Mortality Rate of Bullous Pemphigoid in a US Medical Center

Colbert, Rand L.; Allen, David M.; Eastwood, Daniel; Fairley, Janet A.

doi:10.1111/j.0022-202x.2004.22504.x

Cited by 90 publications

(95 citation statements)

References 20 publications

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“…Interestingly, although a recent study including 223 patients found a 1-year mortality rate of 23% [17], two reports from the USA demonstrated a 1-year mortality rate of 10.8 and 15%, respectively, whereas another study found a 2-year mortality rate of 6% [28,29,30]. The latter figures probably reflect differences in patients' recruitment between European and USA centers.…”

Section: Discussionmentioning

confidence: 99%

Mortality Rate in Bullous Pemphigoid: A Retrospective Monocentric Cohort Study

et al. 2012

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Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease and is associated with an increased mortality. The end points of our study were to evaluate the mortality rate in a retrospective cohort of BP patients followed up to 5 years after the diagnosis and to determine prognostics factors. Methods: All new cases of BP diagnosed between 1990 and 2003 in the University Hospital of Geneva were retrospectively collected. 60 patients were included, 47 (88.6%) of whom were treated with a combination of corticosteroids and chlorambucil. Results: The 1-year, 2-year and 5-year probabilities of death were 26.7, 37.1 and 60.8%, respectively. Old age, dementia and use of chlorambucil at initial doses of 6 mg/day, but not at lower doses, were associated with poor prognosis in multivariate analysis. Conclusion: Our study confirms that BP is associated with a high mortality. The observed mortality rates are however higher than those of previous studies, which is probably related to the inclusion of more debilitated patients.

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Section: Discussionmentioning

confidence: 99%

Mortality Rate in Bullous Pemphigoid: A Retrospective Monocentric Cohort Study

et al. 2012

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“…It is likely that the poor prognosis of these patients may be responsible for the observed difference of BP patients’ survival rate between Europe and the United States [29, 30]. …”

Section: Discussionmentioning

confidence: 99%

Neurological Disorders in Patients with Bullous Pemphigoid

et al. 2007

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Background: Unexpected cases of bullous pemphigoid (BP) have been reported in adult patients with various neurological disorders suggesting a possible relationship between these diseases. Objectives: (1) To determine the prevalence and types of neurological disorders in patients with BP, (2) to assess patients’ functional impairment, and (3) to compare the clinical and biological findings as well as prognosis of BP patients presenting with or without neurological disorders. Methods: BP patients with neurological disorders were selected in a series of 341 consecutive BP patients treated in 20 French Dermatology Departments. Functional impairment was prospectively assessed using the Karnofsky score which is a measure of patients’ general condition. Results: At least one neurological disorder was present in 123 of the 341 BP patients (36%). They primarily consisted of dementia (n = 68; 20%; 95% CI: 16–25%), cerebral stroke (n = 52; 15%; 95% CI: 4–19%), and/or Parkinson’s disease or parkinsonism (n = 32; 9%; 95% CI: 7–13%). BP patients with neurological disease were older than patients without neurological disease (83.8 ± 7.5 years vs. 79.3 ± 10.3 years, p < 10^–4). They also had a lower Karnofsky score (47 ± 19% vs. 74 ± 20%, p < 10^–4). One-year overall survival rates of the two groups were 50.8% (95% CI: 41.8–59.7) and 78.7% (95% CI: 73.0–84.2), respectively (p < 10^–4). In contrast, the number of bullae and main biological features at baseline were not different between the two groups of patients. Conclusion: This study demonstrated a high frequency of neurological disorders, particularly dementia, in BP patients. Most of these patients had a severe functional impairment and a poor prognosis.

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“…Çalışmamızda ise kadın erkek oranı yaklaşık olarak birbirine eşit bulunmuştur. Tanı anındaki ortalama yaş değerlendirildiğinde 70,17±16,98 yıl olarak saptadı, bu değer literatürle uyumlu bulundu (73,7-82,4±7,4 yıl) 6,8,9,19,20 . Literatürlerde yaşlı popülasyonda erkek cinsiyet hakimiyeti bulunmuştur 2,11,12 .…”

Section: Introductionunclassified

“…Avrupadan, BP'nin bir yıllık mortalite oranlarına yönelik çok çeşitli yayınlar mevcuttur. Bu çalışmalarda mortalite oranı %10,8-41 olarak belirlenmiştir 20,21,24,25 . Ülkemizden Akay ve arkadaşlarının yaptıkları çalışmada ise mortalite oranı %19,3 olarak hesaplanmıştır 16 .…”

