Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-Country Study of nuclear industry workers

Vrijheid, Martine; Cardis, Elisabeth; Ashmore, Patrick; Auvinen, Anssi; Bae, Jong-Myon; Engels, Hilde; Gilbert, Ethel S.; Gulis, Gabriel; Habib, Rima R.; Howe, Geoffrey R.; Kurtinaitis, Juozas; Malker, Hans; Muirhead, Colin R.; Richardson, David B.; Rodríguez‐Artalejo, Fernando; Rogel, A.; Schubauer‐Berigan, Mary K.; Tardy, Hélène; Telle-Lamberton, M.; Usel, M.; Veress, K.

doi:10.1093/ije/dym138

Cited by 140 publications

(115 citation statements)

References 26 publications

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“…CVD mortality and radiation dose (ERR/Sv = 0.09, 95% CI: -0.43, 0.70) [22]. A statistically significant association, with ERR/Sv of 0.65 (90% CI: 0.36, 0.98), has recently been reported in a large cohort of workers at the British Nuclear Fuels [23].…”

Section: Resultsmentioning

confidence: 98%

Low dose ionizing radiation exposure and cardiovascular disease mortality: cohort study based on Canadian national dose registry of radiation workers

Zielinski¹,

Ashmore²,

Band³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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Objectives: The purpose of our study was to assess the risk of cardiovascular disease (CVD) mortality in a Canadian cohort of 337 397 individuals (169 256 men and 168 141 women) occupationally exposed to ionizing radiation and included in the National Dose Registry (NDR) of Canada. Material and Methods: Exposure to high doses of ionizing radiation, such as those received during radiotherapy, leads to increased risk of cardiovascular diseases. The emerging evidence of excess risk of CVDs after exposure to doses well below those previously considered as safe warrants epidemiological studies of populations exposed to low levels of ionizing radiation. In the present study, the cohort consisted of employees at nuclear power stations (nuclear workers) as well as medical, dental and industrial workers. The mean whole body radiation dose was 8.6 mSv for men and 1.2 mSv for women. Results: During the study period , as many as 3 533 deaths from cardiovascular diseases have been identified (3 018 among men and 515 among women). In the cohort, CVD mortality was significantly lower than in the general population of Canada. The cohort showed a significant dose response both among men and women. Risk estimates of CVD mortality in the NDR cohort, when expressed as excess relative risk per unit dose, were higher than those in most other occupational cohorts and higher than in the studies of Japanese atomic bomb survivors. Conclusions: The study has demonstrated a strong positive association between radiation dose and the risk of CVD mortality. Caution needs to be exercised when interpreting these results, due to the potential bias introduced by dosimetry uncertainties, the possible record linkage errors, and especially by the lack of adjustment for non-radiation risk factors.

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Section: Resultsmentioning

confidence: 98%

Low dose ionizing radiation exposure and cardiovascular disease mortality: cohort study based on Canadian national dose registry of radiation workers

Zielinski¹,

Ashmore²,

Band³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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“…One of the motivations behind this study was the need for radiation risk estimates with greater statistical power than was available in the 15-country study (32). These risk estimates were derived using extended follow-up information from France, UK and U.S. cohorts.…”

Section: Discussionmentioning

confidence: 99%

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

et al. 2015

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“…Of 26 identified studies, only one -concerning US radio logy technologists -provided appreciable evidence of an association between cumulative radiation exposure and CSD (8). Other evidence that low doses of external ionizing radiation are associated with an increased risk of CSD has come from a cohort of international nuclear workers (9) and a recent study of Chernobyl clean-up workers (10). These results have not, however, shown a consistent pattern of increased mortality from CSD.…”

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confidence: 99%

Mortality from circulatory system diseases and low-level radon exposure in the French cohort study of uranium miners, 1946–1999

Nusinovici¹,

Vacquier²,

Leuraud³

et al. 2010

Scand J Work Environ Health

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Mortality from diseases other than cancer following low doses of ionizing radiation: results from the 15-Country Study of nuclear industry workers

Abstract: The most informative low-dose radiation study to date provides little evidence for a relationship between mortality from non-malignant diseases and radiation dose. However, we cannot rule out risks per unit dose of the same order of magnitude as found in studies at higher doses.

Cited by 140 publications

References 26 publications

Low dose ionizing radiation exposure and cardiovascular disease mortality: cohort study based on Canadian national dose registry of radiation workers

Low dose ionizing radiation exposure and cardiovascular disease mortality: cohort study based on Canadian national dose registry of radiation workers

Mortality from Circulatory System Diseases among French Uranium Miners: A Nested Case-Control Study

Mortality from circulatory system diseases and low-level radon exposure in the French cohort study of uranium miners, 1946–1999

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