Mortality in paediatric burns victims: A retrospective review from 2009 to 2012 in a single centre

Jugmohan, Ben; Loveland, Jerome; Doedens, L.; Moore, Rachel; Welthagen, Ansie; Westgarth-Taylor, Christopher

doi:10.7196/samj.2016.v106i2.8942

Cited by 10 publications

(13 citation statements)

References 11 publications

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“…Of the 66 children analysed, the majority were male (55%) which is similar to previous burns studies done by Jugmohan et al ( 2016 ) and Albertyn, Bickler and Rode ( 2006 ) which reported that males more commonly had burn injuries. Three similarities and trends were noted between the five children who developed the contractures; these were of the male gender, the injury was as a result of flame burns and was a full-thickness burn depth injury.…”

Section: Discussionsupporting

confidence: 87%

The use of Xbox Kinect™ in a Paediatric Burns Unit

Lozano

Potterton

2018

S. Afr. j. physiother.

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BackgroundThe popularity of video game use in burns rehabilitation has grown because, in addition to facilitating maintenance of range of motion (ROM), the virtual imaging characteristics of these games provide distraction from pain.ObjectivesThe effect of using Xbox Kinect™ as an adjunct to physiotherapy in a Paediatric Burns Unit (PBU) has not been established. This study aimed to investigate the effect of using the Xbox Kinect™ on outcomes of children in the PBU at Chris Hani Baragwanath Academic Hospital.MethodsThis non-equivalent, post-test only control group study took place over a period of 14 months. The control group received standard physiotherapy management and the experimental group received standard physiotherapy management and additional Xbox Kinect™. Outcome measures were ROM, Activities Scale for Kids (ASK©p) and a modified Wong-Baker FACES® enjoyment rating scale. Outcomes were assessed at discharge and then 1 week post-discharge at the usual follow-up appointment.ResultsSixty-six children participated in this study. More than 50% of the burns were because of hot water, followed by flame burns (30%) and electrical burns (12%). The addition of Xbox Kinect™ was effective in achieving higher active ROM (AROM) between discharge and follow-up (p < 0.01). Fun and enjoyment (p < 0.01) was found to be significantly higher in the children who participated in Xbox Kinect™. Total body surface area (TBSA%) (p = 0.03), age (p = 0.05) and AROM (p = 0.04) were significantly associated with ASK©p scores.ConclusionThe use of the Xbox Kinect™ has been shown to be a beneficial and useful adjunct to burns rehabilitation in this paediatric burns population.Clinical implicationsCurrently, there is limited information and research on interventions for children with burns in South Africa. The addition of Xbox Kinect™ to standard physiotherapy in-patient care was both enjoyable and effective and should be considered where funding is available.

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Section: Discussionsupporting

confidence: 87%

The use of Xbox Kinect™ in a Paediatric Burns Unit

Lozano

Potterton

2018

S. Afr. j. physiother.

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“…Accordingly, some studies have shown that light reduces the concentration of pyocyanin in P. aeruginosa and that this effect was dependent on light intensity and wavelength (48). It has also been shown that high doses of blue light treatment inhibited the activity of pyocyanin, staphylolysin, pseudolysin and other proteases (37, 39). Furthermore, it has been demonstrated that pyocyanin confers on P. aeruginosa resistance to ionic silver (49).…”

Section: Resultsmentioning

confidence: 99%

“…In fact, owe to its outer membrane low permeability, expression of efflux pumps, and biofilm formation, P. aeruginosa is one of the most difficult organisms to treat with antibiotics. Skin infections by P. aeruginosa on burn victims are particularly problematic, in part due to non-efficient treatments (35–37). The World Health Organization (WHO) included carbapenem resistant P. aeruginosa in a list of critical priority bacteria to which the research and development of new antibiotics and alternative treatments is of paramount importance (38).…”

Section: Introductionmentioning

confidence: 99%

Visible Light Plasmon Excitation of Silver Nanoparticles Against Antibiotic-ResistantPseudomonas aeruginosa

