Mortality of first-time amputees in diabetics: A 10-year observation

Izumi, Yuki; Satterfield, Kathleen; Lee, Shuko; Harkless, Lawrence B.; Lavery, Lawrence A.

doi:10.1016/j.diabres.2008.09.005

Cited by 73 publications

(60 citation statements)

References 18 publications

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“…Other factors that have been found associated to mortality after amputations among people with diabetes in follow up studies include; higher age, cerebral vascular disease, coronary arterial disease, chronic kidney disease and dialysis [31][32][33].…”

Section: Discussionmentioning

confidence: 98%

“…Several studies have analyzed factor associated to mortality following lower extremity amputations [28][29][30][31][32][33]. In our country Aragon et al conducted a retrospective analysis of major lower extremity amputations among 221 patients with diabetes to assess predictors of in hospital mortality including clinical characteristic and laboratory test [28].…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, our study is subject to a series of limitations. Our data source was the CMBD, an administrative database that contains discharge data for hospitalizations in Spain and uses information the physician has included in the discharge report; therefore, it does not include all variables from the clinical history such as: chronic conditions, the duration of diabetes, complications, treatments or laboratory results factors that have been associated with mortality after LEA [28][29][30][31][32][33]. Another limitation of this database is its anonymity (no identifying items such as a clinical history number), which makes it impossible to detect whether the same patient was admitted more than once during the same year.…”

Section: Discussionmentioning

confidence: 99%

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National trends in incidence and outcomes in lower extremity amputations in people with and without diabetes in Spain, 2001–2012

López‐de‐Andrés

Jiménez-García

Aragón‐Sánchez

et al. 2015

Diabetes Research and Clinical Practice

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

National trends in incidence and outcomes in lower extremity amputations in people with and without diabetes in Spain, 2001–2012

López‐de‐Andrés

Jiménez-García

Aragón‐Sánchez

et al. 2015

Diabetes Research and Clinical Practice

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“…Altogether, acute myocardial infarction, heart failure, and sudden death represented 65% of allcause deaths in that cohort. This observation is in line with the concept that patients with ischemic diabetic foot have active arterial disease elsewhere in the body (4)(5)(6)(7)(8)(9)(10)(11). Therefore, predictors of residual risk of cardiovascular events are urgently needed.…”

Section: Discussionmentioning

confidence: 56%

Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia

et al. 2014

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OBJECTIVEPrediction of clinical outcome in diabetic patients with critical limb ischemia (CLI) is unsatisfactory. This prospective study investigates if the abundance and migratory activity of a subpopulation of circulating mononuclear cells, namely, CD45 dim CD34 pos CXCR4 pos KDR pos cells, predict major amputation and cardiovascular death in type 2 diabetic patients undergoing percutaneous transluminal angioplasty for CLI. RESEARCH DESIGN AND METHODSA consecutive series of 119 type 2 diabetic patients with CLI was enrolled. CD45 dim CD34 pos CXCR4 pos KDR pos cells were assessed by flow cytometry upon isolation and also after spontaneous or stromal cell-derived factor 1a2directed migration in an in vitro assay. The association between basal cell counts and migratory activity and the risk of an event at 18-month follow-up was evaluated in a multivariable regression analysis. Multivariable regression model analysis showed that cell migration forecasts cardiovascular mortality independently of other validated predictors, such as age, diagnosed coronary artery disease, serum C-reactive protein, and estimated glomerular filtration rate. In this model, doubling of migrated cell counts increases the cardiovascular death hazard by 100% (P < 0.0001). CONCLUSIONSThe new predictor could aid in the identification of high-risk patients with type 2 diabetes requiring special diagnostic and therapeutic care after revascularization.

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“…Indeed 10-30% of patients with DFUs progress to amputation within a period of 6-18 months after the first evaluation. Among amputated patients five years mortality is around 50-60% (10,11).…”

Section: Risk Factors and Pathogenesis Of Diabetic Foot Infectionsmentioning

confidence: 99%

Current Treatment of Diabetic Foot Infections and the Effect of Dermobor

Büke¹

2017

Cyprus J Med Sci

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One of the most serious chronic complications of diabetes is diabetic foot infections. Neuropathy, peripheral vascular disease and trauma are among the leading factors to development of diabetic foot ulcers and predispose to progress the diseases to diabetic foot infections. Delay of diagnosis and treatment and poor antibiotic treatment of diabetic foot infections can result in amputation. Diabetic foot ulcers and infections are the main causes of foot amputation around the world. The five-year survival rate of patients underwent foot amputation due to diabetic foot infections is low. With this review it's aimed to give information about the current epidemiology, risk factors, diagnosis and antimicrobial therapy of diabetic foot infections. In addition it's intended to give the results of Dermobor treatment in small number of cases with diabetic foot ulcers and infections.

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Mortality of first-time amputees in diabetics: A 10-year observation

Cited by 73 publications

References 18 publications

National trends in incidence and outcomes in lower extremity amputations in people with and without diabetes in Spain, 2001–2012

National trends in incidence and outcomes in lower extremity amputations in people with and without diabetes in Spain, 2001–2012

Migratory Activity of Circulating Mononuclear Cells Is Associated With Cardiovascular Mortality in Type 2 Diabetic Patients With Critical Limb Ischemia

Current Treatment of Diabetic Foot Infections and the Effect of Dermobor

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