Section: Introductionunclassified

Büllöz pemfigoidli hastalarda 3 yıllık gözlem: 29 olgu

Ekiz¹,

Şen²,

Rifaioğlu³

et al. 2013

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ÖzetAmaç: Büllöz pemfigoid (BP) kronik, otoimmun subepidemal büllöz bir hastalıktır. Çalışmamızdaki amaç, son 3 yılda kliniğimizde BP tanısı konulan olguların klinik ve epidemiyolojik özelliklerini belirlemek ve sonuçlarımızı ülkemizdeki ve dünyanın diğer yerlerindeki sonuçlarla karşılaştırmaktır. GereçveYöntem:Ocak 2009 ve Ocak 2013 tarihleri arasında Dermatoloji polikliniğimize başvuran, klinik ve histopatolojik olarak BP tanısı alan hastaların dosyaları retrospektif olarak değerlendirildi. Hastaların yaş, cinsiyet, oral mukoza tutulumu, kaşıntının varlığı, hastalık süresi, tetikleyici faktör bulunup bulunmaması, deri lezyonlarının özellikleri, biyopsi örneklerinin direk immünofloresan (DIF) inceleme sonuçları, tedavide kullanılan ilaçlar, nüks ve eksitus oranları ve saptanabilen ölüm nedenleri gibi klinik ve demografik verileri kaydedildi. Bulgular:Çalışmaya alınan 29 hastanın %48,3'ü kadın, %51,7'i erkekti. Yaş ortalamaları 70,17 yıl iken, ortalama hastalık suresi 15,41 aydı. Oral mukoza tutulumu beş, kaşıntı 24 olguda saptandı. Tetikleyici faktör olarak üç olguda ilaç, bir olguda da malinite belirlendi. DIF inceleme sonuçlarında dermoepidermal bileşkede lineer IgG ve C3 depolanması 12 olguda, C3 depolanması 10 olguda mevcuttu. Hastalara başlangıç tedavisi olarak 11 hastaya topikal kortikosteroid, altı hastaya tetrasiklin and nikotinamid kom-binasyonu, 10 hastaya sistemik kortikosteroid tedavisi verildi. Yedi hastada verilen ilk tedaviden sonra bir yıl içinde nüks meydana geldi. Hastane içi mortalite iki hastada görüldü. Sonuç: Çalışmamızda son 3 yılda kliniğimizde BP tanısı konulan hastalarının klinik ve epidemiyolojik verileri sunulmuştur. İlimiz farklı etnik gruplardan oluşan heterojen bir popülasyon olduğu için, çalışmamızın ülkemizdeki BP ile ilgili epidemiyolojik verilerin oluşturulmasında katkıda bulunacağına inanıyoruz. Ancak bu konuda yapılmış prospektif, daha uzun süreli ve çok merkezli çalışmalara ihtiyaç duyulmaktadır. Sum maryBackgroundandDesign:Bullous pemphigoid (BP) is a chronic, autoimmune, subepidermal blistering skin disease. The aim of this study was to determine the clinico-epidemiological characteristics of patients diagnosed with BP in our clinic and to compare the results with those in other studies in our country and in the world. Materials and Methods:We retrospectively evaluated medical records of patients with BP diagnosed by clinical and histopathological examinations in our clinic from January 2009 to January 2013. We evaluated data on demographic characteristics, age, sex, existence of oral mucosal lesions, association of pruritus, duration of the disease, presence of triggering factors, features of the skin lesions, results of direct immunofluorescence (DIF) investigations, drug intake, recurrence and mortality rates and causes of de-tected mortality in all patients. Results:Of the 29 patients included in the study, %48.3 were female, %51.7 were male. The average age was 70.17 years and the mean duration of the disease was 15.41 months. We detected oral mucosal involvement in...

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Mortality Rate of Bullous Pemphigoid in a US Medical Center

Cited by 90 publications

References 20 publications

Mortality Rate in Bullous Pemphigoid: A Retrospective Monocentric Cohort Study

Mortality Rate in Bullous Pemphigoid: A Retrospective Monocentric Cohort Study

Neurological Disorders in Patients with Bullous Pemphigoid

Büllöz pemfigoidli hastalarda 3 yıllık gözlem: 29 olgu

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