Silva

Petri

Valencia

et al. 2020

Preprint

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17The interaction of metallic nanoparticles with light excites a local surface plasmon resonance 18 (LSPR). This phenomenon enables the transfer of hot electrons to substrates that release 19 Reactive Oxygen Species (ROS). In this context, the present study was aimed at enhancing 20 the antibacterial effect of citrate-covered silver nanoparticles (AgNPs), which already possess 21 excellent antimicrobial properties, via LSPR excitation with visible LED 22 against Pseudomonas aeruginosa, one of the most refractory organisms to antibiotic 23 treatment. The Minimum Inhibitory Concentration (MIC) of AgNPs was 10 μg/ml under dark 24 conditions and 5 μg/ml under light conditions. The combination of light and AgNPs led to 25 100% cell death after 60 minutes. Quantification of ROS via flow cytometry showed that 26 LSPR stimulated AgNPs increased intracellular ROS concentration by 4.8-fold, suggesting 27 that light-exposed AgNPs caused cell death via ROS production. Light exposition caused a 28 small release of silver ions (0.4%) reaching a maximum after 6 hours. This indicates that 29 silver ions play at most a secondary role in P. aeruginosa death. Overall, the results presented 30 here show that LSPR generation from AgNPs by visible light enhances the antimicrobial 31 activity of silver nanoparticles and can be an alternative for the treatment of topic infections 32 caused by antibiotic-resistant bacteria such as P. aeruginosa. 33 34 36 37 Running title: Light-enhanced Ag nanoparticles against P. aeruginosa 38 39 40 42 ability of fine tuning their composition, structure and shape (1). The desired electronic, 43 optical and chemical properties of nanoparticles can be obtained through modern synthetic 44 techniques devised in the past decades (2). Even small variations in one of these parameters 45 may result in new properties that are absent in the analogous bulk material. Due to its high 46 range of controllable features, metallic nanoparticles are now used in many processes, such as 47 48others. 49Silver nanoparticles (AgNPs)(2), exhibit a great potential of use in many areas, due to their 50 relative easy and controlled synthesis (8), ranging from small and simple spheroidal AgNPs 51 (9) to more complex geometries (10, 11) and even asymmetric shapes (12-14) with solid or 52 hollow interiors (15-17). Historrically, silver has been extensively used as an antimicrobial 53 agent. Many different commercial products relying on silver biocidal properties have been 54 produced, most of them in the last 10 years (18, 19). The wide variety of AgNPs as well as 55 the intrinsic properties of metallic silver in relation to biological system and biomolecules 56 (20) fostered the extensive use of AgNPs in medical applications, such as cancer treatment 57 (21-23), drug delivery (24, 25), imaging (26, 27) and antimicrobial treatment (28, 29). 58 P. aeruginosa is a ubiquitous Gram-negative γ-proteobacterium and an opportunistic 59 pathogen associated with nosocomial infections. It also affects patients afflicted by chronic 60 res...

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“…Since 2009, this dedicated burns unit has run a programme in which intensivists and a dedicated burns surgeon are part of the multidisciplinary management team. The experience of this specialised unit is described by Jugmohan et al [15] ('Mortality in paediatric burns victims: A retrospective review from 2009 to 2012 in a single centre'). The vast majority of admissions (76.5%) were a consequence of hot-water burns, with flame burns the second leading cause (21.8%).…”

Section: Paediatric Burn Injuriesmentioning

confidence: 99%

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2016

S Afr Med J

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Mortality in paediatric burns victims: A retrospective review from 2009 to 2012 in a single centre

Cited by 10 publications

References 11 publications

The use of Xbox Kinect™ in a Paediatric Burns Unit

The use of Xbox Kinect™ in a Paediatric Burns Unit

Visible Light Plasmon Excitation of Silver Nanoparticles Against Antibiotic-ResistantPseudomonas aeruginosa

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