Mortality from thyroid cancer in patients with hyperthyroidism: the Theagenion Cancer Hospital experience

Abstract

Background: Thyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroidism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece. Patients: Among 720 patients treated for thyroid cancer, 60 had a concomitant diagnosis of hyperthyroidism due to Graves' disease (nZ14), solitary autonomous adenoma (nZ17), or multinodular goiter (nZ29). Adverse prognostic factors were common in patients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hyperthyroidism and cases where tumor size was more than 10 mm. Results: In 10 out of 17 patients with hyperthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy. Conclusion: Clinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this patient group.

Cancer risk in patients hospitalised for Graves’ disease: a population-based cohort study in Sweden

“…For thyroid cancer, previous studies have reported inconsistent results (Cole, 1991;Majima et al, 2005;Pazaitou-Panayiotou et al, 2008). We found increased risks, confined to the early overall Cancer risk after Graves' disease X Shu et al follow-up period, though for men the risk was noted even for the All1 þ period.…”

“…Inconsistent associations between GD and malignant tumours have been reported (Cristofanilli et al, 2005;Majima et al, 2005;Pazaitou-Panayiotou et al, 2008). Small study size and variable case reporting weaken the generalisability of the results (Majima et al, 2005;Pazaitou-Panayiotou et al, 2008). In our cohort study, the largest to date, 18 156 hospitalised GD patients were studied to quantify their subsequent cancer risk.…”

Thyroid Cancer in Patients with Hyperthyroidism

“…In many cases thyroid cancer is not known preoperatively, but is found incidentally during postoperative histologic examination of the thyroid [ 33 ] . We previously reported a study of 60 hyperthyroid patients diagnosed with thyroid cancer [ 11 ] . Among those patients, only 12 were operated for suspicion of thyroid cancer preoperatively, whereas in the remaining 48, in whom the indication for thyroidectomy was treatment for thyrotoxicosis, thyroid cancer was incidentally found after surgery.…”

Follicular Variant of Papillary Thyroid Carcinoma Presenting as Toxic Nodule in an Adolescent: Coexistent Polymorphism of the TSHR and Gsα Genes

“…Consequently, FNAB is not recommended (4). Nevertheless, malignancy may be found in AFTNs with non-negligible frequency in both adults and children (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”