Mortality of workers exposed to 2 methyl-4 chlorophenoxyacetic acid.

Coggon, David; Pannett, Brian; Winter, P D; Acheson, E D; Bonsall, Julie

doi:10.5271/sjweh.2113

Cited by 74 publications

(42 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this result is not statistically significant, it is in agreement with earlier findings (10). Several other studies of workers exposed to herbicides did not however produce any evidence of such a relationship.…”

Section: Discussionsupporting

confidence: 91%

“…In several other epidemiologic studies excesses of mortality from multiple myeloma have been reported . Coggon et al (10), for instance , observed five deaths from multiple myeloma compared with three expected deaths in a cohort of workers exposed to 2,4-dichlorophenoxyaceticacid and other phenoxy acid herbicides. In a case-referent study of multiple myeloma Pearce et al (II) noted an odds ratio of 1.3 for farmers who had ever sprayed agricultural chemicals.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer mortality among licensed herbicide applicators.

Swaen¹,

Vliet²,

Slangen³

et al. 1992

Scand J Work Environ Health

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Cancer mortality among licensed herbicide applicators.

Swaen¹,

Vliet²,

Slangen³

et al. 1992

Scand J Work Environ Health

View full text Add to dashboard Cite

“…Many epidemiologic studies have been conducted and are currently underway to evaluate the chronic effects of these pesticides in occupational groups, such as manufacturers, professional turf applicators, farmers, forestry and railroad workers, Vietnam veterans and others ( Axelson et al, 1980;Ott et al, 1980;Riihimaki et al, 1982;Coggon et al, 1986;Coggon et al, 1991;Hoar et al, 1986;Pearce et al, 1986;Hoar Zahm, 1987;Lynge, 1987;Lynge, 1993;Vineis et al, 1987;Bond et al, 1988;Eriksson et al, 1990;Wigle et al, 1990;Green, 1991;Lerda and Rizzi, 1991;Saracci et al, 1991;Swaen et al, 1992;Bloemen et al, 1993;Bueno de Mesquita et al, 1993;Kogevinas et al, 1993;Kogevinas et al, 1997;Alavanja et al, 1996;Zahm, 1997;Zahm et al, 1990). Although the current weight of epidemiological evidence suggests an association between the use of 2,4 -D and some cancers, a cause -effect relationship has not been established.…”

Section: Introductionmentioning

confidence: 99%

Development of models to predict dose of pesticides in professional turf applicators

Harris

Sass-Kortsāk

Corey

et al. 2002

J Expo Sci Environ Epidemiol

View full text Add to dashboard Cite

Epidemiologic studies designed to assess the chronic effects of pesticides are limited by inadequate measurements of exposures. Although cohort studies have been initiated to evaluate the effects of 2,4 -dichlorophenoxyacetic acid ( 2,4 -D ) and other pesticides in professional turf applicators, they may have limited power to detect significant health risks and may be subject to bias from exposure measurement error. In this study, the doses of 2,4 -D, mecoprop [ 2 -( 4 -chloro -2 methylphenoxy ) propionic acid, MCPP ] and dicamba ( 3,6 -dichloro -o -anisic acid ) were evaluated in a group of 98 professional turf applicators from 20 companies across southwestern Ontario. During a 1 -week period ( Saturday to Thursday ), the volume of pesticide ( active ingredient ) applied was only weakly related to the total dose of 2,4 -D absorbed ( R 2 = 0.21 ). Two additional factors explained a large proportion of variation in dose: the type of spray nozzle used and the use of gloves while spraying. Individuals who used a fan -type nozzle had significantly higher doses than those who used a gun -type nozzle. Glove use was associated with significantly lower doses. Job satisfaction and current smoking influenced the dose but were not highly predictive. In the final multiple regression models predicting total absorbed dose of 2,4 -D and mecoprop, approximately 63 -68% of the variation was explained. The future application of these models for epidemiologic research will depend on the availability of information and records from employers, the feasibility of contacting study subjects and cost.

show abstract

“…They suggested that MCPA was probably a causative agent of leukemia. Recently, Coggon et al (1986) reported one case of soft tissue sarcoma and three cases of nasal cancer among 4078 workers whose jobs entailed exposure to MCPA. But, they did not give a conclusive answer as to the carcinogenicity of MCPA.…”

Section: Resultsmentioning

confidence: 99%

Chronic toxicity of 2-methyl-4-chlorophenoxyacetic acid(MCPA) in mice.

Takagi

1990

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Mortality of workers exposed to 2 methyl-4 chlorophenoxyacetic acid.

Cited by 74 publications

References 11 publications

Cancer mortality among licensed herbicide applicators.

Cancer mortality among licensed herbicide applicators.

Development of models to predict dose of pesticides in professional turf applicators

Chronic toxicity of 2-methyl-4-chlorophenoxyacetic acid(MCPA) in mice.

Contact Info

Product

Resources

About