Mortality in a cohort of diabetic patients

Waugh, Norman; Dallas, Jean; Jung, R. T.; Newton, R. W.

doi:10.1007/bf00505181

Cited by 53 publications

(47 citation statements)

References 7 publications

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“…Better sensitivity was reported in studies with smaller (n ϭ Ͻ550) sample sizes (4,14,16,19,20,24,27,28,31) and limited to patients with diabetes (4,14,16,19,31). Studies outside the U.S. tended to report higher sensitivity (51-70%), but differences in diabetes diagnostic criteria and procedures for completion of death certificates make comparisons difficult (13,14,16,28,31,33,34).…”

Section: Discussionmentioning

confidence: 96%

“…The few previous longitudinal studies of diabetes reporting on death certificates were conducted in foreign countries, making comparisons with U.S. data difficult (13)(14)(15)(16), were based on data collected before 1994 (17,18), or were from diabetic populations only (4). In these studies the correct reporting of diabetes on death certificates ranged from 35 to 65%.…”

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confidence: 99%

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Sensitivity and Specificity of Death Certificates for Diabetes

et al. 2008

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OBJECTIVE -Diabetes is the sixth leading cause of death in U.S adults, which may be an underestimate because of under-reporting on death certificates. In this study we examined death certificate sensitivity and specificity for diabetes, as well as the factors related to better reporting, in a community-based sample.RESEARCH DESIGN AND METHODS -Death certificates were obtained for 3,209 decedents who were enrolled in the Rancho Bernardo cohort in 1972-1974 and followed through 2003. Diabetes status was reassessed at periodic clinic visits and annual mailed surveys during an average follow-up of 15.2 Ϯ 7.6 years. Diabetes reported anywhere on death certificates was abstracted. Sensitivity and specificity calculations among diabetic participants were stratified by age, sex, year, place, cause of death, and diabetes medication use.RESULTS -Among 1,641 men and 1,568 women, 378 decedents had a history of diabetes, 168 of whom had diabetes listed anywhere on their death certificates. The sensitivity and specificity were 34.7 and 98.1%. Diabetes reporting on death certificates did not improve over time or vary significantly by age and sex, but sensitivity for diabetes reporting was better for recent (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003) cardiovascular disease (CVD) deaths compared with any other causes of death (48.9 vs. 28.6%, respectively, P Ͻ 0.05).CONCLUSIONS -Although diabetes reporting on death certificates did not improve over time, sensitivity was better for diabetes in the context of CVD deaths, probably reflecting the increasing recognition that diabetes is a major cardiovascular risk factor. Diabetes Care 31:279-284, 2008

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Section: Discussionmentioning

confidence: 96%

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confidence: 99%

Sensitivity and Specificity of Death Certificates for Diabetes

et al. 2008

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“…Other limitations of this study are the under-recording of diabetes. Regarding the declaration of diabetes in health interview surveys, some studies have concluded that educational differences in misreporting of diabetes are small or absent [25]. Moreover, health surveys of diabetes only report diagnosed diabetes, which only represents between 30% and 50% of total diabetes [26,27].…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic inequalities in diabetes mellitus across Europe at the beginning of the 21st century

et al. 2008

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Aims/hypothesis The aim of this study was to determine and quantify socioeconomic position (SEP) inequalities in diabetes mellitus in different areas of Europe, at the turn of the century, for men and women. Methods We analysed data from ten representative national health surveys and 13 mortality registers. For national health surveys the dependent variable was the presence of diabetes by self-report and for mortality registers it was death from diabetes. Educational level (SEP), age and sex were independent variables, and age-adjusted prevalence ratios (PRs) and risk ratios (RRs) were calculated. ResultsIn the overall study population, low SEP was related to a higher prevalence of diabetes, for example men who attained a level of education equivalent to lower secondary school or less had a PR of 1.6 (95% CI 1.4-1.9) compared with those who attained tertiary level education, whereas the corresponding value in women was 2.2 (95% CI 1.9-2.7). Moreover, in all countries, having a disadvantaged SEP is related to a higher rate of mortality from diabetes and a linear relationship is observed. Eastern European countries have higher relative inequalities in mortality by SEP. According to our data, the RR of dying from diabetes for women with low a SEP Diabetologia (2008) 51:1971-1979 DOI 10.1007/s00125-008-1146 3.4 (95% CI 2.6-4.6), while in men it is 2.0 (95% CI 1.7-2.4). Conclusions/interpretation In Europe, educational attainment and diabetes are inversely related, in terms of both morbidity and mortality rates. This underlines the importance of targeting interventions towards low SEP groups. Access and use of healthcare services by people with diabetes also need to be improved.

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“…HTN is a major cause of mortality in both type 1 and type 2 diabetics [37,38]. The prevalence of HTN appears to be about 2-folds more in patients with diabetes in contrast to non-diabetic patients, with this relationship being clearer in type 1 DM [39].…”

Section: Hypertensionmentioning

confidence: 99%

Predictors of diabetic nephropathy

Gaballa

Farag

2013

Open Medicine

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AbstractDiabetic nephropathy (DN) is a leading cause of morbidity and mortality in diabetic patients representing a huge health and economic burden. Alarming recent data described diabetes as an unprecedented worldwide epidemic, with a prevalence of ∼6.4% of the world population in 2010, while the prevalence of CKD among diabetics was approximately 40%. With a clinical field hungry for novel markers predicting DN, several clinical and laboratory markers were identified lately with the promise of reliable DN prediction. Among those are age, gender, hypertension, smoking, sex hormones and anemia. In addition, eccentric left ventricular geometric patterns, detected by echocardiography, and renal hypertrophy, revealed by ultrasonography, are promising new markers predicting DN development. Serum and urinary markers are still invaluable elements, including serum uric acid, microalbuminuria, macroalbuminuria, urinary liver-type fatty acid-binding protein (u-LFABP), and urinary nephrin. Moreover, studies have illustrated a tight relationship between obstructive sleep apnea and the development of DN. The purpose of this review is to present the latest advances in identifying promising predictors to DN, which will help guide the future research questions in this field. Aiming at limiting this paramount threat, further efforts are necessary to identify and control independent modifiable risk factors, while developing an integrative algorithm for utilization in DN future screening programs.

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Mortality in a cohort of diabetic patients

Cited by 53 publications

References 7 publications

Sensitivity and Specificity of Death Certificates for Diabetes

Sensitivity and Specificity of Death Certificates for Diabetes

Socioeconomic inequalities in diabetes mellitus across Europe at the beginning of the 21st century

Predictors of diabetic nephropathy

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