Mortality of workers employed at organochlorine pesticide manufacturing plants--an update.

Brown, David P.

doi:10.5271/sjweh.1593

Cited by 38 publications

(28 citation statements)

References 4 publications

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“…While a number of case-control studies examining pesticides observed elevated risks similar to our study [13,[43][44][45][46], other studies have not [47][48][49][50]. Certain types of pesticides seem to be more related to EPC than others.…”

Section: Discussionsupporting

confidence: 52%

Occupational exposures and risk of pancreatic cancer

et al. 2010

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The objective was to analyze the relationship between occupation (and specific occupational exposures) and risk of exocrine pancreatic cancer (EPC). We conducted a multicenter hospitalbased case-control study in Eastern Spain. We included 161 incident cases of EPC (59.6% men, 94 with histological confirmation, of whom 80% had ductal adenocarcinoma). Cases were frequency-matched with 455 controls by sex, age and province of residence. Information was elicited using structured questionnaires. Occupations were coded according to the Spanish version of the International Standard Classification of Occupations 1988. Occupational exposure to a selection of carcinogenic substances was assessed with the Finnish Job-Exposure Matrix (FINJEM). Odds ratios (OR) and 95% confidence intervals (CI) were estimated by multiple logistic regression, adjusting for sex, age, province, education, alcohol and smoking. A higher risk of EPC was associated with having worked as "Miners, shotfirers, stone cutters and carvers", "Machinery mechanics and fitters", "Building trades workers" and "Motor vehicle drivers" in men, "Office Clerks" in women, and "Waiters" in both sexes. Cases with ductal adenocarcinomas were more likely to have been exposed to chlorinated hydrocarbon solvents (OR = 4.1, 95% CI: 1.1-15.2, p-trend = 0.04). We also observed significant associations with exposure to "synthetic polymer dust exposure" and "ionizing radiation". Suggestive increases in risk were observed for "pesticides", "diesel and gasoline engine exhaust", and "hydrocarbon solvents". Results support the hypothesis that occupational exposure to chlorinated hydrocarbon solvents is associated with exocrine pancreatic cancer. 5

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Section: Discussionsupporting

confidence: 52%

Occupational exposures and risk of pancreatic cancer

et al. 2010

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“…[25][26][27] A study from Egypt reported that colorectal cancer patients had higher serum organochlorines levels than controls. 28 Other studies of farmers 29,30 and pesticide manufacturers, [31][32][33] however, did not show any excess risk of colorectal cancer.…”

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confidence: 99%

Pesticide use and colorectal cancer risk in the agricultural health study

Lee

Sandler

Blair

et al. 2007

Intl Journal of Cancer

121

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We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993)(1994)(1995)(1996)(1997). Cancer incidence was determined through populationbased cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend 5 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend 5 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. ' 2007 Wiley-Liss, Inc.

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“…Some occupational exposures with possible hormonal effect, such as exposure to pesticides and polychlorinated biphenyls (PCB), have been reported to increase the risk of hepatobiliary cancer among men (21)(22)(23). None of these studies, however, has been able to examine the risks for cancer of the extrahepatic and intrahepatic biliary tracts separately.…”

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confidence: 92%

Occupational exposure to endocrine-disrupting compounds and biliary tract cancer among men

Ahrens¹,

Mambetova²,

Bourdon-Raverdy³

et al. 2007

Scand J Work Environ Health

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Objectives This study investigated the association between cancer of the extrahepatic biliary tract and exposure to endocrine-disrupting compounds.Methods Altogether 183 men with histologically confirmed carcinoma of the extrahepatic biliary tract and 1938 matched controls were interviewed between 1995 and 1997 in the frame of an international multicenter case-control study in six European countries (Denmark, France, Germany, Italy, Spain, and Sweden). Selfreported job descriptions were converted to semiquantitative variables (intensity, probability, and duration of exposure) for 14 endocrine-disrupting compounds. The cases were compared with 1421 population controls and 517 colon adenocarcinoma patients. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained with unconditional logistic regression and adjusted for age, country, and gallstones.Results Occupational exposure to endocrine-disrupting compounds resulted in an OR of 1.4 (95% CI 1.0-2.1) with no dose-effect relationship for cumulative exposure (low: OR 1.3, 95% CI 0.6-3.0; medium: OR 1.5, 95% CI 0.8-2.7; high: OR 1.4, 95% CI 0.9-2.4) (only index participants). The elevated risk was restricted to extrahepatic bile ducts and ampulla Vateri (OR 1.7, 95% CI 1.0-2.6). The adjusted OR for cancer of the extrahepatic biliary tract after exposure to polychlorinated biphenyls was 2.8 (95% CI 1.3-5.9, only index participants). ConclusionsThe data show some associations between exposure to endocrine-disrupting compounds in the workplace and the risk for cancer of the extrahepatic biliary tract among men, particularly for the extrahepatic bile duct and ampulla of Vater. Polychlorinated biphenyls could possibly be a strong risk factor.Key terms epidemiology; carcinoma of the extrahepatic bile duct; case-control study; gallbladder carcinoma; xenoestrogen.

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Mortality of workers employed at organochlorine pesticide manufacturing plants--an update.

Cited by 38 publications

References 4 publications

Occupational exposures and risk of pancreatic cancer

Occupational exposures and risk of pancreatic cancer

Pesticide use and colorectal cancer risk in the agricultural health study

Occupational exposure to endocrine-disrupting compounds and biliary tract cancer among men

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