Mortality of Alzheimer’s Disease Patients: A 10-Year Follow-up Pilot Study in Shanghai

Zhang, Yueqi; Wang, Chunfang; Xu, Gang; Zhao, Qianhua; Xie, Xinyi; Cui, Hai-lun; Wang, Ying; Ren, Rong; Guo, Qihao; Wang, Gang

doi:10.1017/cjn.2019.333

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…Interestingly, a pilot study in Shanghai using hospital-based samples reported a similar survival trend of patients with AD compared with that of the general population. Poor cognitive status and comorbid diabetes had a negative impact on the survival of patients with AD,4 and a noteworthy association between AD and specific types of cancer was observed in China 16…”

Section: Data Source and Analysismentioning

confidence: 99%

“…Compared with the 2010 census figures, China’s ageing population grew faster, and the incidence rate, morbidity and mortality of diseases associated with ageing were significantly higher 2. Alzheimer’s disease (AD) incidence continues to increase, and its social and economic burden is magnifying, posing major medical and social problems that threaten China’s urban and rural residents 3 4. According to a recent national cross-sectional study, China has 15.07 million individuals aged 60 years and over with dementia, including 9.83 million with AD, 3.92 million with vascular dementia and 1.32 million with other forms of dementia.…”

Section: Introductionmentioning

confidence: 99%

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The China Alzheimer Report 2022

et al. 2022

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China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated, especially Alzheimer’s disease (AD) and related dementias (ADRD). AD’s incidence rate, morbidity, and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals, families and society. The ‘Healthy China Action’ plan of 2019–2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD. This report describes related epidemiological trends, evaluates the economic burden of the disease, outlines current clinical diagnosis and treatment status and delineates existing available public health resources. More specifically, it examines the public health impact of ADRD, including prevalence, mortality, costs, usage of care, and the overall effect on caregivers and society. In addition, this special report presents technical guidance and supports for the prevention and treatment of AD, provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.

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Section: Data Source and Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The China Alzheimer Report 2022

et al. 2022

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“…Consistent with previous studies, diabetes was associated with a high risk of death in patients with dementia. [ 55 , 56 ] Both AD and diabetes are chronic diseases that may share common pathologic features, [ 57 ] and there is increasing evidence of brain glucose dysregulation in AD. This may also be related to a faster annual rate of cognitive decline in AD patients, [ 58 ] and diabetes seems to promote specific neuropathologic processes that contribute to dementia.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for in-hospital death in elderly patients over 65 years of age with dementia: A retrospective cross-sectional study

Meng

Cheng

et al. 2022

Medicine

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As the population continues to age, dementia is becoming a huge social, economic, and healthcare burden. However, the risk factors for in-hospital death in elderly patients over 65 years of age with dementia are not well understood. Identifying factors that affect their prognosis could help clinicians with scientific decision-making. To examine the risk factors for in-hospital death in elderly patients over 65 years of age with dementia in the Geriatric Department of West China Hospital. In this retrospective, cross-sectional study, we analyzed inpatients aged ≥65 years with dementia between 2010 and 2016 using electronic medical records from the Information Center of West China Hospital. The risk factors for death were assessed using multivariable logistic regression. Out of a total of 2986 inpatients with dementia, 3.4% died. Patient deaths were related to digestive diseases, respiratory diseases, circulatory diseases, urinary diseases, and chronic obstructive pulmonary disease, whereas patient survival was associated with osteoporosis and Parkinson disease. Patients with a mean length of hospital stay of ≥60 days had an increased risk of death (all P <.05). In the multiple logistic regression analysis, age ≥80 years, digestive diseases, respiratory diseases, urinary diseases, diabetes, chronic obstructive pulmonary disease, and ≥7 comorbidities were risk factors for death. Mortality in hospitalized older patients with dementia is low, but some risk factors may be easily ignored. These findings could raise awareness among clinicians and caregivers about risk factors in hospitalized older patients, particularly hospitalized elderly patients with multiple comorbidities. Therefore, to reduce mortality, early prevention and management of potential risks are necessary.

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“…49 From one existing pilot study in China, patients with AD have a similar survival trend compared to the general population during 10-year follow-up. 50 and it remains an open question how to appropriately adjust findings for the uncertain differential competing risk from death in AD and non-AD individuals of the cohort. Second, considering the chief complaint of memory loss for most individuals during their first visit to clinicians, the elderly do not always seek medical service due to a lack of early definitive symptoms and due to stigmatization of the AD diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…First, the death from a chronic disease like AD is hard to determine, as most are recorded as hypostatic pneumonia, cachexia, or other complications using the ICD‐10 code 49 . From one existing pilot study in China, patients with AD have a similar survival trend compared to the general population during 10‐year follow‐up 50 . and it remains an open question how to appropriately adjust findings for the uncertain differential competing risk from death in AD and non‐AD individuals of the cohort.…”

Section: Discussionmentioning

confidence: 99%