circulating inflammatory mediators and autonomic dysfunction, which result in CVD becoming the most common cause of morbidity and mortality in patients with CKD receiving dialysis, accounting for 40% [13] . Recent evidence also elucidated an increased incidence and accelerated progress of atherosclerosis in patients with CKD receiving dialysis compared with that of the conventional CVD [14] .…”

Section: Discussionmentioning

confidence: 99%

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

Feng

Wang³

2015

Blood Purif

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Background/Aims: To evaluate the relationship between plasma hydrogen sulfide (H₂S) and cardiovascular risk markers, including pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in chronic hemodialysis (CHD) patients and further investigate the underlying cardiovascular protection mechanism of H₂S. Methods: CHD patients, 113 of them, were studied. Plasma H₂S was measured through zinc acetate reaction. cPKCβII membrane translocation and phosphorylation of Akt were detected by western blot. Results: Lower plasma H₂S level in CHD patients was predictor of an increased PP, LVMI and IMT. Patients with lower H₂S had a lower survival at the end of the study. H₂S was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. CHD patients with lower H₂S showed an increase of cPKCβII activation, but phosphorylation of Akt decreased. The level of VCAM-1 and ICAM-1 increased significantly. Conclusions: Lower plasma H₂S in CHD patients is associated with cardiovascular risk factors and mortality, which may be mediated by the cPKCβII/Akt pathway and further VCAM-1/ICAM-1 upregulation.

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Mortality rates among prevalent hemodialysis patients in Beijing: a comparison with USRDS data

Cited by 51 publications

References 3 publications

Association of CKD-MBD Markers with All-Cause Mortality in Prevalent Hemodialysis Patients: A Cohort Study in Beijing

Association of CKD-MBD Markers with All-Cause Mortality in Prevalent Hemodialysis Patients: A Cohort Study in Beijing

Dialysis Dose and Risk Factors for Death Among ESRD Patients Treated with Twice-Weekly Hemodialysis: A Prospective Cohort Study

Lower Hydrogen Sulfide Is Associated with Cardiovascular Mortality, Which Involves cPKCβII/Akt Pathway in Chronic Hemodialysis Patients

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