Mortality From Lymphohematopoietic Malignancies Among Workers in Formaldehyde Industries: The National Cancer Institute Cohort

Freeman, Laura E. Beane; Blair, Aaron; Lubin, Jay H.; Stewart, Patricia A.; Hayes, Richard B.; Hoover, Robert N.; Hauptmann, Michael

doi:10.1093/jnci/djp096

Cited by 200 publications

(273 citation statements)

References 29 publications

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“…However, whether or not inhaled formaldehyde exposure causes leukemia remains debatable. Previous experimental results have not supported the induction of leukemia (Lu et al, 2010a), and epidemiological reports have been inconsistent across different studies (Beane Freeman et al, 2009;Coggon et al, 2014). K.J.…”

mentioning

confidence: 99%

“…The carcinogenic mode of action is based on the synergism among the formation of DNA mono-adducts, DPCs, and increased cell proliferation that lead to mutations (International Agency for Research on Cancer, 2006). Epidemiologic associations have been reported between formaldehyde exposure and the induction of leukemia (Beane Freeman et al, 2009). However, whether or not inhaled formaldehyde exposure causes leukemia remains debatable.…”

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confidence: 99%

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Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

Yu¹,

Lai²,

Hartwell³

et al. 2015

Toxicol. Sci.

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Formaldehyde is not only a widely used chemical with well-known carcinogenicity but is also a normal metabolite of living cells. It thus poses unique challenges for understanding risks associated with exposure. N 2-hydroxymethyl-dG (N 2 -HOMedG) is the main formaldehyde-induced DNA mono-adduct, which together with DNA-protein crosslinks (DPCs) and toxicityinduced cell proliferation, play important roles in a mutagenic mode of action for cancer. In this study, N 2 -HOMe-dG was shown to be an excellent biomarker for direct adduction of formaldehyde to DNA and the hydrolysis of DPCs. The use of inhaled [ 13 CD 2 ]-formaldehyde exposures of rats and primates coupled with ultrasensitive nano ultra performance liquid chromatography-tandem mass spectrometry permitted accurate determinations of endogenous and exogenous formaldehyde DNA damage. The results show that inhaled formaldehyde only reached rat and monkey noses, but not tissues distant to the site of initial contact. The amounts of exogenous adducts were remarkably lower than those of endogenous adducts in exposed nasal epithelium. Moreover, exogenous adducts accumulated in rat nasal epithelium over the 28-days exposure to reach steady-state concentrations, followed by elimination with a half-life (t 1/2 ) of 7.1 days. Additionally, we examined artifact formation during DNA preparation to ensure the accuracy of nonlabeled N 2 -HOMe-dG measurements. These novel findings provide critical new data for understanding major issues identified by the National Research Council Review of the 2010 Environmental Protection Agency's Draft Integrated Risk Information System Formaldehyde Risk Assessment. They support a data-driven need for reflection on whether risks have been overestimated for inhaled formaldehyde, whereas underappreciating endogenous formaldehyde as the primary source of exposure that results in bone marrow toxicity and leukemia in susceptible humans and rodents deficient in DNA repair.

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mentioning

confidence: 99%

mentioning

confidence: 99%

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

Yu¹,

Lai²,

Hartwell³

et al. 2015

Toxicol. Sci.

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“…Exposure to extremely high concentrations of HCHO in air can produce spasms and edema of the larynx. Individual susceptibility to the irritating effects of airborne formaldehyde can increase with repeated exposures [5,6].…”

Section: Introductionmentioning

confidence: 99%

Preformed Amide-containing biopolymer for Improving the Environmental Performance of Synthesized Urea–formaldehyde in Agro-fiber Composites

et al. 2011

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Investigations have continued for production high performance agro-based composites using environmentally acceptable approaches. This study examines the role of adding amide-containing biopolymers during synthesis of urea-formaldehyde (UF) on properties of adhesive produced, especially its adhesion potential. The environmental performance of UF-resin synthesized in the presence of modified amide-containing biopolymer was evaluated by evaluating the free-HCHO of both adhesive (during processing) and of the eventual engineered composite product. Also, the benefits of this synthesis-modified adhesive in enhancing the bondability of sugar-cane fibers used in engineered composite panels was evaluated and compared to using UF-resin. The results obtained show that, static bending of the produced composites varied from 27.7 to 33.13 N/mm 2 of modulus of rupture (MOR) and from 2860 to 3374 N/mm 2 of Modulus of Elasticity (MOE); while for internal bond (IB) it's varied from 0.64 to 0.866 N/mm 2 . Based on the ANSI and EN Standards modified UF-based agro composites produced meet the performance requirements for high grade particleboards with respect to static bending strength. These agro-based composite also tested out as having free-HCHO values of *13 mg/100 g board.

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“…Formaldehyde exposure was associated with an increased risk for Hodgkin lymphoma multiple myeloma and leukemia, particularly myeloid leukemia, that increased with peak and average intensity of exposure [11]. In an attempt to over-come these, there have been various efforts made to devise a nonaldehydes containing fixatives for general purposes.…”

Section: Introductionmentioning

confidence: 99%

A Comparison Study of Histochemical Staining of Various Tissues after Carnoy’s Versus after Formalin Fixation

Ahmed¹

2011

JCST

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Mortality From Lymphohematopoietic Malignancies Among Workers in Formaldehyde Industries: The National Cancer Institute Cohort

Cited by 200 publications

References 29 publications

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage

Preformed Amide-containing biopolymer for Improving the Environmental Performance of Synthesized Urea–formaldehyde in Agro-fiber Composites

A Comparison Study of Histochemical Staining of Various Tissues after Carnoy’s Versus after Formalin Fixation

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