Mortality in Older Patients with COVID‐19

Zhao, Hai Lu; Huang, Yan; Huang, Yi

doi:10.1111/jgs.16649

Cited by 24 publications

(30 citation statements)

References 9 publications

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“…Current literature suggests an association between obesity and increased mortality in patients with COVID-19 pneumonia in the general population, especially in younger patients [7][8][9]. Baseline characteristics such as obesity, belonging to a minority population, older age, male gender, and comorbidities such as hypertension and diabetes have been described as risk factors for a poor prognosis [4,7,[10][11][12].…”

Section: Discussionmentioning

confidence: 99%

The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

Nyabera¹,

Lakhdar²,

Li³

et al. 2020

Cureus

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Background and aim Coronavirus disease 2019 (COVID-19) is known to cause a broad spectrum of illnesses. There is evidence that obesity-related conditions may increase the severity of COVID-19 disease, especially in those below the age of 60. However, there has been limited research on mortality rate based on body mass index (BMI) in the older adult population, defined as age over 65. The objective of this study was to characterize outcomes in older adults infected with COVID-19 based on BMI. Study design and methods It is a single-center retrospective cohort study of older adults with COVID-19 infection. The primary outcome was hospital mortality. Secondary outcomes assessed were oxygen requirements, need for mechanical ventilation, duration of mechanical ventilation, and hospital length of stay. Data were analyzed with the Student's t-test, Fisher's exact test, and multiple logistic regression analyses as appropriate. Results A total of 290 patients were included in this study. The mean age was 77.6 years. The median BMI was >30 kg/m2. The primary outcome of hospital mortality occurred in 49.7% of patients. BMI was not found to be a predictor of mortality. Age 75-79 and age ≥ 85 were associated with an increased risk of mortality (

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Section: Discussionmentioning

confidence: 99%

The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

Nyabera¹,

Lakhdar²,

Li³

et al. 2020

Cureus

View full text Add to dashboard Cite

show abstract

“…The disease was detected in the United States on January 20, 2020, and had caused >1.7 million cases and >100,000 deaths as of June 1, 2020 (1,2). As the pandemic continues, data consistently show that older adults, particularly those with >1 underlying medical conditions, experience higher hospitalization rates and increased vulnerability to in-hospital death (3,4).…”

Section: Dispatchesmentioning

confidence: 99%

“…Long-term care facilities (LTCFs) in the United States, including skilled nursing facilities (SNFs) and assisted living facilities (ALFs), are populated by older adults and adults needing residential care for underlying medical conditions who are at increased risk of more severe COVID-19-associated illness (4,5). ALF residents generally require a limited amount of care, such as help getting dressed or assistance with medications, whereas SNF residents have acute or chronic health conditions, or both, that require 24hour onsite medical care and often rehabilitative care and therapy.…”

Section: Dispatchesmentioning

confidence: 99%

High Proportion of Asymptomatic SARS-CoV-2 Infections in 9 Long-Term Care Facilities, Pasadena, California, USA, April 2020

Feaster¹,

Goh²

2020

Emerg. Infect. Dis.

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“…Age, unlike in the younger population (2,6,18,19), did not bring an added risk in any of the models built here, and male sex was a predictor of severe disease but not mortality. The trials by Gutiérrez-Rodríguez et al (11) and Covino et al (10) did not nd that age or sex were predictors of mortality either.…”

Section: Predictors Of Severe Disease and Mortalitymentioning

confidence: 62%

Covid-19 in the Oldest-old Population (80 and Older): Clinical Presentation and Prognostic Factors of Severe Disease and Mortality. A Cohort Study.

Gálvez‐Barrón

Arroyo-Huidobro

Miñarro

et al. 2020

Preprint

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BACKGROUND The oldest-old population (80 years or older) has the highest lethality from COVID-19. There is little information on the clinical presentation and specific prognostic factors for this group. This trial evaluated the clinical presentation and prognostic factors of severe disease and mortality in the oldest-old population.METHODS Ambispective cohort study of oldest-old patients hospitalized for respiratory infection associated with COVID-19 and with a positive test by real-time polymerase chain reaction. The clinical presentation and the factors associated with severe disease and mortality were evaluated (logistic regression). All patients were followed until discharge or death.RESULTS A total of 103 patients (59.2% female) were included. The most frequent symptoms were fever (68.9%), dyspnoea (60.2%), and cough (39.8%), and 11.7% presented confusion. Fifty-nine patients (57.3%) presented severe disease, and 59 died, with 43 patients (41.7%) presenting both of these. In the multivariate analysis, male sex (OR 0.31, 95% confidence interval [95% CI] 0.13-0.73, p 0.0074) and serum lactate dehydrogenase (LDH) (OR 2.55, 95% CI 1.21-5.37, p 0.0139) were associated with severe disease, and serum sodium was associated with mortality (OR 3.12, 95% CI 1.18-8.26, p 0.0222). No chronic disease or pharmacological treatment were associated with worse outcomes.CONCLUSIONS The typical presenting symptoms of respiratory infection in COVID-19 are less frequent in the oldest-old population. Male sex and LDH level are predictors of severe disease, and serum sodium level predicts of mortality in this population.

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Mortality in Older Patients with COVID‐19

Cited by 24 publications

References 9 publications

The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

The Association Between BMI and Inpatient Mortality Outcomes in Older Adults With COVID-19

High Proportion of Asymptomatic SARS-CoV-2 Infections in 9 Long-Term Care Facilities, Pasadena, California, USA, April 2020

Covid-19 in the Oldest-old Population (80 and Older): Clinical Presentation and Prognostic Factors of Severe Disease and Mortality. A Cohort Study.

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