Mortality patterns among workers exposed to arsenic, cadmium, and other substances in a copper smelter

Marsh, Gary M.; Esmen, Nurtan A.; Buchanich, Jeanine M.; Youk, Ada O.

doi:10.1002/ajim.20714

Cited by 22 publications

(17 citation statements)

References 36 publications

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“…In 2005, we systematically reviewed the occupational evidence and concluded that methodological limitations precluded reaching conclusions in favor or against an association [6]. Since then, results from three cohorts of tin and copper workers exposed to inhaled arsenic and CVD mortality endpoints have been published [71–73]. All three studies found a consistently increased risk of stroke mortality among exposed workers compared to external reference populations, but results were inconsistent for CVD and CHD mortality [71–73].…”

Section: Discussionmentioning

confidence: 99%

“…Since then, results from three cohorts of tin and copper workers exposed to inhaled arsenic and CVD mortality endpoints have been published [71–73]. All three studies found a consistently increased risk of stroke mortality among exposed workers compared to external reference populations, but results were inconsistent for CVD and CHD mortality [71–73]. The use of external comparisons, the healthy worker effect, uncertainties in exposure assessment and outcome assessment, and likely exposures to multiple toxicants limit the interpretability of these studies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Moon

Güallar

Navas‐Acien

2012

Curr Atheroscler Rep

302

145

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In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037–49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05–1.67), 1.89 (95 % CI: 1.33–2.69), 1.08 (95 % CI: 0.98–1.19), and 2.17 (95 % CI: 1.47–3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Moon

Güallar

Navas‐Acien

2012

Curr Atheroscler Rep

302

145

View full text Add to dashboard Cite

show abstract

“…In 2005, we systematically reviewed the occupational evidence and concluded that methodological limitations precluded reaching conclusions in favor or against an association [6]. Since then, results from three cohorts of tin and copper workers exposed to inhaled arsenic and CVD mortality endpoints have been published [71][72][73]. All three studies found a consistently increased risk of stroke mortality among exposed workers compared to external reference populations, but results were inconsistent for CVD and CHD mortality [71][72][73].…”

Section: Occupational Studiesmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disease: An Updated Systematic Review

Moon¹,

Güallar²,

Navas‐Acien³

2013

ISEE Conference Abstracts

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In epidemiologic studies, high-chronic arsenic exposure has been associated with cardiovascular disease, despite methodological limitations. At low-moderate arsenic levels, the evidence was inconclusive. Here, we update a previous systematic review (Am J Epidemiol 2005;162: 1037-49) examining the association between arsenic exposure and cardiovascular disease. Eighteen studies published since 2005 were combined with 13 studies from the previous review. We calculated pooled relative risks by comparing the highest versus the lowest exposure category across studies. For high exposure (arsenic in drinking water > 50 μg/L), the pooled relative risks (95 % confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were 1.32 (95 % CI: 1.05-1.67), 1.89 (95 % CI: 1.33-2.69), 1.08 (95 % CI: 0.98-1.19), and 2.17 (95 % CI: 1.47-3.20), respectively. At low-moderate arsenic levels, the evidence was inconclusive. Our review strengthens the evidence for a causal association between highchronic arsenic exposure and clinical cardiovascular endpoints. Additional high quality studies are needed at low-moderate arsenic levels.

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“…The hypothesis that cadmium may be a risk factor of pancreatic cancer was first proposed in 2000 in a meta-analysis of three studies including individuals with occupational exposure (Schwartz and Reis 2000) and has been investigated in several occupational studies among workers in cadmium-emitting industries and smelters (Binks et al 2005; Elinder et al 1985; Jarup et al 1998; Marsh et al 2009; Sorahan et al 1995). However, the patterns of pancreatic cancer mortality by cadmium exposure in the general population, in which a great majority do not have a job that substantially increases the possibility of cadmium exposure, have not been examined extensively.…”

Section: Introductionmentioning

confidence: 99%

Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case–control studies among individuals without occupational exposure history

Chen

Xun

Nishijo

et al. 2015

Environ Sci Pollut Res

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Pancreatic cancer is one of the most deadly types of cancer for both genders. Classified as a human carcinogen, cadmium has been related to diverse cancers. However, the association between cadmium exposure and the risk of pancreatic cancer is still unclear. We quantitatively reviewed the observational studies on the association of cadmium exposure with pancreatic cancer risk among individuals without occupational exposure history published through July 2014 in PubMed by using a fixed–effects model. Four prospective cohort studies (112,934 participants with 335 events) and two case-control studies (177 cases and 539 controls) were identified. The summarized relative risk (RR) with a 95% confidence interval (CI) was 2.05 (95% CI=1.58 – 2.66), comparing the highest to the lowest category of cadmium exposure. This positive association persisted in men (RR=1.78; 95% CI=1.04 – 3.05), but not in women (RR=1.02; 95% CI=0.63 – 1.65). Further research is needed to provide more solid evidence on the association of cadmium exposure with pancreatic cancer risk and to elucidate the underlying biological mechanism of the potential gender difference.

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Mortality patterns among workers exposed to arsenic, cadmium, and other substances in a copper smelter

Cited by 22 publications

References 36 publications

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

Arsenic Exposure and Cardiovascular Disease: An Updated Systematic Review

Cadmium exposure and risk of pancreatic cancer: a meta-analysis of prospective cohort studies and case–control studies among individuals without occupational exposure history

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