Mortality From Alzheimer’s Disease, Parkinson’s Disease, and Dementias in France and Italy

Désesquelles, Aline; Demuru, Elena; Salvatore, Michele Antonio; Pappagallo, Marilena; Frova, Luisa; Meslé, France; Egidi, Viviana

doi:10.1177/0898264313514443

Cited by 25 publications

(33 citation statements)

References 45 publications

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“…We compared our findings with previous studies. According to the findings of Desesquelles et al [9], mortality has been increasing in France since 1985, which is consistent with our results. An Italian study also showed evidence of an upward trend in the period 1985-2003, with the steepest increases in the latter years [10].…”

Section: Discussionsupporting

confidence: 94%

Trends of mortality from Alzheimer's disease in the European Union, 1994–2013

Niu

Álvarez‐Álvarez

Guillén-Grima

et al. 2017

Euro J of Neurology

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Section: Discussionsupporting

confidence: 94%

Trends of mortality from Alzheimer's disease in the European Union, 1994–2013

Niu

Álvarez‐Álvarez

Guillén-Grima

et al. 2017

Euro J of Neurology

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“…Désesquelles et al (2010Désesquelles et al ( , 2012) present a thorough discussion of certification and coding errors affecting Italian multicause mortality data and their possible impact on multicause mortality rates and relationships between causes. Additionally, Désesquelles et al (2010Désesquelles et al ( , 2014Désesquelles et al ( , 2015 address specific causes of death, dealing respectively with cancer, Alzheimer's disease, and infectious diseases. In light of existing evidence that Italian MCOD data is of relatively high quality, we have confidence in the reliability of our results.…”

Section: Discussionmentioning

confidence: 99%

“…With the increasing use of automated coding systems to capture information from death certificates, data on both underlying and contributing causes is now widely available, and many studies are exploring the added value of the MCOD approach in analyzing mortality risks. As described in Désesquelles et al (2010), the MCOD approach contributes in multiple ways to mortality analysis: capturing a country's mortality profile (Manton and Stallard 1982;Manton 1986;Manton and Myers 1987;Mackenbach et al 1995;Stallard 2002;Désesquelles and Meslé 2004;Redelings, Sorvillo, and Simon 2006;Redeling, Wise, and Sorvillo 2007;Frova et al 2009); reevaluating the contribution of a specific cause (Wing and Manton 1981;Nizard and Munoz-Pérez 1993;Coste and Jougla 1994;Wise and Sorvillo 2005;Fuhrman et al 2006;Romon et al 2008;Désesquelles et al 2015); and studying the medical circumstances surrounding the deaths of elderly people and relationships between causes of death (Désesquelles et al 2012(Désesquelles et al , 2014. The present paper focuses on this last issue in order to better understand the system of relationships among causes of death for older men and women in Italy.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

“…In so doing, we also address an important limitation in existing studies: the neglect of multiple relationships among causes of death and the crucial role that some of these may play in the death process. There is evidence that relations among causes of death are too complex to be captured by current MCOD indicators (Désesquelles et al 2010(Désesquelles et al , 2012(Désesquelles et al , 2014(Désesquelles et al , 2015. A focus on relationships between underlying and contributing causes may hide important relationships among contributing causes that affect the death process, as well as preventing the identification of diseases and conditions that play an active role in pathological patterns.…”

Section: Introduction and Objectivesmentioning

confidence: 99%

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A network approach to studying cause-of-death interrelations

Egidi¹,

Salvatore²,

Rivellini³

et al. 2018

DemRes

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BACKGROUNDMultiple causes of death describe complex death processes marked by the simultaneous presence of several diseases and conditions, primarily at older ages. OBJECTIVEWe intend to explore the opportunity offered by the Social Network Analysis (SNA) in the study of multiple relationships in the causes of death. METHODSSNA allowed us to reconstruct the complex system of relationships linking the causes of death mentioned in the same death certificate for Italian men and women aged 65 years and over in 2011. The causes can be represented as actors of a network where the relational tie establishes a linkage between a cause mentioned together with another. The strength of this association is represented by the frequency of the joint mentioning in the same certificate controlling for the confounding effect due to the different prevalence of the causes. RESULTSThe analysis clearly brought out that causes of death describe a very dense system of relationships. Considering only the strongest associations, the graphical analysis showed subgroups of causes, within which cross-references are very frequent while mentions external to the group are rare. Moreover, SNA concepts and instruments allowed us to identify causes playing important roles in death processes and mortality patterns.1 Sapienza Università di Roma, Rome, Italy. 2 Istituto Nazionale di Statistica (ISTAT), Rome, Italy. 3 Università Cattolica del Sacro Cuore, Milan, Italy. Email: giulia.rivellini@unicatt.it. Egidi et al.:A network approach to studying cause-of-death interrelations 374http://www.demographic-research.org CONCLUSIONS SNA has proved to be very powerful in identifying the relationships between causes of death, on which health policies should take action to further reduce mortality risks of elderly persons. CONTRIBUTIONThe method was able to highlight complex structures composing subgroups of diseases, offering a clearer picture of the characteristics of death processes than the analyses conducted so far have allowed.

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“…However, the UC approach is often insufficient to properly analyze mortality, as it captures only the “tip of the iceberg.” In fact, it could divert the attention from conditions that tend to be reported as contributory causes. As a consequence, the contribution of these conditions to overall mortality could be underestimated [10–12]. …”

Section: Introductionmentioning

confidence: 99%

Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

Grande

Suligoi

Grippo

et al. 2017

Popul Health Metrics

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BackgroundMultiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS.MethodsWe conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS.ResultsThe most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin’s disease (ASPR = 3.1).ConclusionsStudy findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population.

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Mortality From Alzheimer’s Disease, Parkinson’s Disease, and Dementias in France and Italy

Abstract: Our research highlights several consequences of the conditions under study that could be targeted by public health policy. It also speaks to the existence of differences in diagnosis/certification practices that may explain differences in mortality levels.

Cited by 25 publications

References 45 publications

Trends of mortality from Alzheimer's disease in the European Union, 1994–2013

Trends of mortality from Alzheimer's disease in the European Union, 1994–2013

A network approach to studying cause-of-death interrelations

Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

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