Mortality in the Sheep Ked, Melophagus ovinus (L.), caused by Trypanosoma melophagium Flu.

Wa, Nelson

doi:10.1038/178750b0

Cited by 11 publications

(2 citation statements)

References 2 publications

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“…Nonetheless, some studies highlighted the effect of Trypanosoma infections on the condition and survivability of the invertebrate host. Nelson (1956) reports high mortality of sheep keds, caused by obstruction of the intestine with a massive number of trypanosomes. However, Hoare (1972) did not notice any changes in the appearance and behaviour of sheep ticks in his research.…”

Section: Introductionmentioning

confidence: 99%

Molecular detection of Trypanosoma spp. in Lipoptena cervi and Lipoptena fortisetosa (Diptera: Hippoboscidae) and their potential role in the transmission of pathogens

et al. 2020

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The family Hippoboscidae is a less known group of blood-sucking flies. Deer ked are particularly important for animal health; they may act as potential vectors of disease to ungulates, and may transmit pathogens to animals and humans. The aim of this study was to investigate the presence of Trypanosoma (Megatrypanum) DNA in deer keds using molecular methods. Results prove the presence of Megatrypanum trypanosome DNA in the studied winged adult deer keds and this is the first detection of this pathogen in Lipoptena fortisetosa. In addition, this paper evidences the occurrence of L. fortisetosa in two new locations: one in the Białowieża Primeval Forest, and another in the Strzałowo Forest Inspectorate (Piska Forest), both in north-eastern Poland.

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Section: Introductionmentioning

confidence: 99%

Molecular detection of Trypanosoma spp. in Lipoptena cervi and Lipoptena fortisetosa (Diptera: Hippoboscidae) and their potential role in the transmission of pathogens

et al. 2020

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“…It mainly occurs in sheep, dogs, horses, etc., resulting in animal emaciation, anemia, poor growth, decreased quality of livestock products, and even death of individual animal pups. Besides, the most serious harm of Melophagus ovinus is that it can be used as a vector to spread bluetongue virus ( 1 ), Trypanosoma ( 2 ), Bartonella ( 3 ), Rickettsia ( 4 ), Acinetobacter ( 5 ), and other pathogens. Among them, bluetongue is one of the most susceptible sheep infectious diseases, with an incidence rate of 76% ( 6 ), causing great harm to animal husbandry.…”

Section: Introductionmentioning

confidence: 99%

Tandem mass tag labeled quantitative proteomic analysis of differential protein expression on total alkaloid of Aconitum flavum Hand.-Mazz. against melophagus ovinus

et al. 2022

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Melophagus ovinus disease is a common ectoparasitosis, which can lead to a decrease in animal production performance, product quality, and even death. Aconitum flavum Hand.-Mazz. has many pharmacological activities including insecticidal, heat-clearing, analgesic, and dehumidifying. However, there are few researches focused on the effects and related mechanism of Aconitum flavum Hand.-Mazz. in killing Melophagus ovinus. In this study, 11 alkaloids of Aconitum flavum Hand.-Mazz. were detected, and its total alkaloid activity was determined. The results showed when the total alkaloid concentration was 64 mg/ml and the treatment time was 16 h, the killing rate of Melophagus ovinus reached 100%. Through the observation of the differences in the surface of Melophagus ovinus in each experimental group, it was found that the morphology of the posterior end of the female Melophagus ovinus in the alkaloid treatment group was significantly different from that of the blank and positive control groups, and most of the epidermal tissue was obsessive and missing. Moreover, the enzyme activity determination results of 64 mg/ml group were significantly different when compared with the normal control group, while there was no significant difference in other groups. Then, the Melophagus ovinus gene library was established by the unreferenced genome transcriptome sequencing, the proteomic comparison was performed using tandem mass tag labeled protein detection technology, and finally, the samples were quantitatively analyzed by liquid chromatography-mass spectrometry tandem and bioinformatics methods. Based on the above experimental results, it was speculated that Aconitum flavum Hand.-Mazz. total alkaloids may cause the imbalance of protein disulfide isomerase expressions by affecting the regulation of Hsp40 cellular protein homeostasis and the oxidation of protein disulfide isomerase and related proteins. This would affect the selective recognition of signal sequence, the targeted transport of Sec 61, and the correct folding of the three-dimensional structure of amino acid chain, weakening the clearance of amino acid chains that cannot be correctly folded and eventually resulting in the killing of Melophagus ovinus. This study preliminarily revealed the mechanism of Aconitum flavum Hand.-Mazz. total alkaloids against Melophagus ovinus and provided a theoretical basis for the screening of Melophagus ovinus action targets and the development of new veterinary drugs.

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Melophagus ovinus (Pupipara: Hippoboscidae): Confirmation of the nonpathogenicity of Trypanosoma melophagium for sheep keds

Nelson¹

1981

Journal of Invertebrate Pathology

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Mortality in the Sheep Ked, Melophagus ovinus (L.), caused by Trypanosoma melophagium Flu.

Cited by 11 publications

References 2 publications

Molecular detection of Trypanosoma spp. in Lipoptena cervi and Lipoptena fortisetosa (Diptera: Hippoboscidae) and their potential role in the transmission of pathogens

Molecular detection of Trypanosoma spp. in Lipoptena cervi and Lipoptena fortisetosa (Diptera: Hippoboscidae) and their potential role in the transmission of pathogens

Tandem mass tag labeled quantitative proteomic analysis of differential protein expression on total alkaloid of Aconitum flavum Hand.-Mazz. against melophagus ovinus

Melophagus ovinus (Pupipara: Hippoboscidae): Confirmation of the nonpathogenicity of Trypanosoma melophagium for sheep keds

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